Meta-analysis of exome array data identifies six novel genetic loci for lung function.
| Title: | Meta-analysis of exome array data identifies six novel genetic loci for lung function. |
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| Authors: | VE Jackson; JC Latourelle; LV Wain; AV Smith; ML Grove; TM Bartz; M Obeidat; MA Province; W Gao; B Qaiser; DJ Porteous; PA Cassano; TS Ahluwalia; N Grarup; J Li; E Altmaier; J Marten; SE Harris; A Manichaikul; TD Pottinger; R Li-Gao; A Lind-Thomsen; A Mahajan; L Lahousse; M Imboden; A Teumer; B Prins; L-P Lyytikäinen; G Eiriksdottir; N Franceschini; CM Sitlani; JA Brody; Y Bossé; W Timens; A Kraja; A Loukola; W Tang; Y Liu; J Bork-Jensen; JM Justesen; A Linneberg; LA Lange; R Rawal; S Karrasch; JE Huffman; BH Smith; G Davies; KM Burkart; JC Mychaleckyj; TN Bonten; S Enroth; L Lind; GG Brusselle; A Kumar; B Stubbe; Understanding Society Scientific Group; M Kähönen; AB Wyss; BM Psaty; SR Heckbert; K Hao; T Rantanen; SB Kritchevsky; K Lohman; T Skaaby; C Pisinger; T Hansen; H Schulz; O Polasek; A Campbell; JM Starr; SS Rich; DO Mook-Kanamori; Å Johansson; E Ingelsson; AG Uitterlinden; S Weiss; OT Raitakari; V Gudnason; KE North; SA Gharib; DD Sin; KD Taylor; GT O'Connor; J Kaprio; TB Harris; O Pederson; H Vestergaard; JG Wilson; K Strauch; C Hayward; S Kerr; IJ Deary; RG Barr; R de Mutsert; U Gyllensten; AP Morris; MA Ikram; N Probst-Hensch; S Gläser; E Zeggini; T Lehtimäki; DP Strachan; J Dupuis; AC Morrison; IP Hall; MD Tobin; SJ London |
| Publication Year: | 2018 |
| Collection: | University of Leicester: Figshare |
| Subject Terms: | COPD; GWAS; Lung function; exome array; respiratory |
| Description: | Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV 1), forced vital capacity (FVC) and the ratio of FEV 1 to FVC (FEV 1/FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 individuals of European ancestry from 23 studies, and 7,721 individuals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent individuals. Results: We identified significant (P |
| Document Type: | article in journal/newspaper |
| Language: | unknown |
| Relation: | 2381/45421 |
| Availability: | https://figshare.com/articles/journal_contribution/Meta-analysis_of_exome_array_data_identifies_six_novel_genetic_loci_for_lung_function_/10220870 |
| Rights: | CC BY 4.0 |
| Accession Number: | edsbas.4A387184 |
| Database: | BASE |