| Title: |
Impact of Single Hemodialysis Treatment on immune Cell Subpopulations |
| Authors: |
Chiara Donadei; Andrea Angeletti; Valeria Pizzuti; Fulvia Zappulo; Diletta Conte; Maria Cappuccilli; Anna Laura Chiocchini; Anna Scrivo; Delia Apuzzo; Maria Addolorata Mariggiò; Lorenzo Gasperoni; Gabriele Donati; Gaetano La Manna |
| Source: |
Journal of Clinical Medicine, Vol 12, Iss 9, p 3107 (2023) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2023 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
hemodialysis; immune response; inflammation; lymphocytes; Th1; Th2; Medicine |
| Description: |
Hemodialysis (HD) is known to trigger a chronic inflammatory status, affecting the innate and acquired immune response. This study was aimed at a comparative analysis of immune cell subsets, proliferation, and apoptosis in subjects receiving chronic HD treatment with respect to a healthy control. Regardless of the dialysis filter used, we observed a reshaping of the acquired immune component both with respect to healthy patients and between the various sessions of dialysis treatment, with an impairment of CD3 cells, along with an increase in CD4 and CD8 cell populations producing pro-inflammatory factors such as IL-17 and IFN-gamma. The population of B cells, monocytes and NK cells were not impaired by the dialysis procedure. These results confirmed the high impact of the HD treatment on the patient’s immune system, underlying the imbalance of T cell counterparts. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/2077-0383/12/9/3107; https://doaj.org/toc/2077-0383; https://doaj.org/article/28e9d4566b8d4160831979764551238e |
| DOI: |
10.3390/jcm12093107 |
| Availability: |
https://doi.org/10.3390/jcm12093107; https://doaj.org/article/28e9d4566b8d4160831979764551238e |
| Accession Number: |
edsbas.4A4ACA01 |
| Database: |
BASE |