| Title: |
Australian data on the utilisation and duration on treatment of ibrutinib with a proton pump inhibitor in patients with relapsed or refractory chronic lymphocytic leukaemia |
| Authors: |
Salvaris, Ross; Mulligan, Stephen; Puig, Andrea; McGeachie, Marija; Opat, Stephen |
| Source: |
Internal Medicine Journal ; volume 53, issue 11, page 2115-2118 ; ISSN 1444-0903 1445-5994 |
| Publisher Information: |
Wiley |
| Publication Year: |
2023 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
In Australia, over half of patients with relapsed/refractory chronic lymphocytic leukaemia treated with ibrutinib use concomitant proton pump inhibitors (PPIs). High gastric pH reduces the bioavailability of some Bruton tyrosine kinase inhibitors. There was no difference in duration on ibrutinib with or without concomitant PPI (unadjusted P = 0.61; adjusted hazard ratio: 1.23, 95% confidence interval: 0.75–2.02, P = 0.411). PPI use does not affect ibrutinib treatment persistence. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/imj.16267 |
| Availability: |
https://doi.org/10.1111/imj.16267; https://onlinelibrary.wiley.com/doi/pdf/10.1111/imj.16267 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.4A9798D9 |
| Database: |
BASE |