| Publisher Information: |
Uppsala universitet, Reproduktiv hälsa; Uppsala universitet, Obstetrisk och reproduktiv hälsoforskning; Univ Tubingen, Tubingen Ctr Mental Hlth TuCMH, Dept Psychiat & Psychotherapy, Womens Mental Hlth & Brain Funct, Tubingen, Germany.; Univ Tubingen, Tubingen Ctr Mental Hlth TuCMH, Dept Psychiat & Psychotherapy, Womens Mental Hlth & Brain Funct, Tubingen, Germany.;German Ctr Mental Hlth DZPG, Partner Site Tubingen, Tubingen, Germany.; German Inst Human Nutr, Dept Decis Neurosci & Nutr, Nuthetal, Germany.;Charite Univ Med Berlin, Berlin, Germany.;Free Univ Berlin, Humboldt Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Neurosci Res Ctr, Berlin, Germany.;German Ctr Diabet Res, Munchen Neuherberg, Germany.; Univ Innsbruck, Dept Psychol, Innsbruck, Austria.; Univ Tubingen, Tubingen Ctr Mental Hlth TuCMH, Dept Psychiat & Psychotherapy, Womens Mental Hlth & Brain Funct, Tubingen, Germany.;German Ctr Mental Hlth DZPG, Partner Site Tubingen, Tubingen, Germany.;Univ Tubingen, LEAD Grad Sch & Res Network, Tubingen, Germany. |
| Description: |
Pregnancy is a psycho-neuro-endocrinological transition phase presenting a window of vulnerability for mental health. Emotion regulation, a transdiagnostic factor for psychopathology, is influenced by estradiol across the menstrual cycle on the behavioral and neural level. Whether this is also the case in the antepartum period remains unknown. For the first time, behavioral and neural emotion regulation were investigated in healthy pregnant females with extremely high estradiol levels during the second trimester (N = 15) using a functional magnetic resonance imaging (fMRI) paradigm. Results were compared with naturally cycling females with high (N = 16) and low estradiol levels (N = 16). Although pregnant females reported the lowest trait use of cognitive reappraisal, all participants successfully regulated their emotions by applying cognitive reappraisal in the scanner. During downregulation of negative emotions, all females had increased activity in the left middle frontal gyrus. Pregnant females showed no significant differences in functional connectivity (psychophysiological interaction, resting-state) related to emotion regulation compared with the nonpregnant groups. However, group differences emerged for amygdala activation. In pregnant females, increased amygdala activity predicted reduced regulation success and was positively associated with depression scores. This first fMRI study during pregnancy indicates that depression scores are reflected in heightened amygdala activity already observable in the antepartum period. Thus, through its association with reduced regulation success, increased amygdala activity suggests a neural risk marker for peripartum mental health. The findings highlight the importance of investigating neural and behavioral emotion regulation in the ante- and postpartum period, eventually allowing enhanced identification, prevention, and treatment of peripartum mental ill-health. |