| Title: |
[ 11 C]Ascorbic and [ 11 C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography |
| Authors: |
Carroll, VN; Truillet, C; Shen, B; Flavell, RR; Shao, X; Evans, MJ; VanBrocklin, HF; Scott, PJH; Chin, FT; Wilson, DM |
| Source: |
Chemical Communications, vol 52, iss 27 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2016 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
34 Chemical Sciences (for-2020); Dietary Supplements (rcdc); Biomedical Imaging (rcdc); Ascorbic Acid (mesh); Carbon Radioisotopes (mesh); Oxidation-Reduction (mesh); Positron-Emission Tomography (mesh); Reactive Oxygen Species (mesh); 03 Chemical Sciences (for); Organic Chemistry (science-metrix); 40 Engineering (for-2020) |
| Time: |
4888 - 4890 |
| Description: |
Here we report the radiosynthesis of an endogenous redox pair, [(11)C]ascorbic acid ([(11)C]VitC) and [(11)C]dehydroascorbic acid ([(11)C]DHA), the reduced and oxidized forms of vitamin C, and their application to ROS sensing. These results provide the basis for in vivo detection of ROS using positron emission tomography (PET). |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt85s3h1gx; https://escholarship.org/uc/item/85s3h1gx; https://escholarship.org/content/qt85s3h1gx/qt85s3h1gx.pdf |
| DOI: |
10.1039/c6cc00895j |
| Availability: |
https://escholarship.org/uc/item/85s3h1gx; https://escholarship.org/content/qt85s3h1gx/qt85s3h1gx.pdf; https://doi.org/10.1039/c6cc00895j |
| Rights: |
public |
| Accession Number: |
edsbas.4AEB4DC2 |
| Database: |
BASE |