| Title: |
In Vivo Antimalarial Evaluation of Crude Extract, Solvent Fractions, and TLC-Isolated Compounds from Olea europaea Linn subsp. cuspidata (Oleaceae) |
| Authors: |
Gebretekle Gebremichael Hailesilase; Yarra Rajeshwar; Gebremedhin Solomon Hailu; Gereziher Gebremedhin Sibhat; Helen Bitew |
| Source: |
Evidence-Based Complementary and Alternative Medicine, Vol 2020 (2020) |
| Publisher Information: |
Hindawi Limited |
| Publication Year: |
2020 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Other systems of medicine; RZ201-999 |
| Description: |
Malaria is a major global public health problem caused by Plasmodium parasites. Drug resistance is becoming a great challenge. New drugs with novel mechanism of action are urgently required. In malarious countries, medicinal plants are commonly used for malaria treatment. Olea europaea is traditionally used against malaria in Ethiopia. The aim of this study was to isolate and evaluate antimalarial activity of chemical constituents extracted from Olea europaea against chloroquine-sensitive Plasmodium berghei-infected mice. Stem bark of Olea europaea was extracted with 80% methanol and fractionated with three solvents. The butanol fraction was subjected to isolation with preparative thin-layer chromatography (PTLC). Acute oral toxicity studies were conducted in mice as per the Organization for Economic Co-operation and Development (OECD) guideline 425. Antimalarial activities of the test substances were evaluated using Peter’s 4-day suppressive test. The crude extract showed significant (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
http://dx.doi.org/10.1155/2020/6731485; https://doaj.org/toc/1741-427X; https://doaj.org/toc/1741-4288; https://doaj.org/article/d334595e4c5a4236882511c5b9c7f45b |
| DOI: |
10.1155/2020/6731485 |
| Availability: |
https://doi.org/10.1155/2020/6731485; https://doaj.org/article/d334595e4c5a4236882511c5b9c7f45b |
| Accession Number: |
edsbas.4AF7E176 |
| Database: |
BASE |