| Title: |
Association of Mrna Vaccination With Clinical and Virologic Features of COVID-19 Among Us Essential and Frontline Workers |
| Authors: |
The HEROES-RECOVER Network; Thompson, Mark G; Yoon, Sarang K; Naleway, Allison L; Meece, Jennifer; Fabrizio, Thomas P; Caban-Martinez, Alberto J; Burgess, Jefferey L; Gaglani, Manjusha; Olsho, Lauren E W; Bateman, Allen; Lundgren, Jessica; Grant, Lauren; Phillips, Andrew L; Groom, Holly C; Stefanski, Elisha; Solle, Natasha Schaefer; Ellingson, Katherine; Lutrick, Karen; Dunnigan, Kayan; Wesley, Meredith G; Guenther, Kyley; Hunt, Angela; Mak, Josephine; Hegmann, Kurt T; Kuntz, Jennifer L; Bissonnette, Adam; Hollister, James; Rose, Spencer; Morrill, Tyler C; Respet, Karley; Fowlkes, Ashley L; Thiese, Matthew S; Rivers, Patrick; Herring, Meghan K; Odean, Marilyn J; Yoo, Young M; Brunner, Matthew; Bedrick, Edward J; Fleary, Deanna E; Jones, John T; Praggastis, Jenna; Romine, James; Dickerson, Monica; Khan, Sana M; Lamberte, Julie Mayo; Beitel, Shawn; Webby, Richard J; Tyner, Harmony L |
| Source: |
Faculty, Staff and Student Publications |
| Publisher Information: |
DigitalCommons@TMC |
| Publication Year: |
2022 |
| Collection: |
Houston Academy of Medicine-Texas Medical Center (HAM-TMC): DigitalCommons@The Texas Medical Center |
| Subject Terms: |
Adult; Female; Humans; Male; COVID-19; COVID-19 Vaccines; Prospective Studies; RNA; Viral; RNA-Directed DNA Polymerase; SARS-CoV-2; Vaccination; United States; Viral Load; Whole Genome Sequencing; Asymptomatic Infections; Time Factors; Patient Acceptance of Health Care; mRNA Vaccines; Epidemiology; Internal Medicine; Medical Specialties; Medicine and Health Sciences; Public Health |
| Description: |
IMPORTANCE: Data on the epidemiology of mild to moderately severe COVID-19 are needed to inform public health guidance. OBJECTIVE: To evaluate associations between 2 or 3 doses of mRNA COVID-19 vaccine and attenuation of symptoms and viral RNA load across SARS-CoV-2 viral lineages. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study of essential and frontline workers in Arizona, Florida, Minnesota, Oregon, Texas, and Utah with COVID-19 infection confirmed by reverse transcriptase-polymerase chain reaction testing and lineage classified by whole genome sequencing of specimens self-collected weekly and at COVID-19 illness symptom onset. This analysis was conducted among 1199 participants with SARS-CoV-2 from December 14, 2020, to April 19, 2022, with follow-up until May 9, 2022, reported. EXPOSURES: SARS-CoV-2 lineage (origin strain, Delta variant, Omicron variant) and COVID-19 vaccination status. MAIN OUTCOMES AND MEASURES: Clinical outcomes included presence of symptoms, specific symptoms (including fever or chills), illness duration, and medical care seeking. Virologic outcomes included viral load by quantitative reverse transcriptase-polymerase chain reaction testing along with viral viability. RESULTS: Among 1199 participants with COVID-19 infection (714 [59.5%] women; median age, 41 years), 14.0% were infected with the origin strain, 24.0% with the Delta variant, and 62.0% with the Omicron variant. Participants vaccinated with the second vaccine dose 14 to 149 days before Delta infection were significantly less likely to be symptomatic compared with unvaccinated participants (21/27 [77.8%] vs 74/77 [96.1%]; OR, 0.13 [95% CI, 0-0.6]) and, when symptomatic, those vaccinated with the third dose 7 to 149 days before infection were significantly less likely to report fever or chills (5/13 [38.5%] vs 62/73 [84.9%]; OR, 0.07 [95% CI, 0.0-0.3]) and reported significantly fewer days of symptoms (10.2 vs 16.4; difference, -6.1 [95% CI, -11.8 to -0.4] days). Among those with Omicron infection, the risk of ... |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://digitalcommons.library.tmc.edu/uthmed_docs/2589; https://digitalcommons.library.tmc.edu/context/uthmed_docs/article/3541/viewcontent/Association_of_mRNA_Vaccination_With_Clinical_and_Virologic_Features_of_COVID_19_Among_US_Essential_and_Frontline_Workers___PMC.pdf |
| DOI: |
10.1001/jama.2022.18550 |
| Availability: |
https://digitalcommons.library.tmc.edu/uthmed_docs/2589; https://doi.org/10.1001/jama.2022.18550; https://digitalcommons.library.tmc.edu/context/uthmed_docs/article/3541/viewcontent/Association_of_mRNA_Vaccination_With_Clinical_and_Virologic_Features_of_COVID_19_Among_US_Essential_and_Frontline_Workers___PMC.pdf |
| Accession Number: |
edsbas.4AFFCD24 |
| Database: |
BASE |