| Title: |
Amount and intensity of daily total physical activity, step count and risk of incident cancer in the UK Biobank |
| Authors: |
Shreves, AH; Small, SR; Walmsley, R; Chan, S; Saint-Maurice, PF; Moore, SC; Papier, K; Gaitskell, K; Travis, RC; Matthews, CE; Doherty, A |
| Publisher Information: |
BMJ Publishing Group |
| Publication Year: |
2025 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Objectives: To investigate associations between daily physical activity, activity intensity and step counts with incident cancer risk. Methods: Prospective analysis of UK Biobank participants who wore wrist-based accelerometers for 7 days, followed for cancer incidence (mean follow-up 5.8 years, SD 1.3). Time-series machine-learning models derived total physical activity, sedentary behaviour (SB), light-intensity physical activity (LIPA), moderate-vigorous-intensity physical activity (MVPA) and step counts. The outcome was a composite of 13 cancers previously associated with low physical activity in questionnaire-based studies. Cox proportional hazard models estimated HRs and 95% CIs, adjusted for demographic, health and lifestyle factors. We also explored associations of LIPA, MVPA and SB with cancer risk. Results: Among 85 394 participants (median age 63 (IQR 56–68)), 2633 were diagnosed with cancer during follow-up. Compared with individuals in the lowest quintile of total physical activity ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1136/bjsports-2024-109360 |
| Availability: |
https://doi.org/10.1136/bjsports-2024-109360; https://ora.ox.ac.uk/objects/uuid:38586d3e-7091-4f10-917b-4637566cd885 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.4B00AEC6 |
| Database: |
BASE |