| Title: |
Knowledge Discovery in Databases of Proteomics by Systems Modeling in Translational Research on Pancreatic Cancer |
| Authors: |
Resell, Mathilde; Graarud, Elisabeth Pimpisa; Rabben, Hanne-Line; Sharma, Animesh; Hagen, Lars; Hoang, Linh; Skogaker, Nan T; Aarvik, Anne; Svensson, Magnus K; Amrutkar, Manoj; Verbeke, Caroline S; Batra, Surinder K.; Qvigstad, Gunnar; Wang, Timothy C; Rustgi, Anil; Chen, Duan; Zhao, Chun-Mei |
| Source: |
Journal Articles: Biochemistry & Molecular Biology |
| Publisher Information: |
DigitalCommons@UNMC |
| Publication Year: |
2025 |
| Collection: |
University of Nebraska Medical Center Research: DigitalCommons@UNMC |
| Subject Terms: |
bioinformatics; networks; proteomics; research models; signaling pathways; Medical Biochemistry; Medical Molecular Biology |
| Description: |
BACKGROUND: Knowledge discovery in databases (KDD) can contribute to translational research, also known as translational medicine, by bridging the gap between METHODS: This framework includes the data collection of a composition model (various research models), processing model (proteomics) and analytical model (bioinformatics, artificial intelligence/machine leaning and pattern evaluation), knowledge presentation, and feedback loops for hypothesis generation and validation. We applied this workflow to study pancreatic ductal adenocarcinoma (PDAC). RESULTS: We identified the common proteins between human PDAC and various research models CONCLUSIONS: This systems modeling workflow can be a valuable method for KDD, facilitating knowledge discovery in translational targets in general, and in particular to PADA in this case. |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://digitalcommons.unmc.edu/com_bio_articles/176; https://digitalcommons.unmc.edu/context/com_bio_articles/article/1176/viewcontent/Knowledge_Discovery_in_Databases_of_Proteomics_by_Systems.pdf; https://digitalcommons.unmc.edu/context/com_bio_articles/article/1176/filename/0/type/additional/viewcontent/Knowledge_Discovery_in_Databases_of_Proteomics_by_Systems_Supplement.pdf |
| DOI: |
10.3390/proteomes13020020 |
| Availability: |
https://digitalcommons.unmc.edu/com_bio_articles/176; https://doi.org/10.3390/proteomes13020020; https://digitalcommons.unmc.edu/context/com_bio_articles/article/1176/viewcontent/Knowledge_Discovery_in_Databases_of_Proteomics_by_Systems.pdf; https://digitalcommons.unmc.edu/context/com_bio_articles/article/1176/filename/0/type/additional/viewcontent/Knowledge_Discovery_in_Databases_of_Proteomics_by_Systems_Supplement.pdf |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.4B0C7E76 |
| Database: |
BASE |