| Title: |
Mechanical characterization of femoral popliteal artery: experiments, histology, and model comparison |
| Authors: |
Cai, Renye; Liu, Aoling; Hu, Qingkun; Lu, Jie; Zhang, Heng; Kong, Chunyu; Zhu, Yiwei; Gu, Xiaolong; Lai, Xuwen; Feng, Zhi-Qiang; Peyraut, François |
| Contributors: |
School of Automobile and Transportation Engineering; Guangdong Polytechnic Normal University; Department of Cardiovascular Surgery; PLA General Hospital of Southern Theater Command; Department of Cardiovascular Medicine; Department of Pathology; Laboratoire de Mécanique et d'Energétique d'Evry (LMEE); Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay; School of Mechanics and Aerospace Engineering; Southwest Jiaotong University (SWJTU); Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB); Université de Technologie de Belfort-Montbeliard (UTBM)-Centre National de la Recherche Scientifique (CNRS)-Université Bourgogne Europe (UBE) |
| Source: |
ISSN: 0261-3069. |
| Publisher Information: |
CCSD; Elsevier |
| Publication Year: |
2025 |
| Subject Terms: |
Femoral popliteal artery; Nonlinear Constitutive model; Mechanical properties; Biaxial testing; [SPI]Engineering Sciences [physics] |
| Description: |
International audience ; Peripheral artery disease (PAD) has a high mortality rate and can bring various cardiovascular disease risks, making it an extremely serious type of disease. The porcine femoral popliteal artery (FPA) was selected as research objects to obtain detailed mechanical behavior and arterial structure information of lower limb arteries through biaxial tensile experiments and histopathological analysis. The results showed that the FPA exhibits higher compliance in the longitudinal direction than in the circumferential direction and greater stiffness in the circumferential direction. Histopathological analysis revealed the microstructural changes in the arterial samples after stretching, including partial rupture of elastic fibers, rearrangement and distribution of collagen fibers, and morphological changes in smooth muscle cells (SMCs). The experiment found that tissue damage begins to accumulate when FPA strain exceeds 30%. Both the polyconvex quadratic polynomial SEF (Strain Energy Function) and the exponential SEF effectively captured the mechanical response of these arteries. This study advances the understanding of the mechanical properties and injury mechanisms of the FPA, evaluates the applicability of SEFs, and provides a foundation for future computer modeling research. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1016/j.matdes.2025.114472 |
| Availability: |
https://hal.science/hal-05317848; https://hal.science/hal-05317848v1/document; https://hal.science/hal-05317848v1/file/Cai2025.pdf; https://doi.org/10.1016/j.matdes.2025.114472 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.4B9EEEC1 |
| Database: |
BASE |