| Title: |
Association of Nucleus Basalis of Meynert Functional Connectivity and Cognition in Idiopathic Rapid-Eye-Movement Sleep Behavior Disorder |
| Authors: |
Byun, JI; Cha, KS; Kim, M; Lee, WJ; Lee, HS; Sunwoo, JS; Shin, JW; Kim, TJ; Jun, JS; Kim, HJ; Shin, WC; Schenck, CH; Lee, SK; Jung, KY |
| Contributors: |
112418; Kim, TJ |
| Publication Year: |
2022 |
| Subject Terms: |
cognitive function; functional brain imaging; mild cognitive impairment; nucleus basalis of Meynert; REM sleep behavior disorder |
| Description: |
BACKGROUND AND PURPOSE: Cognitive impairments are common in isolated rapid-eye-movement sleep behavior disorder (iRBD), in which the cholinergic system may play an important role. This study aimed to characterize the cortical cholinergic activity using resting-state functional connectivity (FC) of the nucleus basalis of Meynert (NBM) according to the cognitive status of iRBD patients. METHODS: In this cross-sectional study, 33 patients with polysomnography-confirmed iRBD and 20 controls underwent neuropsychological evaluations and resting-state functional magnetic resonance imaging. Thirteen of the iRBD patients had mild cognitive impairment (iRBD-MCI), and the others were age-matched patients with normal cognition (iRBD-NC). The seed-to-voxel NBM-cortical FC was compared among the patients with iRBD-MCI, patients with iRBD-NC, and controls. Correlations between average values of significant clusters and cognitive function scores were calculated in the patients with iRBD. RESULTS: There were group differences in the FC of the NBM with the left lateral occipital cortex and lingual gyrus (adjusted for age, sex, and education level). The strength of FC was lower in the iRBD-MCI group than in the iRBD-NC and control groups (each post-hoc p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
36062774 |
| Relation: |
J017386586; http://repository.ajou.ac.kr/handle/201003/24778; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444555 |
| DOI: |
10.3988/jcn.2022.18.5.562 |
| Availability: |
http://repository.ajou.ac.kr/handle/201003/24778; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444555; https://doi.org/10.3988/jcn.2022.18.5.562 |
| Accession Number: |
edsbas.4BBF1D3 |
| Database: |
BASE |