| Title: |
Autophagy and mitophagy in dermatological disease: a comprehensive review from molecular pathways to therapeutic frontiers |
| Authors: |
D'Ambrosio, Luca; Greco, Maria Elisabetta; Forte, Maurizio; Vecchio, Daniele; Schiavon, Sonia; Nonno, Flavio Di; Tahir, Shazia; Picchio, Vittorio; Cozzolino, Claudia; Sarto, Gianmarco; Bernardi, Marco; Spadafora, Luigi; Simeone, Beatrice; Vinciguerra, Mattia; Sciarretta, Sebastiano; Frati, Giacomo; Greco, Ernesto; Potenza, Concetta; Proietti, Ilaria; Morroni, Jacopo; Dietrich, Elisa; Schirone, Leonardo |
| Contributors: |
D'Ambrosio, Luca; Greco, Maria Elisabetta; Forte, Maurizio; Vecchio, Daniele; Schiavon, Sonia; Nonno, Flavio Di; Tahir, Shazia; Picchio, Vittorio; Cozzolino, Claudia; Sarto, Gianmarco; Bernardi, Marco; Spadafora, Luigi; Simeone, Beatrice; Vinciguerra, Mattia; Sciarretta, Sebastiano; Frati, Giacomo; Greco, Ernesto; Potenza, Concetta; Proietti, Ilaria; Morroni, Jacopo; Dietrich, Elisa; Schirone, Leonardo |
| Publication Year: |
2026 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
autophagy; dermatological disease; immunodermatology; mitophagy; skin disorder; skin homeostasis |
| Description: |
Autophagy - the cell's built-in recycling and quality-control programme - touches every layer of cutaneous biology. In keratinocytes it sculpts the cornified envelope; in melanocytes it balances pigment synthesis and oxidative stress; in immune and appendageal cells it fine-tunes defence, repair and hair-follicle cycling. When this choreography falters, skin disorders emerge. This review journeys from basic mechanisms (ULK1 signalling, Beclin-1/VPS34 nucleation, LC3B lipidation, selective mitophagy) to their fingerprints in health and disease. We dissect how autophagy malfunctions drive psoriasis hyper-proliferation, atopic-dermatitis barrier leakiness, vitiligo depigmentation and the metabolic rewiring of melanoma. Non-melanoma cancers, infectious dermatoses, wound repair, ageing and photo-damage are mapped onto the same autophagic atlas. Therapeutically, the pathway is a double-edged sword. mTOR or caloric-restriction mimetics jump-start a protective flux; chloroquine derivatives and ULK1 blockers clip tumour survival circuits; cannabinoids, photodynamic therapy and immune-checkpoint combinations exploit context-specific toggling between induction and brake. Emerging biomarkers (LC3B-II, p62, AMBRA1) promise patient-stratified interventions. By weaving together molecular detail, pre-clinical insight and clinical translation, we show why autophagy is no longer a backstage process but a star player in dermatology - and how targeting its switches could reshape future treatment algorithms. |
| Document Type: |
article in journal/newspaper |
| Language: |
English; Italian |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41353197; volume:21; issue:4; firstpage:1; lastpage:24; numberofpages:24; journal:BIOLOGY DIRECT; https://hdl.handle.net/11573/1757813 |
| DOI: |
10.1186/s13062-025-00703-1 |
| Availability: |
https://hdl.handle.net/11573/1757813; https://doi.org/10.1186/s13062-025-00703-1 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.4BF7512 |
| Database: |
BASE |