| Title: |
Interest of Treating Iron Deficiency, Diagnosed According to Hepcidin Quantification, on Outcomes After a Prolonged Icu Stay Compared to Standard Care: A Multicenter, Randomized, Single-blinded Trial |
| Authors: |
Lasocki, Sigismond; Asfar, Pierre; Jaber, Samir; Ferrandiere, Martine; Kerforne, Thomas; Asehnoune, Karim; Montravers, Philippe; Seguin, Philippe; Peoc’h, Katell; Gergaud, Soizic; Nagot, Nicolas; Lefebvre, Thibaud; Lehmann, Sylvain |
| Contributors: |
Centre Hospitalier Universitaire d'Angers (CHU Angers); Université d'Angers (UA); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Université de Montpellier (UM); Centre Hospitalier Régional Universitaire de Tours (CHRU Tours); Université de Tours (UT); Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ); Université de Poitiers = University of Poitiers (UP); Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); Nantes Université (Nantes Univ); AP-HP - Hôpital Bichat - Claude Bernard Paris; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Université Paris Diderot - Paris 7 (UPD7); Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; Université de Rennes (UR); Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); Hôpital Louis Mourier - AP-HP Colombes; Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge (Labex Gr-Ex); Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); CHU Montpellier = Montpellier University Hospital; Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM); Hepcidane study group: Sigismond Lasocki, Pierre Asfar, Samir Jaber, Martine Ferrandiere, Thomas Kerforne, Karim Asehnoune, Philippe Montravers, Philippe Seguin, Katell Peoc'h, Soizic Gergaud, Nicolas Nagot, Thibaud Lefebvre, Sylvain Lehmann, François Beloncle, Alain Mercat, Thomas Gaillard, Maxime Leger, Emmanuel Rineau, Cyril Sargentini, Claire Geneve, Herve Puy, Grégoire Mercier, Gregory Marin, Constance Delaby, Christophe Hirtz, Gerald Chanques, Antoine Roquilly, Matthieu Boisson, Claire Dahyot-Fizelier, Olivier Mimoz, Sonia Isslame, Yoann Launey, Mathilde Barbaz |
| Source: |
https://hal.science/hal-02941084 ; 2022. |
| Publisher Information: |
CCSD |
| Publication Year: |
2022 |
| Collection: |
Université François-Rabelais de Tours: HAL |
| Subject Terms: |
Anemia; Critically ill; Erythropoietin; Hepcidin; Iron (treatment); Iron deficiency; Length of stay; Mortality; [SDV]Life Sciences [q-bio] |
| Description: |
Background : Anemia is a significant problem in patients on ICU. Its commonest cause, iron deficiency (ID), is difficult to diagnosed in the context of inflammation. Hepcidin is a new marker of ID. We aimed to assess whether hepcidin levels would accurately guide treatment of ID in critically ill anemic patients after a prolonged ICU stay and affect the post-ICU outcomes. Methods : In a controlled, single-blinded, multicenter study, anemic (WHO definition) critically ill patients with an ICU stay ≥5 days were randomized when discharge was expected to either intervention by hepcidin treatment protocol or control. In the intervention arm patients were treated with intravenous iron (1g of ferric carboxymaltose) when hepcidin was |
| Document Type: |
report |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33588893; PUBMED: 33588893; PUBMEDCENTRAL: PMC7885380 |
| DOI: |
10.21203/rs.3.rs-73447/v1 |
| Availability: |
https://hal.science/hal-02941084; https://hal.science/hal-02941084v1/document; https://hal.science/hal-02941084v1/file/Sigismond%20%20Lasocki%20%20et%20al.,.pdf; https://doi.org/10.21203/rs.3.rs-73447/v1 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.4C0E3EC0 |
| Database: |
BASE |