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Differential gene regulation by nutrient restriction and hypoxia in cultured human placental extravillous trophoblasts (HTR‐8/SVneo)

Title: Differential gene regulation by nutrient restriction and hypoxia in cultured human placental extravillous trophoblasts (HTR‐8/SVneo)
Authors: Jones, Sara; Brannon, Patsy M
Contributors: Cornell University
Source: The FASEB Journal ; volume 27, issue S1 ; ISSN 0892-6638 1530-6860
Publisher Information: Wiley
Publication Year: 2013
Collection: Wiley Online Library (Open Access Articles via Crossref)
Description: Both maternal undernutrition and hypoxia impair placental and fetal growth, but the mechanisms are unknown. We cultured trophoblasts in nutrient‐replete media (C; 20% O 2 ), hypoxia (Hx; 1% O 2 in nutrient‐replete media), 75% nutrient‐restricted media (NR; 20% O 2 ), or NR‐Hx. Hx or NR alone reduced growth 40–45% and together by 70% (p
Document Type: article in journal/newspaper
Language: English
DOI: 10.1096/fasebj.27.1_supplement.640.20
Availability: https://doi.org/10.1096/fasebj.27.1_supplement.640.20
Rights: http://onlinelibrary.wiley.com/termsAndConditions#vor
Accession Number: edsbas.4C471637
Database: BASE