| Title: |
Clinical Outcome of Patients with Raised Intraepithelial Lymphocytes with Normal Villous Architecture on Duodenal Biopsy |
| Authors: |
Parihar, Vikrant; Stack, Roisin; Alakkari, Alaa; Breslin, Nial; Ryan, B.M.; Crowther, Stephen; McNamara, Deidre |
| Source: |
Digestion ; volume 95, issue 4, page 288-292 ; ISSN 0012-2823 1421-9867 |
| Publisher Information: |
S. Karger AG |
| Publication Year: |
2017 |
| Description: |
Introduction: The finding of a raised intraepithelial lymphocytes (IELs) count with normal villous architecture is of sufficient clinical importance to be reported in routine duodenal biopsies. Aim: To study the clinical and demographic data of patients with isolated increased IELs on duodenal biopsy. Methods: A single-tertiary-centre retrospective study was carried out with a review of medical records of patients with increased IELs. Patients from 2012 to 2014, >18 years with at least one biopsy from the second part of the duodenum with increased IELs; defined as >25 IELs/100 enterocytes, with preserved villous architecture were identified from our histopathology database with exclusion of patients with coeliac disease (CD).Clinical and demographic data were recorded following a chart review. CD was diagnosed by the attending physician based on the Physician Global Assessment. Data was compared between groups using a Student t test and ORs were calculated as appropriate. Statistical significance was set a priori at p < 0.05. Results: Over 24 months, 6,244 patients were found to have duodenal biopsies and 114 (1.8%) had isolated increased IELs. Of the patients with increased IELs, the mean age was 50 years and 34 (30%) were male. Follow-up was available in 75 (65%) of these and CD was subsequently diagnosed in 32% (n = 24). CD was associated with the female gender (22 out of 24 vs. 39 out of 51, OR 7.5, older age 55 vs. 41 years, p < 0.04), and higher IEL count with an IEL of >40 in 11 out of 24 (46%) with CD vs. 12 out of 51 (24%) without CD, p = 0.0006. Conclusion: It is a non-specific but important finding, as it can have clinical implications. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1159/000476061 |
| Availability: |
https://doi.org/10.1159/000476061; https://www.karger.com/Article/Pdf/476061 |
| Rights: |
https://www.karger.com/Services/SiteLicenses ; https://www.karger.com/Services/SiteLicenses |
| Accession Number: |
edsbas.4C882FA7 |
| Database: |
BASE |