Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.
| Title: | Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. |
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| Authors: | Goodson WH 3rd; Lowe L; Carpenter DO; Gilbertson M; Manaf Ali A; Lopez de Cerain Salsamendi A; Lasfar A; Carnero A; Azqueta A; Amedei A; Charles AK; Collins AR; Ward A; Salzberg AC; Colacci A; Olsen AK; Berg A; Barclay BJ; Zhou BP; Blanco Aparicio C; Baglole CJ; Dong C; Mondello C; Hsu CW; Naus CC; Yedjou C; Curran CS; Laird DW; Koch DC; Carlin DJ; Felsher DW; Roy D; Brown DG; Ratovitski E; Ryan EP; Corsini E; Rojas E; Moon EY; Laconi E; Marongiu F; Al Mulla F; Chiaradonna F; Darroudi F; Martin FL; Van Schooten FJ; Goldberg GS; Wagemaker G; Nangami GN; Calaf GM; Williams G; Wolf GT; Koppen G; Brunborg G; Lyerly HK; Krishnan H; Ab Hamid H; Yasaei H; Sone H; Kondoh H; Salem HK; Hsu HY; Park HH; Koturbash I; Miousse IR; Scovassi AI; Klaunig JE; Vondráček J; Raju J; Roman J; Wise JP Sr; Whitfield JR; Woodrick J; Christopher JA; Ochieng J; Martinez Leal JF; Weisz J; Kravchenko J; Sun J; Prudhomme KR; Narayanan KB; Cohen Solal KA; Moorwood K; Gonzalez L; Soucek L; Jian L; D'Abronzo LS; Lin LT; Li L; Gulliver L; McCawley LJ; Memeo L; Vermeulen L; Leyns L; Zhang L; Valverde M; Khatami M; Romano MF; Chapellier M; Williams MA; Wade M; Manjili MH; Lleonart ME; Xia M; Gonzalez MJ; Karamouzis MV; Kirsch Volders M; Vaccari M; Kuemmerle NB; Singh N; Cruickshanks N; Kleinstreuer N; van Larebeke N; Ahmed N; Ogunkua O; Krishnakumar PK; Vadgama P; Marignani PA; Ghosh PM; Ostrosky Wegman P; Thompson PA; Dent P; Heneberg P; Darbre P; Sing Leung P; Nangia Makker P; Cheng QS; Robey RB; Al Temaimi R; Roy R; Andrade Vieira R; Sinha RK; Mehta R; Vento R; Di Fiore R; Ponce Cusi R; Dornetshuber Fleiss R; Nahta R; Castellino RC; Palorini R; Abd Hamid R; Langie SA; Eltom SE; Brooks SA; Ryeom S; Wise SS; Bay SN; Harris SA; Papagerakis S; Romano S; Eriksson S; Forte S; Casey SC; Luanpitpong S; Lee TJ; Otsuki T; Chen T; Massfelder T; Sanderson T; Guarnieri T; Hultman T; Dormoy V; Odero Marah V; Sabbisetti V; Maguer Satta V; Rathmell WK; Engström W; Decker WK; Bisson WH; Rojanasakul Y; Luqmani Y; Chen Z; Hu Z.; PAVANELLO, SOFIA |
| Contributors: | Goodson WH, 3rd; Lowe, L; Carpenter, Do; Gilbertson, M; Manaf Ali, A; Lopez de Cerain Salsamendi, A; Lasfar, A; Carnero, A; Azqueta, A; Amedei, A; Charles, Ak; Collins, Ar; Ward, A; Salzberg, Ac; Colacci, A; Olsen, Ak; Berg, A; Barclay, Bj; Zhou, Bp; Blanco Aparicio, C; Baglole, Cj; Dong, C; Mondello, C; Hsu, Cw; Naus, Cc; Yedjou, C; Curran, C; Laird, Dw; Koch, Dc; Carlin, Dj; Felsher, Dw; Roy, D; Brown, Dg; Ratovitski, E; Ryan, Ep; Corsini, E; Rojas, E; Moon, Ey; Laconi, E; Marongiu, F; Al Mulla, F; Chiaradonna, F; Darroudi, F; Martin, Fl; Van Schooten, Fj; Goldberg, G; Wagemaker, G; Nangami, Gn; Calaf, Gm; Williams, G; Wolf, Gt; Koppen, G; Brunborg, G; Lyerly, Hk; Krishnan, H; Ab Hamid, H; Yasaei, H; Sone, H; Kondoh, H; Salem, Hk; Hsu, Hy; Park, Hh; Koturbash, I; Miousse, Ir; Scovassi, Ai; Klaunig, Je; Vondráček, J; Raju, J; Roman, J; Wise JP, Sr; Whitfield, Jr; Woodrick, J; Christopher, Ja; Ochieng, J; Martinez Leal, Jf; Weisz, J; Kravchenko, J; Sun, J; Prudhomme, Kr; Narayanan, Kb; Cohen Solal, Ka; Moorwood, K; Gonzalez, L; Soucek, L; Jian, L; D'Abronzo, L; Lin, Lt; L, Li; Gulliver, L; Mccawley, Lj; Memeo, L; Vermeulen, L; Leyns, L; Zhang, L; Valverde, M; Khatami, M; Romano, Mf; Chapellier, M; Williams, Ma; Wade, M |
| Publisher Information: | Oxford University Press |
| Publication Year: | 2015 |
| Collection: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Description: | Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/ mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effect. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/26106142; info:eu-repo/semantics/altIdentifier/wos/WOS:000357048100013; volume:36; firstpage:S254; lastpage:S296; journal:CARCINOGENESIS; https://hdl.handle.net/11577/3203631 |
| DOI: | 10.1093/carcin/bgv039 |
| Availability: | https://hdl.handle.net/11577/3203631; https://doi.org/10.1093/carcin/bgv039 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: | edsbas.4C9A8BD |
| Database: | BASE |