| Title: |
Adaptations in muscle oxidative capacity, fiber size, and oxygen supply capacity after repeated-sprint training in hypoxia combined with chronic hypoxic exposure |
| Authors: |
van der Zwaard, S.; Brocherie, F.; Kom, B. L.G.; Millet, G. P.; Deldicque, L.; van der Laarse, W. J.; Girard, O.; Jaspers, R. T. |
| Source: |
van der Zwaard, S, Brocherie, F, Kom, B L G, Millet, G P, Deldicque, L, van der Laarse, W J, Girard, O & Jaspers, R T 2018, 'Adaptations in muscle oxidative capacity, fiber size, and oxygen supply capacity after repeated-sprint training in hypoxia combined with chronic hypoxic exposure', Journal of Applied Physiology (1985), vol. 124, no. 6, pp. 1403-1412. https://doi.org/10.1152/japplphysiol.00946.2017 |
| Publication Year: |
2018 |
| Subject Terms: |
Altitude training; Angiogenesis; Hypertrophy; Oxygen transport; Skeletal muscle; /dk/atira/pure/sustainabledevelopmentgoals/life_below_water; name=SDG 14 - Life Below Water |
| Description: |
In this study, we investigate adaptations in muscle oxidative capacity, fiber size and oxygen supply capacity in team-sport athletes after six repeated-sprint sessions in normobaric hypoxia or normoxia combined with 14 days of chronic normobaric hypoxic exposure. Lowland elite field hockey players resided at simulated altitude (14 h/day at 2,800 –3,000 m) and performed regular training plus six repeated-sprint sessions in normobaric hypoxia (3,000 m; LHTLH; n 6) or normoxia (0 m; LHTL; n 6) or lived at sea level with regular training only (LLTL; n 6). Muscle biopsies were obtained from the m. vastus lateralis before (pre), immediately after (post-1), and 3 wk after the intervention (post-2). Changes over time between groups were compared, including likelihood of the effect size (ES). Succinate dehydrogenase activity in LHTLH largely increased from pre to post-1 (~35%), likely more than LHTL and LLTL (ESs large-very large), and remained elevated in LHTLH at post-2 (~12%) vs. LHTL (ESs moderate-large). Fiber cross-sectional area remained fairly similar in LHTLH from pre to post-1 and post-2 but was increased at post-1 and post-2 in LHTL and LLTL (ES moderate-large). A unique observation was that LHTLH and LHTL, but not LLTL, improved their combination of fiber size and oxidative capacity. Small-to-moderate differences in oxygen supply capacity (i.e., myoglobin and capillarization) were observed between groups. In conclusion, elite team-sport athletes substantially increased their skeletal muscle oxidative capacity, while maintaining fiber size, after only 14 days of chronic hypoxic residence combined with six repeated-sprint training sessions in hypoxia. NEW & NOTEWORTHY Our novel findings show that elite team-sport athletes were able to substantially increase the skeletal muscle oxidative capacity in type I and II fibers (37 and 32%, respectively), while maintaining fiber size after only 14 days of chronic hypoxic residence combined with six repeated-sprint sessions in hypoxia. This increase in oxidative ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
8750-7587; 1522-1601 |
| Relation: |
info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/1871.1/86e7862a-163d-48f3-bc68-42c5195199fe; info:eu-repo/semantics/altIdentifier/pissn/8750-7587; info:eu-repo/semantics/altIdentifier/eissn/1522-1601 |
| DOI: |
10.1152/japplphysiol.00946.2017 |
| Availability: |
https://research.vu.nl/en/publications/86e7862a-163d-48f3-bc68-42c5195199fe; https://doi.org/10.1152/japplphysiol.00946.2017; https://hdl.handle.net/1871.1/86e7862a-163d-48f3-bc68-42c5195199fe; https://research.vu.nl/ws/files/170232548/Adaptations_in_muscle_oxidative_capacity_fiber_size_and_oxygen_supply_capacity_after_repeated_sprint_training_in_hypoxia_combined_with_chronic_hypoxic_exposure.pdf; https://www.scopus.com/pages/publications/85052015242; https://www.scopus.com/pages/publications/85052015242#tab=citedBy |
| Rights: |
info:eu-repo/semantics/openAccess ; https://ub.vu.nl/nl/onderwijs-onderzoek/open-access/b-you-share-we-care/end-user-agreement.aspx |
| Accession Number: |
edsbas.4CC3B39F |
| Database: |
BASE |