| Title: |
Elderly Onset of Functional Motor Disorders: Clinical Correlates from the Italian Registry |
| Authors: |
Geroin, C; Petracca, M; Di Tella, S; Marcuzzo, E; Erro, R; Cuoco, S; Ceravolo, R; Mazzucchi, S; Pilotto, A; Padovani, A; Romito, LM; Eleopra, R; Zappia, M; Nicoletti, A; Dallocchio, C; Arbasino, C; Bono, F; Laterza, V; Demartini, B; Gambini, O; Modugno, N; Olivola, E; Bonanni, L; Albanese, A; Ferrazzano, G; Tessitore, A; Lopiano, L; Calandra-Buonaura, G; Morgante, F; Esposito, M; Pisani, A; Manganotti, P; Tesolin, L; Teatini, F; Camozzi, S; Ercoli, T; Stocchi, F; Moja, MC; Defazio, G; Tinazzi, M |
| Publisher Information: |
Wiley |
| Publication Year: |
2024 |
| Collection: |
St George's University of London: Repository |
| Description: |
Background Functional motor disorders (FMD) are a frequent neurological condition affecting patients with movement disorders. Commonly described in younger adults, their manifestation can be also associated to an elderly onset. Objective To assess the prevalence and describe the clinical manifestations of FMD with elderly and younger onset and their relationship with demographical and clinical variables. Methods We recruited patients with a “clinically definite” diagnosis of FMD from the Italian Registry of FMD. Patients underwent extensive clinical assessments. For elderly onset, we set a chronological cut-off at 65 years or older according to WHO definition. Multivariate regression models were implemented to estimate adjusted odds ratio of elderly FMD onset related to clinical characteristics. Results Among the 410 patients, 34 (8.2%) experienced elderly-onset FMD, with a mean age at onset of 70.9 years. The most common phenotype was tremor (47.1%), followed by gait disorders, weakness, and dystonia (29.4%, 23.5%, 14.7%, respectively). Eleven elderly patients had a combined phenomenology: 9 exhibited two phenotypes, 2 had three phenotypes. Weakness was isolated in 3/8 patients and combined with another phenotype in 5/8, manifesting as paraplegia (n = 4); upper limb diplegia (n = 2), hemiparesis/hemiplegia (n = 1), and tetraparesis/tetraplegia (n= 1). Non-motor and other functional neurological disorders occurred more frequently in the younger group (89.1%) than the elderly (73.5%). Neurological and non-neurological comorbidities were more prevalent in the elderly group (82.4%) as opposed to the younger (32.7%). In a multivariate regression analysis, elderly-onset FMD was significantly associated with neurological comorbidities, including parkinsonism (OR 6.73) and cerebrovascular diseases (OR 5.48). Conclusions These results highlight the importance of achieving an accurate diagnosis of FMD in the elderly, as it is crucial for effectively managing FMD symptoms and addressing neurological comorbidities. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| Language: |
English |
| ISSN: |
2330-1619 |
| Relation: |
https://openaccess.sgul.ac.uk/id/eprint/115899/1/Movement%20Disord%20Clin%20Pract%20-%202023%20-%20Geroin%20-%20Elderly%20Onset%20of%20Functional%20Motor%20Disorders%20Clinical%20Correlates%20from%20the.pdf; https://openaccess.sgul.ac.uk/id/eprint/115899/6/mdc313916-sup-0001-tables1.docx; Geroin, C; Petracca, M; Di Tella, S; Marcuzzo, E; Erro, R; Cuoco, S; Ceravolo, R; Mazzucchi, S; Pilotto, A; Padovani, A; et al. Geroin, C; Petracca, M; Di Tella, S; Marcuzzo, E; Erro, R; Cuoco, S; Ceravolo, R; Mazzucchi, S; Pilotto, A; Padovani, A; Romito, LM; Eleopra, R; Zappia, M; Nicoletti, A; Dallocchio, C; Arbasino, C; Bono, F; Laterza, V; Demartini, B; Gambini, O; Modugno, N; Olivola, E; Bonanni, L; Albanese, A; Ferrazzano, G; Tessitore, A; Lopiano, L; Calandra-Buonaura, G; Morgante, F; Esposito, M; Pisani, A; Manganotti, P; Tesolin, L; Teatini, F; Camozzi, S; Ercoli, T; Stocchi, F; Moja, MC; Defazio, G; Tinazzi, M (2024) Elderly Onset of Functional Motor Disorders: Clinical Correlates from the Italian Registry. MOVEMENT DISORDERS CLINICAL PRACTICE, 11 (1). pp. 38-44. ISSN 2330-1619 https://doi.org/10.1002/mdc3.13916 SGUL Authors: Morgante, Francesca |
| DOI: |
10.1002/mdc3.13916 |
| Availability: |
https://openaccess.sgul.ac.uk/id/eprint/115899/; https://doi.org/10.1002/mdc3.13916 |
| Rights: |
cc_by_nc_nd_4 |
| Accession Number: |
edsbas.4CF78B04 |
| Database: |
BASE |