| Title: |
Measurements of 5,6-Orthoquinone, a Surrogate for the Presumed Active Primaquine Metabolite 5-Hydroxyprimaquine, in the Urine of Cambodian Adults |
| Authors: |
Vanachayangkul, Pattaraporn; Sea, Darapiseth; Wojnarski, Mariusz; Sok, Somethy; Kodchakorn, Chanikarn; Ta-aksorn, Winita; Hom, Sohei; Ittiverakul, Mali; Kuntawunginn, Worachet; Arsanok, Montri; Buathong, Nillawan; Heng, Thay Kheang; Nareth, Kong; Nou, Samon; Chandara, Sok; Ly, Sokna; Oung, Pheaktra; Vesely, Brian; Bennett, Jason; Reichard, Gregory; Pybus, Brandon; Lanteri, Charlotte; Saunders, David; Fukuda, Mark; Smith, Philip; Dysoley, Lek; Rekol, Huy; Waters, Norman C.; Spring, Michele |
| Contributors: |
DOD | Defense Health Agency; U.S. Department of Defense |
| Source: |
Antimicrobial Agents and Chemotherapy ; volume 66, issue 3 ; ISSN 0066-4804 1098-6596 |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2022 |
| Description: |
The active metabolites of primaquine, in particular 5-hydroxyprimaquine, likely responsible for the clearance of dormant hypnozoites, are produced through the hepatic CYP450 2D6 (CYP2D6) enzymatic pathway. With the inherent instability of 5-hydroxyprimaquine, a stable surrogate, 5,6-orthoquinone, can now be detected and measured in the urine as part of primaquine pharmacokinetic studies. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1128/aac.01821-21 |
| Availability: |
https://doi.org/10.1128/aac.01821-21; https://journals.asm.org/doi/pdf/10.1128/aac.01821-21 |
| Rights: |
https://doi.org/10.1128/ASMCopyrightv2 ; https://journals.asm.org/non-commercial-tdm-license |
| Accession Number: |
edsbas.4D0C8A8 |
| Database: |
BASE |