| Title: |
Altered insular functional connectivity in isolated REM sleep behavior disorder: a data-driven functional MRI study |
| Authors: |
Byun, JI; Cha, KS; Kim, M; Lee, WJ; Lee, HS; Sunwoo, JS; Shin, JW; Kim, TJ; Moon, J; Lee, ST; Jung, KH; Chu, K; Kim, MH; Kim, HJ; Shin, WC; Lee, SK; Jung, KY |
| Contributors: |
112418; Kim, TJ |
| Publication Year: |
2021 |
| Subject Terms: |
Brain; Cross-Sectional Studies; Humans; Magnetic Resonance Imaging; Polysomnography; REM Sleep Behavior Disorder; Cognitive function; Functional brain imaging; Multivariate pattern analysis (MVPA); Neuroimaging; psy; envir |
| Description: |
Objective: Functional connectivity (FC) changes can occur prior to structural changes. This study aimed to evaluate data-driven whole-brain FC associated with isolated rapid eye movement sleep behavior disorder (iRBD) using multivariate pattern analysis (MVPA). Methods: This was a cross-sectional study of 50 polysomnography-confirmed iRBD patients and 20 age- and sex-matched controls. We used MVPA implemented in the connectome-MVPA CONN toolbox to identify data-driven seed regions for post hoc seed-to-voxel connectivity analysis. The association between FC changes and clinical characteristics, including cognition, depression, autonomic function, and daytime sleepiness, was evaluated. Results: MVPA revealed one significant cluster located in the left posterior insular cortex. Seed-to-voxel FC analysis using the cluster as a seed showed significantly reduced FC with two clusters located in the precuneus in iRBD patients compared to the controls. The degree of FC was associated with the Montreal Cognitive Assessment-Korean version scores (r = 0.317, p = 0.025). Conclusion: This study emphasizes the insula as an important neural correlate associated with iRBD that was associated with cognitive function. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
http://repository.ajou.ac.kr/handle/201003/23682 |
| Availability: |
http://repository.ajou.ac.kr/handle/201003/23682 |
| Rights: |
undefined |
| Accession Number: |
edsbas.4D3B4D24 |
| Database: |
BASE |