Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
| Title: | Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK |
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| Authors: | Voysey, Merryn; Clemens, Sue Ann Costa; Madhi, Shabir A.; Weckx, Lily Y.; Folegatti, Pedro M.; Aley, Parvinder K.; Angus, Brian; Baillie, Vicky L.; Barnabas, Shaun L.; Bhorat, Qasim E.; Bibi, Sagida; Briner, Carmen; Cicconi, Paola; Collins, Andrea M.; Colin-Jones, Rachel; Cutland, Clare L.; Darton, Thomas C.; Dheda, Keertan; Duncan, Christopher J. A.; Emary, Katherine R. W.; Ewer, Katie J.; Fairlie, Lee; Faust, Saul N.; Feng, Shuo; Ferreira, Daniela M.; Finn, Adam; Goodman, Anna L.; Green, Catherine M.; Green, Christopher A.; Heath, Paul T.; Hill, Catherine; Hill, Helen; Hirsch, Ian; Hodgson, Susanne H. C.; Izu, Alane; Jackson, Susan; Jenkin, Daniel; Joe, Carina C. D.; Kerridge, Simon; Koen, Anthonet; Kwatra, Gaurav; Lazarus, Rajeka; Lawrie, Alison M.; Lelliott, Alice; Libri, Vincenzo; Lillie, Patrick J.; Mallory, Raburn; Mendes, Ana V .A.; Milan, Eveline P.; Minassian, Angela M.; McGregor, Alastair; Morrison, Hazel; Mujadidi, Yama F.; Nana, Anusha; O'Reilly, Peter J.; Padayachee, Sherman D.; Pittella, Ana; Plested, Emma; Pollock, Katrina M.; Ramasamy, Maheshi N.; Rhead, Sarah; Schwarzbold, Alexandre V.; Singh, Nisha; Smith, Andrew; Song, Rinn; Snape, Matthew D.; Sprinz, Eduardo; Sutherland, Rebecca K.; Tarrant, Richard; Thomson, Emma C.; Török, M Estée; Toshner, Mark; Turner, David P. J.; Vekemans, Johan; Villafana, Tonya L.; Watson, Marion E. E.; Williams, Christopher J.; Douglas, Alexander D.; Hill, Adrian V. S.; Lambe, Teresa; Gilbert, Sarah C; Pollard, Andrew J; Aban, Marites; Abayomi, Fatola; Abeyskera, Kushala; Aboagye, Jeremy; Adam, Matthew; Adams, Kirsty; Adamson, James; Adelaja, Yemi A.; Adlou, Syed; Ahmed, Khatija; Akhalwaya, Yasmeen; Akhalwaya, Saajida; Alcock, Andrew; Ali, Aabidah; Allen, Elizabeth R.; Allen, Lauren; Almeida, Thamires C. D. S. C; Alves, Mariana P.S.; Amorim, Fabio; Andritsou, Foteini; Anslow, Rachel; Appleby, Matthew; Arbe-Barnes, Edward H.; Ariaans, Mark P.; Arns, Beatriz; Arruda, Laiana; Awedetan, Gbadebo; Azi, Paula; Azi, Lorena; Babbage, Gavin; Bailey, Catherine; Baker, Kenneth F.; Baker, Megan; Baker, Natalie; Baker, Philip; Baldwin, Lisa; Baleanu, Ioana; Bandeira, Danieli; Bara, Anna; Barbosa, Marcella A.S.; Barker, Debbie; Barlow, Gavin D.; Barnes, Eleanor; Barr, Andrew S.; Barrett, Jordan R.; Barrett, Jessica; Bates, Louise; Batten, Alexander; Beadon, Kirsten; Beales, Emily; Beckley, Rebecca; Belij-Rammerstorfer, Sandra; Bell, Jonathan; Bellamy, Duncan; Bellei, Nancy; Belton, Sue; Berg, Adam; Bermejo, Laura; Berrie, Eleanor; Berry, Lisa; Berzenyi, Daniella; Beveridge, Amy; Bewley, Kevin R.; Bexhell, Helen; Bhikha, Sutika; Bhorat, Asad E.; Bhorat, Zaheda E.; Bijker, Else; Birch, Geeta; Birch, Sarah; Bird, Adam; Bird, Olivia; Bisnauthsing, Karen; Bittaye, Mustapha; Blackstone, Katherine; Blackwell, Luke; Bletchly, Heather; Blundell, Caitlin L.; Blundell, Susannah R.; Bodalia, Pritesh; Boettger, Bruno C.; Bolam, Emma; Boland, Elena; Bormans, Daan; Borthwick, Nicola; Bowring, Francesca; Boyd, Amy; Bradley, Penny; Brenner, Tanja; Brown, Phillip; Brown, Claire; Brown-O'Sullivan, Charlie; Bruce, Scott; Brunt, Emily; Buchan, Ruaridh; Budd, William; Bulbulia, Yusuf A.; Bull, Melanie; Burbage, Jamie; Burhan, Hassan; Burn, Aileen; Buttigieg, Karen R.; Byard, Nicholas; Cabera Puig, Ingrid; Calderon, Gloria; Calvert, Anna; Camara, Susana; Cao, Michelangelo; Cappuccini, Federica; Cardoso, João R.; Carr, Melanie; Carroll, Miles W.; Carson-Stevens, Andrew; Carvalho, Yasmin de M.; Carvalho, José A.M.; Casey, Helen R.; Cashen, Paul; Castro, Thais; Castro, Lucia Carratala; Cathie, Katrina; Cavey, Ana; Cerbino-Neto, José; Chadwick, Jim; Chapman, David; Charlton, Sue; Chelysheva, Irina; Chester, Oliver; Chita, Sunder; Cho, Jee-Sun; Cifuentes, Liliana; Clark, Elizabeth; Clark, Matthew; Clarke, Andrea; Clutterbuck, Elizabeth A.; Collins, Sarah L.K.; Conlon, Christopher P.; Connarty, Sean; Coombes, Naomi; Cooper, Cushla; Cooper, Rachel; Cornelissen, Lynne; Corrah, Tumena; Cosgrove, Catherine; Cox, Tony; Crocker, Wendy E.M.; Crosbie, Sarah; Cullen, Lorraine; Cullen, Dan; Cunha, Debora R.M.F.; Cunningham, Christina; Cuthbertson, Fiona C.; Da Guarda, Suzete N. Farias; da Silva, Larissa P.; Damratoski, Brad E.; Danos, Zsofia; Dantas, Maria T.D.C.; Darroch, Paula; Datoo, Mehreen S.; Datta, Chandrabali; Davids, Malika; Davies, Sarah L.; Davies, Hannah; Davis, Elizabeth; Davis, Judith; Davis, John; De Nobrega, Maristela M.D.; De Oliveira Kalid, Lis Moreno; Dearlove, David; Demissie, Tesfaye; Desai, Amisha; Di Marco, Stefania; Di Maso, Claudio; Dinelli, Maria I.S.; Dinesh, Tanya; Docksey, Claire; Dold, Christina; Dong, Tao; Donnellan, Francesca R.; Dos Santos, Tannyth; dos Santos, Thainá G.; Dos Santos, Erika Pachecho; Douglas, Naomi; Downing, Charlotte; Drake, Jonathan; Drake-Brockman, Rachael; Driver, Kimberley; Drury, Ruth; Dunachie, Susanna J.; Durham, Benjamin S.; Dutra, Lidiana; Easom, Nicholas J.W.; van Eck, Samual; Edwards, Mandy; Edwards, Nick J.; El Muhanna, Omar M.; Elias, Sean C.; Elmore, Mike; English, Marcus; Esmail, Alisgair; Essack, Yakub Moosa; Farmer, Eoghan; Farooq, Mutjaba; Farrar, Madi; Farrugia, Leonard; Faulkner, Beverley; Fedosyuk, Sofiya; Felle, Sally; Ferreira Da Silva, Carla; Field, Samantha; Fisher, Richard; Flaxman, Amy; Fletcher, James; Fofie, Hazel; Fok, Henry; Ford, Karen J.; Fowler, Jamie; Fraiman, Pedro H.A.; Francis, Emma; Franco, Marilia M.; Frater, John; Freire, Marilúcia S.M.; Fry, Samantha H.; Fudge, Sabrina; Furze, Julie; Fuskova, Michelle; Galian-Rubio, Pablo; Galiza, Eva; Garlant, Harriet; Gavrila, Madita; Geddes, Ailsa; Gibbons, Karyna A.; Gilbride, Ciaran; Gill, Hardeep; Glynn, Sharon; Godwin, Kerry; Gokani, Karishma; Goldoni, Ursula Carvalho; Goncalves, Maria; Gonzalez, Isabela G.S.; Goodwin, Jayne; Goondiwala, Amina; Gordon-Quayle, Katherine; Gorini, Giacomo; Grab, Janet; Gracie, Lara; Greenland, Melanie; Greenwood, Nicola; Greffrath, Johann; Groenewald, Marisa M.; Grossi, Leonardo; Gupta, Gaurav; Hackett, Mark; Hallis, Bassam; Hamaluba, Mainga; Hamilton, Elizabeth; Hammersley, Daniel; Hanrath, Aidan T.; Hanumunthadu, Brama; Harris, Stephanie A.; Harris, Clair; Harris, Tara; Harrison, Thomas D.; Harrison, Daisy; Hart, Thomas C.; Hartnell, Birgit; Hassan, Shadin; Haughney, John; Hawkins, Sophia; Hay, Jodie; Head, Ian; Henry, John; Hermosin Herrera, Macarena; Hettle, David B.; Hill, Jennifer; Hodges, Gina; Horne, Elizea; Hou, Mimi M.; Houlihan, Catherine; Howe, Elizabeth; Howell, Nicola; Humphreys, Jonathan; Humphries, Holly E.; Hurley, Katrina; Huson, Claire; Hyder-Wright, Angela; Hyamns, Catherine; Ikram, Sabina; Ishwarbhai, Alka; Ivan, Monica; Iveson, Poppy; Iyer, Vidyashankara; Jackson, Frederic; De Jager, Jeanne; Jaumdally, Shameem; Jeffers, Helen; Jesudason, Natasha; Jones, Bryony; Jones, Kathryn; Jones, Elizabeth; Jones, Christopher; Jorge, Marianna Rocha; Jose, Aylin; Joshi, Amar; Júnior, Eduardo A.M.S.; Kadziola, Joanne; Kailath, Reshma; Kana, Faeeza; Karampatsas, Konstantinos; Kasanyinga, Mwila; Keen, Jade; Kelly, Elizabeth J.; Kelly, Dearbhla M.; Kelly, Debbie; Kelly, Sarah; Kerr, David; Kfouri, Renato de Ávila; Khan, Liaquat; Khozoee, Baktash; Kidd, Sarah; Killen, Annabel; Kinch, Jasmin; Kinch, Patrick; King, Lloyd D.W.; King, Thomas B.; Kingham, Lucy; Klenerman, Paul; Knapper, Francesca; Knight, Julian C.; Knott, Daniel; Koleva, Stanislava; Lang, Matilda; Lang, Gail; Larkworthy, Colin W.; Larwood, Jessica P.J.; Law, Rebecca; Lazarus, Erica M.; Leach, Amanda; Lees, Emily A.; Lemm, Nana-Marie; Lessa, Alvaro; Leung, Stephanie; Li, Yuanyuan; Lias, Amelia M.; Liatsikos, Kostas; Linder, Aline; Lipworth, Samuel; Liu, Shuchang; Liu, Xinxue; Lloyd, Adam; Lloyd, Stephanie; Loew, Lisa; Lopez Ramon, Raquel; Lora, Leandro; Lowthorpe, Vicki; Luz, Kleber; MacDonald, Jonathan C.; MacGregor, Gordon; Madhavan, Meera; Mainwaring, David O.; Makambwa, Edson; Makinson, Rebecca; Malahleha, Mookho; Malamatsho, Ross; Mallett, Garry; Mansatta, Kushal; Maoko, Takalani; Mapetla, Katlego; Marchevsky, Natalie G.; Marinou, Spyridoula; Marlow, Emma; Marques, Gabriela N.; Marriott, Paula; Marshall, Richard P.; Marshall, Julia L.; Martins, Flávia J.; Masenya, Masebole; Masilela, Mduduzi; Masters, Shauna K.; Mathew, Moncy; Matlebjane, Hosea; Matshidiso, Kedidimetse; Mazur, Olga; Mazzella, Andrea; McCaughan, Hugh; McEwan, Joanne; McGlashan, Joanna; McInroy, Lorna; McIntyre, Zoe; McLenaghan, Daniela; McRobert, Nicky; McSwiggan, Steve; Megson, Clare; Mehdipour, Savviz; Meijs, Wilma; Mendonça, Renata N.Á.; Mentzer, Alexander J.; Mirtorabi, Neginsadat; Mitton, Celia; Mnyakeni, Sibusiso; Moghaddas, Fiona; Molapo, Kgaogelo; Moloi, Mapule; Moore, Maria; Moraes-Pinto, M. Isabel; Moran, Marni; Morey, Ella; Morgans, Róisín; Morris, Susan; Morris, Sheila; Morris, Helen C.; Morselli, Franca; Morshead, Gertraud; Morter, Richard; Mottal, Lynelle; Moultrie, Andrew; Moya, Nathifa; Mpelembue, Mushiya; Msomi, Sibekezelo; Mugodi, Yvonne; Mukhopadhyay, Ekta; Muller, Jilly; Munro, Alasdair; Munro, Claire; Murphy, Sarah; Mweu, Philomena; Myasaki, Celia Hatsuko; Naik, Gurudutt; Naker, Kush; Nastouli, Eleni; Nazir, Abida; Ndlovu, Bongani; Neffa, Fabio; Njenga, Cecilia; Noal, Helena; Noé, Andrés; Novaes, Gabrielle; Nugent, Fay L.; Nunes, Géssika; O'Brien, Katie; O'Connor, Daniel; Odam, Miranda; Oelofse, Suzette; Oguti, Blanche; Olchawski, Victoria; Oldfield, Neil J.; Oliveira, Marianne G.; Oliveira, Catarina; Oosthuizen, Angela; O'Reilly, Paula; Osborne, Piper; Owen, David R.J.; Owen, Lydia; Owens, Daniel; Owino, Nelly; Pacurar, Mihaela; Paiva, Brenda V.B.; Palhares, Edna M.F.; Palmer, Susan; Parkinson, Sivapriyai; Parracho, Helena M.R.T.; Parsons, Karen; Patel, Dipak; Patel, Bhumika; Patel, Faeezah; Patel, Kelly; Patrick-Smith, Maia; Payne, Ruth O.; Peng, Yanchun; Penn, Elizabeth J.; Pennington, Anna; Peralta Alvarez, Marco Polo; Perring, James; Perry, Nicola; Perumal, Rubeshan; Petkar, Sahir; Philip, Tricia; Phillips, Daniel J.; Phillips, Jennifer; Phohu, Mary Kgomotso; Pickup, Lorinda; Pieterse, Sonja; Piper, Jo; Pipini, Dimitra; Plank, Mary; Du Plessis, Joan; Pollard, Samuel; Pooley, Jennifer; Pooran, Anil; Poulton, Ian; Powers, Claire; Presa, Fernando B.; Price, David A.; Price, Vivien; Primeira, Marcelo; Proud, Pamela C.; Provstgaard-Morys, Samuel; Pueschel, Sophie; Pulido, David; Quaid, Sheena; Rabara, Ria; Radford, Alexandra; Radia, Kajal; Rajapaska, Durga; Rajeswaran, Thurkka; Ramos, Alberto San Francisco; Ramos Lopez, Fernando; Rampling, Tommy; Rand, Jade; Ratcliffe, Helen; Rawlinson, Tom; Rea, David; Rees, Byron; Reiné, Jesús; Resuello-Dauti, Mila; Reyes Pabon, Emilia; Ribiero, Carla M.; Ricamara, Marivic; Richter, Alex; Ritchie, Neil; Ritchie, Adam J.; Robbins, Alexander J.; Roberts, Hannah; Robinson, Ryan E.; Robinson, Hannah; Rocchetti, Talita T.; Rocha, Beatriz Pinho; Roche, Sophie; Rollier, Christine; Rose, Louisa; Ross Russell, Amy L.; Rossouw, Lindie; Royal, Simon; Rudiansyah, Indra; Ruiz, Sarah; Saich, Stephen; Sala, Claudia; Sale, Jessica; Salman, Ahmed M.; Salvador, Natalia; Salvador, Stephannie; Sampaio, Milla; Samson, Annette D.; Sanchez-Gonzalez, Amada; Sanders, Helen; Sanders, Katherine; Santos, Erika; Santos Guerra, Mayara F.S.; Satti, Iman; Saunders, Jack E.; Saunders, Caroline; Sayed, Aakifah; Schim van der Loeff, Ina; Schmid, Annina B.; Schofield, Ella; Screaton, Gavin; Seddiqi, Samiullah; Segireddy, Rameswara R.; Senger, Roberta; Serrano, Sonia; Shah, Rajiv; Shaik, Imam; Sharpe, Hannah E.; Sharrocks, Katherine; Shaw, Robert; Shea, Adam; Shepherd, Amy; Shepherd, James G.; Shiham, Farah; Sidhom, Emad; Silk, Sarah E.; da Silva Moraes, Antonio Carlos; Silva-Junior, Gilberto; Silva-Reyes, Laura; Silveira, Anderson D.; Silveira, Mariana B.V.; Sinha, Jaisi; Skelly, Donal T.; Smith, Daniel C.; Smith, Nick; Smith, Holly E.; Smith, David J.; Smith, Catherine C.; Soares, Airanuédida; Soares, Tiago; Solórzano, Carla; Sorio, Guilherme L.; Sorley, Kim; Sosa-Rodriguez, Tiffany; Souza, Cinthia M.C.D.L.; Souza, Bruno S.D.F.; Souza, Alessandra R.; Spencer, Alexandra J.; Spina, Fernanda; Spoors, Louise; Stafford, Lizzie; Stamford, Imogen; Starinskij, Igor; Stein, Ricardo; Steven, Jill; Stockdale, Lisa; Stockwell, Lisa V.; Strickland, Louise H.; Stuart, Arabella C.; Sturdy, Ann; Sutton, Natalina; Szigeti, Anna; Tahiri-Alaoui, Abdessamad; Tanner, Rachel; Taoushanis, Carol; Tarr, Alexander W.; Taylor, Keja; Taylor, Ursula; Taylor, Iona Jennifer; Taylor, Justin; te Water Naude, Rebecca; Themistocleous, Yrene; Themistocleous, Andreas; Thomas, Merin; Thomas, Kelly; Thomas, Tonia M.; Thombrayil, Asha; Thompson, Fawziyah; Thompson, Amber; Thompson, Kevin; Thompson, Ameeka; Thomson, Julia; Thornton-Jones, Viv; Tighe, Patrick J.; Tinoco, Lygia Accioly; Tiongson, Gerlynn; Tladinyane, Bonolo; Tomasicchio, Michele; Tomic, Adriana; Tonks, Susan; Tran, Nguyen; Tree, Julia; Trillana, Gerry; Trinham, Charlotte; Trivett, Rose; Truby, Adam; Tsheko, Betty Lebogang; Turabi, Aadil; Turner, Richard; Turner, Cheryl; Ulaszewska, Marta; Underwood, Benjamin R.; Varughese, Rachel; Verbart, Dennis; Verheul, Marije; Vichos, Iason; Vieira, Taiane; Waddington, Claire S.; Walker, Laura; Wallis, Erica; Wand, Matthew; Warbick, Deborah; Wardell, Theresa; Warimwe, George; Warren, Sarah C.; Watkins, Bridget; Watson, Ekaterina; Webb, Stewart; Webb-Bridges, Alice; Webster, Angela; Welch, Jessica; Wells, Jeanette; West, Alison; White, Caroline; White, Rachel; Williams, Paul; Williams, Rachel L.; Winslow, Rebecca; Woodyer, Mark; Worth, Andrew T.; Wright, Danny; Wroblewska, Marzena; Yao, Andy; Zimmer, Rafael; Zizi, Dalila; Zuidewind, Peter |
| Publisher Information: | Elsevier |
| Publication Year: | 2021 |
| Collection: | Cardiff University: ORCA (Online Research @ Cardiff) |
| Description: | Background A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. Methods This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. Findings Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] ... |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| Relation: | https://orca.cardiff.ac.uk/id/eprint/136956/1/Safety%20and%20efficacy%20of%20the%20ChAdOx1%20nCoV-19%20vaccine%20%28AZD1222%29%20against%20SARS-CoV-2.pdf; Voysey, Merryn, Clemens, Sue Ann Costa, Madhi, Shabir A., Weckx, Lily Y., Folegatti, Pedro M., Aley, Parvinder K., Angus, Brian, Baillie, Vicky L., Barnabas, Shaun L., Bhorat, Qasim E., Bibi, Sagida, Briner, Carmen, Cicconi, Paola, Collins, Andrea M., Colin-Jones, Rachel, Cutland, Clare L., Darton, Thomas C., Dheda, Keertan, Duncan, Christopher J. A., Emary, Katherine R. W., Ewer, Katie J., Fairlie, Lee, Faust, Saul N., Feng, Shuo, Ferreira, Daniela M., Finn, Adam, Goodman, Anna L., Green, Catherine M., Green, Christopher A., Heath, Paul T., Hill, Catherine, Hill, Helen, Hirsch, Ian, Hodgson, Susanne H. C., Izu, Alane, Jackson, Susan, Jenkin, Daniel, Joe, Carina C. D., Kerridge, Simon, Koen, Anthonet, Kwatra, Gaurav, Lazarus, Rajeka, Lawrie, Alison M., Lelliott, Alice, Libri, Vincenzo, Lillie, Patrick J., Mallory, Raburn, Mendes, Ana V .A., Milan, Eveline P., Minassian, Angela M., McGregor, Alastair, Morrison, Hazel, Mujadidi, Yama F., Nana, Anusha, O'Reilly, Peter J., Padayachee, Sherman D., Pittella, Ana, Plested, Emma, Pollock, Katrina M., Ramasamy, Maheshi N., Rhead, Sarah, Schwarzbold, Alexandre V., Singh, Nisha, Smith, Andrew, Song, Rinn, Snape, Matthew D., Sprinz, Eduardo, Sutherland, Rebecca K., Tarrant, Richard, Thomson, Emma C., Török, M Estée, Toshner, Mark, Turner, David P. J., Vekemans, Johan, Villafana, Tonya L., Watson, Marion E. E., Williams, Christopher J., Douglas, Alexander D., Hill, Adrian V. S., Lambe, Teresa, Gilbert, Sarah C, Pollard, Andrew J, Aban, Marites, Abayomi, Fatola, Abeyskera, Kushala, Aboagye, Jeremy, Adam, Matthew, Adams, Kirsty, Adamson, James, Adelaja, Yemi A., Adlou, Syed, Ahmed, Khatija, Akhalwaya, Yasmeen, Akhalwaya, Saajida, Alcock, Andrew, Ali, Aabidah, Allen, Elizabeth R., Allen, Lauren, Almeida, Thamires C. D. S. C, Alves, Mariana P.S., Amorim, Fabio, Andritsou, Foteini, Anslow, Rachel, Appleby, Matthew, Arbe-Barnes, Edward H., Ariaans, Mark P., Arns, Beatriz, Arruda, Laiana, Awedetan, Gbadebo, Azi, Paula, Azi, Lorena, Babbage, Gavin, Bailey, Catherine, Baker, Kenneth F., Baker, Megan, Baker, Natalie, Baker, Philip, Baldwin, Lisa, Baleanu, Ioana, Bandeira, Danieli, Bara, Anna, Barbosa, Marcella A.S., Barker, Debbie, Barlow, Gavin D., Barnes, Eleanor, Barr, Andrew S., Barrett, Jordan R., Barrett, Jessica, Bates, Louise, Batten, Alexander, Beadon, Kirsten, Beales, Emily, Beckley, Rebecca, Belij-Rammerstorfer, Sandra, Bell, Jonathan, Bellamy, Duncan, Bellei, Nancy, Belton, Sue, Berg, Adam, Bermejo, Laura, Berrie, Eleanor, Berry, Lisa, Berzenyi, Daniella, Beveridge, Amy, Bewley, Kevin R., Bexhell, Helen, Bhikha, Sutika, Bhorat, Asad E., Bhorat, Zaheda E., Bijker, Else, Birch, Geeta, Birch, Sarah, Bird, Adam, Bird, Olivia, Bisnauthsing, Karen, Bittaye, Mustapha, Blackstone, Katherine, Blackwell, Luke, Bletchly, Heather, Blundell, Caitlin L., Blundell, Susannah R., Bodalia, Pritesh, Boettger, Bruno C., Bolam, Emma, Boland, Elena, Bormans, Daan, Borthwick, Nicola, Bowring, Francesca, Boyd, Amy, Bradley, Penny, Brenner, Tanja, Brown, Phillip, Brown, Claire, Brown-O'Sullivan, Charlie, Bruce, Scott, Brunt, Emily, Buchan, Ruaridh, Budd, William, Bulbulia, Yusuf A., Bull, Melanie, Burbage, Jamie, Burhan, Hassan, Burn, Aileen, Buttigieg, Karen R., Byard, Nicholas, Cabera Puig, Ingrid, Calderon, Gloria, Calvert, Anna, Camara, Susana, Cao, Michelangelo, Cappuccini, Federica, Cardoso, João R., Carr, Melanie, Carroll, Miles W., Carson-Stevens, Andrew https://orca.cardiff.ac.uk/view/cardiffauthors/A051118V.html orcid:0000-0002-7580-7699 orcid:0000-0002-7580-7699, Carvalho, Yasmin de M., Carvalho, José A.M., Casey, Helen R., Cashen, Paul, Castro, Thais, Castro, Lucia Carratala, Cathie, Katrina, Cavey, Ana, Cerbino-Neto, José, Chadwick, Jim, Chapman, David, Charlton, Sue, Chelysheva, Irina, Chester, Oliver, Chita, Sunder, Cho, Jee-Sun, Cifuentes, Liliana, Clark, Elizabeth, Clark, Matthew, Clarke, Andrea, Clutterbuck, Elizabeth A., Collins, Sarah L.K., Conlon, Christopher P., Connarty, Sean, Coombes, Naomi, Cooper, Cushla, Cooper, Rachel, Cornelissen, Lynne, Corrah, Tumena, Cosgrove, Catherine, Cox, Tony, Crocker, Wendy E.M., Crosbie, Sarah, Cullen, Lorraine, Cullen, Dan, Cunha, Debora R.M.F., Cunningham, Christina, Cuthbertson, Fiona C., Da Guarda, Suzete N. 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Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet 397 (10269) , pp. 99-111. 10.1016/S0140-6736(20)32661-1 https://doi.org/10.1016/S0140-6736%2820%2932661-1 file https://orca.cardiff.ac.uk/id/eprint/136956/1/Safety%20and%20efficacy%20of%20the%20ChAdOx1%20nCoV-19%20vaccine%20%28AZD1222%29%20against%20SARS-CoV-2.pdf |
| DOI: | 10.1016/S0140-6736(20)32661-1 |
| Availability: | https://orca.cardiff.ac.uk/id/eprint/136956/; https://doi.org/10.1016/S0140-6736(20)32661-1 |
| Rights: | cc_by |
| Accession Number: | edsbas.4D6281D9 |
| Database: | BASE |