| Title: |
The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism |
| Authors: |
Maiorino, Teresa; Avitabile, Marianna; Aievola, Vincenzo; Montella, Annalaura; Lasorsa, Vito A.; Bonfiglio, Ferdinando; Cantalupo, Mariagrazia; Cantalupo, Sueva; Estinto, Gilda; Tirelli, Matilde; Morini, Martina; Ardito, Martina; Eva, Alessandra; Cerbone, Vincenza; Mauriello, Lucia; Caterino, Marianna; Ruoppolo, Margherita; Maris, John M.; Diskin, Sharon J.; Iolascon, Achille; Capasso, Mario |
| Contributors: |
Fondazione Italiana per la Lotta al Neuroblastoma; Associazione Italiana per la Ricerca sul Cancro; National Institutes of Health |
| Source: |
Advanced Science ; volume 12, issue 33 ; ISSN 2198-3844 2198-3844 |
| Publisher Information: |
Wiley |
| Publication Year: |
2025 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
A Genome‐wide association study (GWAS) on a European‐American cohort identified chr11p11.2 as a neuroblastoma predisposition locus. Combining in‐house and public genomic data from neuroblastoma cell lines, this work implicates rs2863002 as the candidate causal variant at the 11p11.2 locus, confirming its cis‐regulatory activity through a luciferase reporter assay. The genetic association of rs2863002 with neuroblastoma risk is validated in an Italian case‐control cohort. Using ChIP‐qPCR, Hi‐C, and CRISPR genome editing, this work deciphers the regulatory mechanisms at the risk locus, demonstrating that the rs2863002‐C risk allele regulates HSD17B12 expression and reduces GATA3 binding affinity. In vitro functional assays and targeted lipidomic analyses reveal the involvement of the rs2863002‐C risk allele in tumorigenicity and modulation of lipid metabolism in neuroblastoma cells through HSD17B12 regulation. This study provides new insights into the genetic basis of neuroblastoma and underscores the importance of post‐GWAS functional characterization of risk loci in uncovering relevant biological findings for understanding complex diseases. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/advs.202415181 |
| Availability: |
https://doi.org/10.1002/advs.202415181; https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202415181 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.4DAB73E |
| Database: |
BASE |