Clinical characteristics, therapy and outcome of bloodstream infections caused by vancomycin-resistant enterococci: a multicentre clinical experience
| Title: | Clinical characteristics, therapy and outcome of bloodstream infections caused by vancomycin-resistant enterococci: a multicentre clinical experience |
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| Authors: | Serapide F.; Serraino R.; Spadafora L.; Bernardi M.; Brucci G.; Cattardico G.; Corcione S.; De Benedetto I.; Del Monte M.; Limongelli A.; Giacobbe D. R.; Graziano E.; Meschiari M.; Pinna S. M.; Peghin M.; Tiseo G.; Vena A.; Romeo F.; Sarto G.; Bassetti M.; Biondi-Zoccai G.; De Rosa F. G.; Falcone M.; Grossi P. A.; Mussini C.; Russo A. |
| Contributors: | Serapide, F.; Serraino, R.; Spadafora, L.; Bernardi, M.; Brucci, G.; Cattardico, G.; Corcione, S.; De Benedetto, I.; Del Monte, M.; Limongelli, A.; Giacobbe, D. R.; Graziano, E.; Meschiari, M.; Pinna, S. M.; Peghin, M.; Tiseo, G.; Vena, A.; Romeo, F.; Sarto, G.; Bassetti, M.; Biondi-Zoccai, G.; De Rosa, F. G.; Falcone, M.; Grossi, P. A.; Mussini, C.; Russo, A. |
| Publication Year: | 2025 |
| Collection: | IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria) |
| Description: | Objectives: Bloodstream infections (BSIs) due to vancomycin-resistant Enterococcus spp. (VRE) are considered a predictor of mortality among frail patients. The aim of this study was to evaluate the risk factors associated with 30 day mortality and relapse of infection in enterococcal BSI caused by VRE and to evaluate the impact of antibiotic regimens in targeted therapy. Methods: We conducted a retrospective study of consecutive hospitalized patients in six teaching hospitals from August 2016 to August 2022 in Italy. All adult patients with a documented VRE BSI were included. Results: We enrolled 517 consecutive hospitalized patients with VRE BSI; of these BSIs 496 (96.5%) were caused by Enterococcus faecium and 26 (5.1%) by Enterococcus faecalis. The most frequently used antibiotics as backbone were linezolid (48.1%) and daptomycin (43.7%). Overall, the 30 day mortality was 32.1%. Upon Cox regression analysis, the risk factor independently associated with 30 day mortality was Charlson comorbidity index >3 points (P < 0.001), whereas a Pitt score |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:001429357300001; volume:80; issue:5; firstpage:1241; lastpage:1247; numberofpages:7; journal:JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY; https://hdl.handle.net/11383/2205371 |
| DOI: | 10.1093/jac/dkaf055 |
| Availability: | https://hdl.handle.net/11383/2205371; https://doi.org/10.1093/jac/dkaf055 |
| Accession Number: | edsbas.4DBDCFF9 |
| Database: | BASE |