| Title: |
Maternal dietary inflammatory status and serum neopterin during pregnancy: influence on infantile atopic eczema in the offspring |
| Authors: |
El-Heis, Sarah; Crozier, Sarah R.; Loo, Evelyn X.; Tham, Elizabeth H.; Harvey, Nicholas C.; Inskip, Hazel M; Godfrey, Keith M. |
| Publication Year: |
2025 |
| Collection: |
University of Southampton: e-Prints Soton |
| Description: |
Background: a protective influence of maternal inflammatory status on infantile atopic eczema risk has been proposed, but few studies have investigated these potential links. We examined the associations between energy-adjusted dietary inflammatory index (E-DII) scores indicative of an inflammatory dietary pattern, maternal serum neopterin levels, a biomarker elevated in Th1 immune activation, and infantile risk of atopic eczema. Methods: within the UK Southampton Women's Survey, mothers' diets were recorded using questionnaires at preconception, early and late pregnancy and E-DII scores derived. 3006 deliveries of live born infants with no major congenital growth abnormalities who were assessed for atopic eczema at 6 or 12 months (ascertained using the UK Working Party Diagnostic Criteria [n = 2955 and 2871, respectively]). A sub-sample of 497 mothers had serum neopterin measured in late pregnancy. Results: unadjusted analyses showed that higher E-DII in preconception and late pregnancy was associated with a lower risk of eczema at ages 6 and 12 months. After adjusting for maternal BMI, age, parity, education, smoking during pregnancy, breastfeeding duration and sex, higher E-DII in late pregnancy was associated with reduced risks of eczema at age 6 and 12 months (OR 0.89 [95% CI 0.81, 0.99], p = 0.03 and OR 0.91 [0.82, 1.00], p = 0.05, respectively). Consistent with this, higher maternal serum neopterin was associated with a lower risk of eczema at ages 6 months (OR 0.72 [0.51, 1.01], p = 0.05) and 12 months (OR 0.71 [0.53, 0.96], p = 0.03). Conclusions: the findings suggest that a pro-inflammatory maternal diet and an inflammatory maternal environment during pregnancy may protect the developing infant from Th2 driven inflammation and lower the risk of infantile atopic eczema. TRIAL REGISTRATION: NCT04715945. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/octet-stream |
| Language: |
English |
| Relation: |
https://eprints.soton.ac.uk/504987/1/Clinical_Translational_All_-_2025_-_El_Heis_-_Maternal_Dietary_Inflammatory_Status_and_Serum_Neopterin_During_Pregnancy_.pdf.crdownload; El-Heis, Sarah, Crozier, Sarah R., Loo, Evelyn X., Tham, Elizabeth H., Harvey, Nicholas C., Inskip, Hazel M and Godfrey, Keith M. , Southampton Women's Survey Study Group (2025) Maternal dietary inflammatory status and serum neopterin during pregnancy: influence on infantile atopic eczema in the offspring. Clinical and Translational Allergy, 15 (7), e70080, [e70080]. (doi:10.1002/clt2.70080 ). |
| Availability: |
https://eprints.soton.ac.uk/504987/ |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.4DFCB78A |
| Database: |
BASE |