| Title: |
Neural primacy of the salience processing system in schizophrenia |
| Authors: |
Palaniyappan, Lena; Simmonite, M.; White, T.P.; Liddle, E.B.; Liddle, P.F. |
| Publisher Information: |
Elsevier |
| Publication Year: |
2013 |
| Collection: |
University of Nottingham: Repository@Nottingham |
| Description: |
For effective information processing, two large-scale distributed neural networks appear to be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (DLPFC) and a salience system anchored on the anterior insula. Aberrant interaction among distributed networks is a feature of psychiatric disorders such as schizophrenia. We used whole-brain Granger causal modeling using resting fMRI and observed a significant failure of both the feedforward and reciprocal influence between the insula and the DLPFC in schizophrenia. Further, a significant failure of directed influence from bilateral visual cortices to the insula was also seen in patients. These findings provide compelling evidence for a breakdown of the salience-execution loop in the clinical expression of psychosis. In addition, this offers a parsimonious explanation for the often-observed “frontal inefficiency,” the failure to recruit prefrontal system when salient or novel information becomes available in patients with schizophrenia. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://nottingham-repository.worktribe.com/output/716930; Neuron; Volume 79; Issue 4 |
| DOI: |
10.1016/j.neuron.2013.06.027 |
| Availability: |
https://doi.org/10.1016/j.neuron.2013.06.027; https://nottingham-repository.worktribe.com/file/716930/1/neurom.pdf; https://nottingham-repository.worktribe.com/output/716930 |
| Rights: |
openAccess |
| Accession Number: |
edsbas.4EB838EC |
| Database: |
BASE |