| Title: |
Cross-Sectional Retrospective Study to Identify Clinical and Radiographic Features Associated With VZV Reactivation in Cryptogenic Stroke Patients With CSF Testing |
| Authors: |
Bakradze, Ekaterina; Esenwa, Charles C.; Schmid, D. Scott; Kirchoff-Torres, Kathryn F.; Antoniello, Daniel; Mabie, Peter C.; Labovitz, Daniel L.; Miao, Congrong; Liberman, Ava L. |
| Source: |
The Neurohospitalist ; volume 12, issue 3, page 437-443 ; ISSN 1941-8744 1941-8752 |
| Publisher Information: |
SAGE Publications |
| Publication Year: |
2022 |
| Description: |
Background and Purpose: A large proportion of ischemic stroke patients lack a definitive stroke etiology despite extensive diagnostic testing. Varicella-Zoster Virus (VZV) can directly invade blood vessels causing vasculitis and may be associated with cryptogenic stroke (CS). Methods: We conducted a retrospective cross-sectional study of CS patients tested for VZV. The following were considered evidence of VZV reactivation (VZV+): positive CSF VZV PCR, anti-VZV IgM in CSF, or anti-VZV IgG CSF/serum ratio of 1:10 or higher. We describe the cohort, report VZV+ proportion with 95% confidence intervals (CI) determined with the Wald method, and compare patient groups using standard statistical tests. Results: A total of 72 CS patients met full study inclusion criteria. Most of the patients were |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1177/19418744221075123 |
| Availability: |
https://doi.org/10.1177/19418744221075123; https://journals.sagepub.com/doi/pdf/10.1177/19418744221075123; https://journals.sagepub.com/doi/full-xml/10.1177/19418744221075123 |
| Rights: |
https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: |
edsbas.4ED28689 |
| Database: |
BASE |