| Title: |
The role of accelerometer-derived sleep traits on glycated haemoglobin and glucose levels: a Mendelian randomization study |
| Authors: |
Liu, J; Richmond, RC; Anderson, EL; Bowden, J; Barry, CS; Dashti, HS; Daghlas, IS; Lane, JM; Kyle, SD; Vetter, C; Morrison, CL; Jones, SE; Wood, AR; Frayling, TM; Wright, AK; Carr, MJ; Anderson, SG; Emsley, RA; Ray, DW; Weedon, MN; Saxena, R; Rutter, MK; Lawlor, DA |
| Publisher Information: |
Nature Research |
| Publication Year: |
2024 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Self-reported shorter/longer sleep duration, insomnia, and evening preference are associated with hyperglycaemia in observational analyses, with similar observations in small studies using accelerometer-derived sleep traits. Mendelian randomization (MR) studies support an effect of self-reported insomnia, but not others, on glycated haemoglobin (HbA1c). To explore potential effects, we used MR methods to assess effects of accelerometer-derived sleep traits (duration, mid-point least active 5-h, mid-point most active 10-h, sleep fragmentation, and efficiency) on HbA1c/glucose in European adults from the UK Biobank (UKB) (n = 73,797) and the MAGIC consortium (n = 146,806). Cross-trait linkage disequilibrium score regression was applied to determine genetic correlations across accelerometer-derived, self-reported sleep traits, and HbA1c/glucose. We found no causal effect of any accelerometer-derived sleep trait on HbA1c or glucose. Similar MR results for self-reported sleep traits in the UKB sub-sample with accelerometer-derived measures suggested our results were not explained by selection bias. Phenotypic and genetic correlation analyses suggested complex relationships between self-reported and accelerometer-derived traits indicating that they may reflect different types of exposure. These findings suggested accelerometer-derived sleep traits do not affect HbA1c. Accelerometer-derived measures of sleep duration and quality might not simply be ‘objective’ measures of self-reported sleep duration and insomnia, but rather captured different sleep characteristics. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41598-024-58007-9 |
| Availability: |
https://doi.org/10.1038/s41598-024-58007-9; https://ora.ox.ac.uk/objects/uuid:04728388-80e0-449b-9420-862ed6272ebe |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.4ED4E43F |
| Database: |
BASE |