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Chenchen Geng,1,2 Liuyang Yan,1,2 Yunhao Li,1,3 Houcong Li,1,3 Yuxin Ji,1,4 Yuhan Xiao,1,4 Zhifa Wang,1,2 Xiaoqi Chen,1 Changjie Chen,1,4,5 Qingling Yang,1,4,5 Baoding Tang,1,2,6 Wenrui Wang1,2,6 1Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 2School of Life Sciences, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 3School of Basic Courses, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 4Clinical Testing and Diagnose Experimental Center, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 5Department of Biochemistry and Molecular Biology, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 6Anhui Engineering Research Center for Neural Regeneration Technology and Medical New Materials, Bengbu Medical University, Bengbu, Anhui, People’s Republic of ChinaCorrespondence: Wenrui Wang; Baoding Tang, Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu medical university, 2600 Donghai Avenue, Bengbu, Anhui, 233030, People’s Republic of China, Email wenrui-wang1983@163.com; baodtang_16@163.comBackground: Breast cancer is one of the most common cancers among women. Tumor cell proliferation is highly dependent on aerobic glycolysis, so regulating aerobic glycolysis in breast cancer cells is a promising therapeutic strategy. Resveratrol (Res), as a potential new anti-breast cancer drug, has been shown to regulate the glycolysis of cancer cells and inhibit the metastasis and recurrence of breast cancer. The nano drug delivery system can regulate the aerobic glycolysis metabolism by targeting the signaling factors and reaction products of the tumor aerobic glycolysis process to enhance the anti-tumor effect.Methods: A new albumin-modified layered double hydroxide resveratrol dosage form (BSA@LDHs-Res) was synthesized by hydrothermal co-precipitation. Characterization was ... |