| Title: |
Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study |
| Authors: |
Russell, Clark D; Fairfield, Cameron J; Drake, Thomas M; Turtle, Lance; Seaton, R Andrew; Wootton, Dan G; Sigfrid, Louise; Harrison, Ewen M; Docherty, Annemarie B; de Silva, Thushan I; Egan, Conor; Pius, Riinu; Hardwick, Hayley E; Merson, Laura; Girvan, Michelle; Dunning, Jake; Nguyen-Van-Tam, Jonathan S; Openshaw, Peter J M; Baillie, J Kenneth; Semple, Malcolm G; Ho, Antonia; Openshaw, Peter JM; Carson, Gail; Alex, Beatrice; Bach, Benjamin; Barclay, Wendy S; Bogaert, Debby; Chand, Meera; Cooke, Graham S; da Silva Filipe, Ana; Fletcher, Tom; Green, Christopher A; Hiscox, Julian A; Ho, Antonia YW; Horby, Peter W; Ijaz, Samreen; Khoo, Say; Klenerman, Paul; Law, Andrew; Lim, Wei Shen; Mentzer, Alexander J; Meynert, Alison M; Noursadeghi, Mahdad; Moore, Shona C; Palmarini, Massimo; Paxton, William A; Pollakis, Georgios; Price, Nicholas; Rambaut, Andrew; Robertson, David L; Sancho-Shimizu, Vanessa; Scott, Janet T; de Silva, Thushan; Solomon, Tom; Sriskandan, Shiranee; Stuart, David; Summers, Charlotte; Tedder, Richard S; Thomson, Emma C; Thompson, AA Roger; Thwaites, Ryan S; Turtle, Lance CW; Gupta, Rishi K; Palmieri, Carlo; Zambon, Maria; Hardwick, Hayley; Donohue, Chloe; Lyons, Ruth; Griffiths, Fiona; Oosthuyzen, Wilna; Norman, Lisa; Knight, Stephen R; Mclean, Kenneth A; Murphy, Derek; Shaw, Catherine A; Dalton, Jo; Saviciute, Egle; Roberts, Stephanie; Harrison, Janet; Marsh, Laura; Connor, Marie; Halpin, Sophie; Jackson, Clare; Gamble, Carrol; Leeming, Gary; Wham, Murray; Clohisey, Sara; Hendry, Ross; Scott-Brown, James; Greenhalf, William; Shaw, Victoria; McDonald, Sarah E; Keating, Seán; Ahmed, Katie A.; Armstrong, Jane A; Ashworth, Milton; Asiimwe, Innocent G; Bakshi, Siddharth; Barlow, Samantha L; Booth, Laura; Brennan, Benjamin; Bullock, Katie; Catterall, Benjamin WA; Clark, Jordan J; Clarke, Emily A; Cole, Sarah; Cooper, Louise; Cox, Helen; Davis, Christopher; Dincarslan, Oslem; Dunn, Chris; Dyer, Philip; Elliott, Angela; Evans, Anthony; Finch, Lorna; Fisher, Lewis WS; Foster, Terry; Garcia-Dorival, Isabel; Gunning, Philip; Hartley, Catherine; Jensen, Rebecca L; Jones, Christopher B; Jones, Trevor R; Khandaker, Shadia; King, Katharine; Kiy, Robyn T.; Koukorava, Chrysa; Lake, Annette; Lant, Suzannah; Latawiec, Diane; Lavelle-Langham, Lara; Lefteri, Daniella; Lett, Lauren; Livoti, Lucia A; Mancini, Maria; McDonald, Sarah; McEvoy, Laurence; McLauchlan, John; Metelmann, Soeren; Miah, Nahida S; Middleton, Joanna; Mitchell, Joyce; Murphy, Ellen G; Penrice-Randal, Rebekah; Pilgrim, Jack; Prince, Tessa; Reynolds, Will; Ridley, P. Matthew; Sales, Debby; Shaw, Victoria E; Shears, Rebecca K; Small, Benjamin; Subramaniam, Krishanthi S; Szemiel, Agnieska; Taggart, Aislynn; Tanianis-Hughes, Jolanta; Thomas, Jordan; Trochu, Erwan; van Tonder, Libby; Wilcock, Eve; Zhang, J. Eunice; Flaherty, Lisa; Maziere, Nicole; Cass, Emily; Doce Carracedo, Alejandra; Carlucci, Nicola; Holmes, Anthony; Massey, Hannah; Murphy, Lee; Wrobel, Nicola; McCafferty, Sarah; Morrice, Kirstie; MacLean, Alan; Adeniji, Kayode; Agranoff, Daniel; Agwuh, Ken; Ail, Dhiraj; Aldera, Erin L.; Alegria, Ana; Angus, Brian; Ashish, Abdul; Atkinson, Dougal; Bari, Shahedal; Barlow, Gavin; Barnass, Stella; Barrett, Nicholas; Bassford, Christopher; Basude, Sneha; Baxter, David; Beadsworth, Michael; Bernatoniene, Jolanta; Berridge, John; Best, Nicola; Bothma, Pieter; Chadwick, David; Brittain-Long, Robin; Bulteel, Naomi; Burden, Tom; Burtenshaw, Andrew; Caruth, Vikki; Chambler, Duncan; Chee, Nigel; Child, Jenny; Chukkambotla, Srikanth; Clark, Tom; Collini, Paul; Cosgrove, Catherine; Cupitt, Jason; Cutino-Moguel, Maria-Teresa; Dark, Paul; Dawson, Chris; Dervisevic, Samir; Donnison, Phil; Douthwaite, Sam; DuRand, Ingrid; Dushianthan, Ahilanadan; Dyer, Tristan; Evans, Cariad; Eziefula, Chi; Fegan, Chrisopher; Finn, Adam; Fullerton, Duncan; Garg, Sanjeev; Garg, Atul; Gkrania-Klotsas, Effrossyni; Godden, Jo; Goldsmith, Arthur; Graham, Clive; Hardy, Elaine; Hartshorn, Stuart; Harvey, Daniel; Havalda, Peter; Hawcutt, Daniel B; Hobrok, Maria; Hodgson, Luke; Hormis, Anil; Jacobs, Michael; Jain, Susan; Jennings, Paul; Kaliappan, Agilan; Kasipandian, Vidya; Kegg, Stephen; Kelsey, Michael; Kendall, Jason; Kerrison, Caroline; Kerslake, Ian; Koch, Oliver; Koduri, Gouri; Koshy, George; Laha, Shondipon; Laird, Steven; Larkin, Susan; Leiner, Tamas; Lillie, Patrick; Limb, James; Linnett, Vanessa; Little, Jeff; Lyttle, Mark; MacMahon, Michael; MacNaughton, Emily; Mankregod, Ravish; Masson, Huw; Matovu, Elijah; McCullough, Katherine; McEwen, Ruth; Meda, Manjula; Mills, Gary; Minton, Jane; Mirfenderesky, Mariyam; Mohandas, Kavya; Mok, Quen; Moon, James; Moore, Elinoor; Morgan, Patrick; Morris, Craig; Mortimore, Katherine; Moses, Samuel; Mpenge, Mbiye; Mulla, Rohinton; Murphy, Michael; Nagel, Megan; Nagarajan, Thapas; Nelson, Mark; O'Shea, Matthew K.; Otahal, Igor; Ostermann, Marlies; Pais, Mark; Panchatsharam, Selva; Papakonstantino, Danai; Paraiso, Hassan; Patel, Brij; Pattison, Natalie; Pepperell, Justin; Peters, Mark; Phull, Mandeep; Pintus, Stefania; Singh Pooni, Jagtur; Post, Frank; Price, David; Prout, Rachel; Rae, Nikolas; Reschreiter, Henrik; Reynolds, Tim; Richardson, Neil; Roberts, Mark; Roberts, Devender; Rose, Alistair; Rousseau, Guy; Ryan, Brendan; Saluja, Taranprit; Shah, Aarti; Shanmuga, Prad; Sharma, Anil; Shawcross, Anna; Sizer, Jeremy; Shankar-Hari, Manu; Smith, Richard; Snelson, Catherine; Spittle, Nick; Staines, Nikki; Stambach, Tom; Stewart, Richard; Subudhi, Pradeep; Szakmany, Tamas; Tatham, Kate; Thomas, Jo; Thompson, Chris; Thompson, Robert; Tridente, Ascanio; Tupper-Carey, Darell; Twagira, Mary; Ustianowski, Andrew; Vallotton, Nick; Vincent-Smith, Lisa; Visuvanathan, Shico; Vuylsteke, Alan; Waddy, Sam; Wake, Rachel; Walden, Andrew; Welters, Ingeborg; Whitehouse, Tony; Whittaker, Paul; Whittington, Ashley; Papineni, Padmasayee; Wijesinghe, Meme; Williams, Martin; Wilson, Lawrence; Sarah, Sarah; Winchester, Stephen; Wiselka, Martin; Wolverson, Adam; Wootton, Daniel G; Workman, Andrew; Yates, Bryan; Young, Peter |
| Publisher Information: |
Elsevier |
| Publication Year: |
2021 |
| Collection: |
University of Nottingham: Repository@Nottingham |
| Description: |
BackgroundMicrobiological characterisation of co-infections and secondary infections in patients with COVID-19 is lacking, and antimicrobial use is high. We aimed to describe microbiologically confirmed co-infections and secondary infections, and antimicrobial use, in patients admitted to hospital with COVID-19.MethodsThe International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) WHO Clinical Characterisation Protocol UK (CCP-UK) study is an ongoing, prospective cohort study recruiting inpatients from 260 hospitals in England, Scotland, and Wales, conducted by the ISARIC Coronavirus Clinical Characterisation Consortium. Patients with a confirmed or clinician-defined high likelihood of SARS-CoV-2 infection were eligible for inclusion in the ISARIC WHO CCP-UK study. For this specific study, we excluded patients with a recorded negative SARS-CoV-2 test result and those without a recorded outcome at 28 days after admission. Demographic, clinical, laboratory, therapeutic, and outcome data were collected using a prespecified case report form. Organisms considered clinically insignificant were excluded.FindingsWe analysed data from 48 902 patients admitted to hospital between Feb 6 and June 8, 2020. The median patient age was 74 years (IQR 59–84) and 20 786 (42·6%) of 48 765 patients were female. Microbiological investigations were recorded for 8649 (17·7%) of 48 902 patients, with clinically significant COVID-19-related respiratory or bloodstream culture results recorded for 1107 patients. 762 (70·6%) of 1080 infections were secondary, occurring more than 2 days after hospital admission. Staphylococcus aureus and Haemophilus influenzae were the most common pathogens causing respiratory co-infections (diagnosed ≤2 days after admission), with Enterobacteriaceae and S aureus most common in secondary respiratory infections. Bloodstream infections were most frequently caused by Escherichia coli and S aureus. Among patients with available data, 13 390 (37·0%) of 36 145 had received antimicrobials in ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://nottingham-repository.worktribe.com/output/5755939; The Lancet Microbe; Volume 2; Issue 8; Pagination e354-e365 |
| DOI: |
10.1016/s2666-5247%2821%2900090-2 |
| DOI: |
10.1016/s2666-5247(21)00090-2 |
| Availability: |
https://doi.org/10.1016/s2666-5247%2821%2900090-2; https://nottingham-repository.worktribe.com/file/5755939/1/PIIS2666524721000902; https://nottingham-repository.worktribe.com/output/5755939; https://doi.org/10.1016/s2666-5247(21)00090-2 |
| Rights: |
openAccess ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.4EFF90A7 |
| Database: |
BASE |