| Title: |
Neuropsychological Impairments and Their Cognitive Architecture in Mild Cognitive Impairment (MCI) with Lewy Bodies and MCI-Alzheimer’s Disease |
| Authors: |
Ciafone, Joanna; Thomas, Alan; Durcan, Rory; Donaghy, Paul C; Hamilton, Calum A; Lawley, Sarah; Roberts, Gemma; Colloby, Sean; Firbank, Michael J; Allan, Louise; Petrides, George; Taylor, John-Paul; O’Brien, John T; Gallagher, Peter |
| Source: |
Journal of the International Neuropsychological Society ; volume 28, issue 9, page 963-973 ; ISSN 1355-6177 1469-7661 |
| Publisher Information: |
Cambridge University Press (CUP) |
| Publication Year: |
2021 |
| Description: |
Objective: The present study aimed to clarify the neuropsychological profile of the emergent diagnostic category of Mild Cognitive Impairment with Lewy bodies (MCI-LB) and determine whether domain-specific impairments such as in memory were related to deficits in domain-general cognitive processes (executive function or processing speed). Method: Patients ( n = 83) and healthy age- and sex-matched controls ( n = 34) underwent clinical and imaging assessments. Probable MCI-LB ( n = 44) and MCI-Alzheimer’s disease (AD) ( n = 39) were diagnosed following National Institute on Aging-Alzheimer’s Association (NIA-AA) and dementia with Lewy bodies (DLB) consortium criteria. Neuropsychological measures included cognitive and psychomotor speed, executive function, working memory, and verbal and visuospatial recall. Results: MCI-LB scored significantly lower than MCI-AD on processing speed [Trail Making Test B: p = .03, g = .45; Digit Symbol Substitution Test (DSST): p = .04, g = .47; DSST Error Check: p < .001, g=.68] and executive function [Trail Making Test Ratio (A/B): p=.04, g=.52] tasks. MCI-AD performed worse than MCI-LB on memory tasks, specifically visuospatial (Modified Taylor Complex Figure: p=.01, g=.46) and verbal (Rey Auditory Verbal Learning Test: p=.04, g=.42) delayed recall measures. Stepwise discriminant analysis correctly classified the subtype in 65.1% of MCI patients (72.7% specificity, 56.4% sensitivity). Processing speed accounted for more group-associated variance in visuospatial and verbal memory in both MCI subtypes than executive function, while no significant relationships between measures were observed in controls (all p s > .05) Conclusions: MCI-LB was characterized by executive dysfunction and slowed processing speed but did not show the visuospatial dysfunction expected, while MCI-AD displayed an amnestic profile. However, there was considerable neuropsychological profile overlap and processing speed mediated performance in both MCI subtypes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1017/s1355617721001181 |
| Availability: |
https://doi.org/10.1017/s1355617721001181; https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S1355617721001181 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.4F1307B2 |
| Database: |
BASE |