| Title: |
Healthy Life-Year Costs of Treatment Speed From Arrival to Endovascular Thrombectomy in Patients With Ischemic Stroke |
| Authors: |
Almekhlafi, Mohammed, A; Goyal, Mayank; Dippel, Diederik, W J; Majoie, Charles, B L M; Campbell, Bruce, C V; Muir, Keith, W; Demchuk, Andrew, M; Bracard, Serge; Guillemin, Francis; Jovin, Tudor, G; Mitchell, Peter, J; White, Philip; Hill, Michael, D; Brown, Scott; Saver, Jeffrey, L; Berkhemer, Olvert, A; Fransen, Puck, S S; Beumer, Debbie; van den Berg, Lucie, A; Lingsma, Hester, F; Yoo, Albert, J; Schonewille, Wouter, J; Vos, Jan, Albert; Nederkoorn, Paul, J; Wermer, Marieke, J H; van Walderveen, Marianne, a A; Staals, Julie; Hofmeijer, Jeannette; van Oostayen, Jacques, A; Lycklama À Nijeholt, Geert, J; Boiten, Jelis; Brouwer, Patrick, A; Emmer, Bart, J; de Bruijn, Sebastiaan, F; van Dijk, Lukas, C; Kappelle, L, Jaap; Lo, Rob, H; van Dijk, Ewoud, J; de Vries, Joost; de Kort, Paul, L M; van Rooij, Willem, Jan J; van den Berg, Jan, S P; van Hasselt, Boudewijn, a a M; Aerden, Leo, a M; Dallinga, René, J; Visser, Marieke, C; Bot, Joseph, C J; Vroomen, Patrick, C; Eshghi, Omid; Schreuder, Tobien, H C M L; Heijboer, Roel, J J; Keizer, Koos; Tielbeek, Alexander, V; den Hertog, Heleen, M; Gerrits, Dick, G; van den Berg-Vos, Renske, M; Karas, Giorgos, B; Steyerberg, Ewout, W; Flach, H, Zwenneke; Marquering, Henk, A; Sprengers, Marieke, E S; Jenniskens, Sjoerd, F M; Beenen, Ludo, F M; van den Berg, René; Koudstaal, Peter, J; van Zwam, Wim, H; Roos, Yvo, B W E M; van Der Lugt, Aad; van Oostenbrugge, Robert, J; Menon, Bijoy, K; Eesa, Muneer; Rempel, Jeremy, L; Thornton, John; Roy, Daniel; Willinsky, Robert, A; Sapkota, Biggya, L; Dowlatshahi, Dar; Frei, Donald, F; Kamal, Noreen, R; Montanera, Walter, J; Poppe, Alexandre, y; Ryckborst, Karla, J; Silver, Frank, L; Shuaib, Ashfaq; Tampieri, Donatella; Williams, David; Bang, Oh, Young; Baxter, Blaise, W; Burns, Paul, A; Choe, Hana; Heo, Ji-Hoe; Holmstedt, Christine, A; Jankowitz, Brian; Kelly, Michael; Linares, Guillermo; Mandzia, Jennifer, L; Shankar, Jai; Sohn, Sung-Il; Swartz, Richard, H; Coutts, Shelagh, B; Smith, Eric, E; Morrish, William, F; Weill, Alain; Subramaniam, Suresh; Mitha, Alim, P; Wong, John, H; Lowerison, Mark, W; Sajobi, Tolulope, T; Bonafe, Alain; Diener, Hans, C; Levy, Elad, I; Pereira, Vitor, M; Albers, Gregory, W; Cognard, Christophe; Cohen, David, J; Hacke, Werner; Jansen, Olav; Mattle, Heinrich, P; Nogueira, Raul, G; Siddiqui, Adnan, H; Yavagal, Dileep, R; Devlin, Thomas, G; Lopes, Demetrius, K; Reddy, Vivek, K; Du Mesnil de Rochemont, Richard; Singer, Oliver, C; Jahan, Reza; Kleinig, Timothy, J; Dewey, Helen, M; Churilov, Leonid; Yassi, Nawaf; Yan, Bernard; Dowling, Richard, J; Parsons, Mark, W; Oxley, Thomas, J; Wu, Teddy, y; Brooks, Mark; Simpson, Marion, A; Miteff, Ferdinand; Levi, Christopher, R; Krause, Martin; Harrington, Timothy, J; Faulder, Kenneth, C; Steinfort, Brendan, S; Priglinger, Miriam; Ang, Timothy; Scroop, Rebecca; Barber, Philip, A; Mcguinness, Ben; Wijeratne, Tissa; Phan, Thanh, G; Chong, Winston; Chandra, Ronil, V; Bladin, Christopher, F; Badve, Monica; Rice, Henry; de Villiers, Laetitia; Ma, Henry; Desmond, Patricia, M; Donnan, Geoffrey, A; Davis, Stephen, M; Chamorro, Angel; Cobo, Erik; de Miquel, María, A; Molina, Carlos, A; Rovira, Alex; San Román, Luis; Serena, Joaquín; Abilleira, Sonia; Ribó, Marc; Millán, Mònica; Urra, Xabier; Cardona, Pere; López-Cancio, Elena; Tomasello, Alejandro; Castaño, Carlos; Blasco, Jordi; Aja, Lucía; Dorado, Laura; Quesada, Helena; Rubiera, Marta; Hernandez-Pérez, María; von Kummer, Rüdiger; Gallofré, Miquel; Dávalos, Antoni; Ford, Gary, A; Messow, Claudia-Martina; Ford, Ian; Murray, Alicia; Clifton, Andrew; Brown, Martin, M; Madigan, Jeremy; Lenthall, Rob; Robertson, Fergus; Dixit, Anand; Cloud, Geoffrey, C; Wardlaw, Joanna; Freeman, Janet; Ducrocq, Xavier; Mas, Jean, Louis; Soudant, Marc; Oppenheim, Catherine; Moulin, Thierry |
| Contributors: |
University of Calgary; Erasmus University Medical Center Rotterdam (Erasmus MC); Department of Radiology and Nuclear Medicine Amsterdam; VU University Medical Center Amsterdam; University of Melbourne; University of Glasgow; Imagerie Adaptative Diagnostique et Interventionnelle (IADI); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL); Département de neuroradiologie diagnostique et thérapeutique CHRU Nancy; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy); Centre d'investigation clinique Nancy (CIC); Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL); The Royal Melbourne Hospital; Newcastle University Newcastle; Altair Development; David Geffen School of Medicine Los Angeles; University of California Los Angeles (UCLA); University of California (UC)-University of California (UC) |
| Source: |
ISSN: 2168-6149. |
| Publisher Information: |
CCSD; American Medical Association |
| Publication Year: |
2021 |
| Collection: |
Université de Lorraine: HAL |
| Subject Terms: |
MESH: Endovascular Procedures / psychology; MESH: Endovascular Procedures / trends; MESH: Time-to-Treatment / trends; MESH: Treatment Outcome; MESH: Humans; MESH: Ischemic Stroke / diagnosis; MESH: Ischemic Stroke / psychology; MESH: Ischemic Stroke / therapy; MESH: Quality of Life* / psychology; MESH: Randomized Controlled Trials as Topic / methods; MESH: Thrombectomy / psychology; MESH: Thrombectomy / trends; [INFO.INFO-IM]Computer Science [cs]/Medical Imaging; [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; Importance: The benefits of endovascular thrombectomy (EVT) are time dependent. Prior studies may have underestimated the time-benefit association because time of onset is imprecisely known. Objective: To assess the lifetime outcomes associated with speed of endovascular thrombectomy in patients with acute ischemic stroke due to large-vessel occlusion (LVO). Data sources: PubMed was searched for randomized clinical trials of stent retriever thrombectomy devices vs medical therapy in patients with anterior circulation LVO within 12 hours of last known well time, and for which a peer-reviewed, complete primary results article was published by August 1, 2020. Study selection: All randomized clinical trials of stent retriever thrombectomy devices vs medical therapy in patients with anterior circulation LVO within 12 hours of last known well time were included. Data extraction/synthesis: Patient-level data regarding presenting clinical and imaging features and functional outcomes were pooled from the 7 retrieved randomized clinical trials of stent retriever thrombectomy devices (entirely or predominantly) vs medical therapy. All 7 identified trials published in a peer-reviewed journal (by August 1, 2020) contributed data. Detailed time metrics were collected including last known well-to-door (LKWTD) time; last known well/onset-to-puncture (LKWTP) time; last known well-to-reperfusion (LKWR) time; door-to-puncture (DTP) time; and door-to-reperfusion (DTR) time. Main outcomes and measures: Change in healthy life-years measured as disability-adjusted life-years (DALYs). DALYs were calculated as the sum of years of life lost (YLL) owing to premature mortality and years of healthy life lost because of disability (YLD). Disability weights were assigned using the utility-weighted modified Rankin Scale. Age-specific life expectancies without stroke were calculated from 2017 US National Vital Statistics. Results: Among the 781 EVT-treated patients, 406 (52.0%) were early-treated (LKWTP ≤4 hours) and ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33938914; PUBMED: 33938914; PUBMEDCENTRAL: PMC8094030 |
| DOI: |
10.1001/jamaneurol.2021.1055 |
| Availability: |
https://hal.univ-lorraine.fr/hal-03220460; https://hal.univ-lorraine.fr/hal-03220460v1/document; https://hal.univ-lorraine.fr/hal-03220460v1/file/jamaneurology_almekhlafi_2021_oi_210020_1619662792.50218.pdf; https://doi.org/10.1001/jamaneurol.2021.1055 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.4F435E4A |
| Database: |
BASE |