| Title: |
The medical management of acute respiratory distress syndrome. |
| Authors: |
Morris, Idunn S; Amato, Marcelo; Baedorf Kassis, Elias; Bellani, Giacomo; Calfee, Carolyn S; Heunks, Leo; Hodgson, Carol; Nair, Priya; Serpa Neto, Ary; Sahetya, Sarina; Summers, Charlotte; Telias, Irene; Yoshida, Takeshi; Slutsky, Arthur S; Ferguson, Niall D |
| Publisher Information: |
Springer Nature; Department of Medicine; //doi.org/10.1007/s00134-025-08251-y |
| Publication Year: |
2026 |
| Collection: |
Apollo - University of Cambridge Repository |
| Subject Terms: |
Acute hypoxemic respiratory failure; Mechanical ventilation; Positive end-expiratory pressure; Ventilator-induced lung injury; Humans; Respiratory Distress Syndrome; Respiration; Artificial |
| Description: |
Despite advancements in bedside monitoring and paradigm shifts in standard ventilatory practice, mortality from acute respiratory distress syndrome (ARDS) remains high. The recent Global ARDS definition adopts a more pragmatic approach enabling earlier identification across a broader patient spectrum, independent of the interventions being administered. Meanwhile, our understanding of managing this heterogeneous syndrome has shifted towards defining precise subgroups with shared therapeutic targets. Physiological, biological, and radiological phenotypes may modify the response to interventions previously showing indeterminate benefit, making them potentially central to future personalised ARDS management. This narrative review summarises core evidence for the medical and ventilatory management of ARDS, explores emerging concepts, and offers clinicians a framework for current best practice and a roadmap for possible future directions. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://www.repository.cam.ac.uk/handle/1810/393546; https://doi.org/10.17863/CAM.123845 |
| DOI: |
10.17863/CAM.123845 |
| Availability: |
https://www.repository.cam.ac.uk/handle/1810/393546; https://doi.org/10.17863/CAM.123845 |
| Rights: |
Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.4F58D62C |
| Database: |
BASE |