Genome-wide association study identifies 48 common genetic variants associated with handedness
| Title: | Genome-wide association study identifies 48 common genetic variants associated with handedness |
|---|---|
| Authors: | Cuellar-Partida, G; Tung, JY; Eriksson, N; Albrecht, E; Aliev, F; Andreassen, OA; Barroso, I; Beckmann, JS; Boks, M P; Boomsma, DI; Boyd, HA; Breteler, Monique; Campbell, H; Chasman, DI; Cherkas, LF; Davies, G; de Geus, EJCN; Deary, IJ; Deloukas, P; Dick, DM; Duffy, DL; Eriksson, JG; Esko, T; Feenstra, B; Geller, F; Gieger, C; Giegling, I; Gordon, SD; Han, J; Hansen, TF; Hartmann, AM; Hayward, C; Heikkilä, K; Hicks, AA; Hirschhorn, JN; Hottenga, JJ; Huffman, JE; Hwang, LD; Ikram, Arfan; Kaprio, J; Kemp, JP; Khaw, KTH; Klopp, N; Konte, B; Kutalik, Z; Lahti, J; Li, X; Loos, RJ; Luciano, M; Magnusson, SH; Mangino, M; Marques-Vidal, P; Martin, NG; McArdle, WL; McCarthy, MI; Medina Gomez, Maria; Melbye, M; Melville, SA; Metspalu, A; Milani, L; Mooser, V; Nelis, M; Nyholt, DR; O’Connell, KS; Ophoff, Roel; Palmer, C; Palotie, A; Palviainen, T; Pare, G; Paternoster, L; Peltonen, L; Penninx, BWJH; Polasek, O; Pramstaller, PP; Prokopenko, I; Raikkonen, K; Ripatti, S; Rivadeneira, Fernando; Rudan, I; Rujescu, D; Smit, JH; Smith, GD; Smoller, JW; Soranzo, N; Spector, TD; Pourcain, BS; Starr, JM; Stefánsson, H; Steinberg, S; Teder-Laving, M; Thorleifsson, G; Stefánsson, K; Timpson, NJ; Uitterlinden, André; Duijn, Cornelia; van Rooij, FJA; Vink, JM; Vollenweider, P; Vuoksimaa, E; Waeber, G; Wareham, NJ; Warrington, N; Waterworth, D; Werge, T; Wichmann, HE; Widen, E; Willemsen, G; Wright, AF; Wright, MJ; Xu, M; Zhao, JH; Kraft, P; Hinds, DA; Lindgren, CM; Mägi, R; Neale, BM; Evans, DM; Medland, SE |
| Source: | Cuellar-Partida, G, Tung, JY, Eriksson, N, Albrecht, E, Aliev, F, Andreassen, OA, Barroso, I, Beckmann, JS, Boks, M P, Boomsma, DI, Boyd, HA, Breteler, M, Campbell, H, Chasman, DI, Cherkas, LF, Davies, G, de Geus, EJCN, Deary, IJ, Deloukas, P, Dick, DM, Duffy, DL, Eriksson, JG, Esko, T, Feenstra, B, Geller, F, Gieger, C, Giegling, I, Gordon, SD, Han, J, Hansen, TF, Hartmann, AM, Hayward, C, Heikkilä, K, Hicks, AA, Hirschhorn, JN, Hottenga, JJ, Huffman, JE, Hwang, LD, Ikram, A, Kaprio, J, Kemp, JP, Khaw, KTH, Klopp, N, Konte, B, Kutalik, Z, Lahti, J, Li, X, Loos, RJ, Luciano, .... |
| Publication Year: | 2021 |
| Subject Terms: | /dk/atira/pure/keywords/researchprograms/AFL001000/EMCOR01; name=EMC OR-01 |
| Description: | Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10 −8 ) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (r G = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| ISSN: | 2397-3374 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32989287; info:eu-repo/semantics/altIdentifier/wos/000573450500001; info:eu-repo/semantics/altIdentifier/pissn/2397-3374; info:eu-repo/semantics/altIdentifier/eissn/2397-3374 |
| DOI: | 10.1038/s41562-020-00956-y |
| Availability: | https://pure.eur.nl/en/publications/f6d7ad83-b9d1-4cc1-b81b-5d34ba8f141d; https://doi.org/10.1038/s41562-020-00956-y; https://www.scopus.com/pages/publications/85091609696; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116623/ |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.4F74071D |
| Database: | BASE |