| Title: |
Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia |
| Authors: |
Villafuerte, David; Aliberti, Stefano; Soni, Nilam J.; Faverio, Paola; Marcos, Pedro J.; Wunderink, Richard G.; Rodriguez, Alejandro; Sibila, Oriol; Sanz, Francisco; Martin‐Loeches, Ignacio; Menzella, Francesco; Reyes, Luis F.; Jankovic, Mateja; Spielmanns, Marc; Restrepo, Marcos I.; Aruj, Patricia Karina; Attorri, Silvia; Barimboim, Enrique; Caeiro, Juan Pablo; Garzón, María I.; Cambursano, Victor Hugo; Ceccato, Adrian; Chertcoff, Julio; Cordon Díaz, Ariel; de Vedia, Lautaro; Ganaha, Maria Cristina; Lambert, Sandra; Lopardo, Gustavo; Luna, Carlos M.; Malberti, Alessio Gerardo; Morcillo, Nora; Tartara, Silvina; Pensotti, Claudia; Pereyra, Betiana; Scapellato, Pablo Gustavo; Stagnaro, Juan Pablo; Shah, Sonali; Lötsch, Felix; Thalhammer, Florian; Anseeuw, Kurt; Francois, Camille A.; Van Braeckel, Eva; Vincent, Jean Louis; Djimon, Marcel Zannou; Nouér, Simone Aranha; Chipev, Peter; Encheva, Milena; Miteva, Darina; Petkova, Diana; Balkissou, Adamou Dodo; Yone, Eric Walter Pefura; Ngahane, Bertrand Hugo Mbatchou; Shen, Ning; Xu, Jin-fu; Rico, Carlos Andres Bustamante; Buitrago, Ricardo; Paternina, Fernando Jose Pereira; Ntumba, Jean-Marie Kayembe; Carevic, Vesna Vladic; Jakopovic, Marko; Matkovic, Zinka; Mitrecic, Ivan; Jacobsson, Marie-Laure Bouchy; Christensen, Anette Bro; Heitmann Bødtger, Uffe Christian; Meyer, Christian Niels; Jensen, Andreas Vestergaard; El-Said Abd El-Wahhab, Ibrahim; Morsy, Nesreen Elsayed; Shafiek, Hanaa; Sobh, Eman; Abdulsemed, Kedir Abdella; Bertrand, Fabrice; Brun‐Buisson, Christian; Montmollin, Etienne de; Fartoukh, Muriel; Messika, Jonathan; Tattevin, Pierre; Khoury, Abdo; Ebruke, Bernard; Dreher, Michael; Kolditz, Martin; Meisinger, Matthias; Pletz, Mathias W.; Hagel, Stefan; Rupp, Jan; Schaberg, Tom; Creutz, Petra; Suttorp, Norton; Siaw-Lartey, Beatrice; Dimakou, Katerina; Papapetrou, Dimosthenis; Tsigou, Evdoxia; Ampazis, Dimitrios; Kaimakamis, Evangelos; Bhatia, Mohit; Dhar, Raja; D'Souza, George; Garg, Rajiv; Koul, Parvaiz A; Mahesh, PA; Jayaraj, BS; Narayan, Kiran Vishnu; Udnur, Hirennappa B; Krishnamurthy, Shashi Bhaskara; Kant, Surya; Swarnakar, Rajesh; Limaye, Sneha; Salvi, Sundeep; Golshani, Keihan; Keatings, Vera M; Martin-Loeches, Ignacio; Maor, Yasmin; Strahilevitz, Jacob; Battaglia, Salvatore; Carrabba, Maria; Ceriana, Piero; Confalonieri, Marco; Monforte, Antonella d'Arminio; Prato, Bruno Del; Rosa, Marino De; Fantini, Riccardo; Fiorentino, Giuseppe; Gammino, Maria Antonia; Milani, Giuseppe; Nava, Stefano; Palmiero, Gerardo; Petrino, Roberta; Gabrielli, Barbra; Rossi, Paolo; Sorino, Claudio; Steinhilber, Gundi; Zanforlin, Alessandro; Franzetti, Fabio; Carone, Mauro; Patella, Vincenzo; Scarlata, Simone; Comel, Andrea; Kurahashi, Kiyoyasu; Bacha, Zeina Aoun; Ugalde, Daniel Barajas; Zuñiga, Omar Ceballos; Villegas, José F; Medenica, Milic; van de Garde, E.M.W.; Mihsra, Deebya Raj; Shrestha, Poojan; Ridgeon, Elliott; Awokola, Babatunde Ishola; Nwankwo, Ogonna N.O.; Olufunlola, Adefuye Bolanle; Olumide, Segaolu; Ukwaja, Kingsley N.; Irfan, Muhammad; Minarowski, Lukasz; Szymon, Skoczyński; Froes, Felipe; Leuschner, Pedro; Meireles, Mariana; Ravara, Sofia B; Brocovschii, Victoria; Ion, Chesov; Rusu, Doina; Toma, Cristina; Chirita, Daniela; Dorobat, Carmen Mihaela; Birkun, Alexei; Kaluzhenina, Anna; Almotairi, Abdullah; Bukhary, Zakeya Abdulbaqi Ali; Edathodu, Jameela; Fathy, Amal; Enani, Abdullah Mushira Abdulaziz; Mohamed, Nazik Eltayeb; Memon, Jawed Ulhadi; Bella, Abdelhaleem; Bogdanović, Nada; Milenkovic, Branislava; Pesut, Dragica; Borderìas, Luis; Garcia, Noel Manuel Bordon; Cabello Alarcón, Hugo; Cilloniz, Catia; Torres, Antoni; Diaz-Brito, Vicens; Casas, Xavier; González, Alicia Encabo; Fernández‐Almira, Maria Luisa; Gallego, Miguel; Gaspar‐García, Inmaculada; Castillo, Juan González del; Victoria, Patricia Javaloyes; Laserna Martínez, Elena; Molina, Rosa Malo de; Marcos, Pedro J; Menéndez, Rosario; Pando‐Sandoval, Ana; Aymerich, Cristina Prat; Rello, Jordi; Moyano, Silvia; Rodrigo‐Troyano, Ana; Solé‐Violán, Jordi; Uranga, Ane; van Boven, Job FM; Torra, Ester Vendrell; Pujol, Jordi Almirall; Feldman, Charles; Yum, Ho Kee; Fiogbe, Arnauld Attannon; Yangui, Ferdaous; Bilaceroglu, Semra; Dalar, Levent; Yilmaz, Ufuk; Bogomolov, Artemii; Elahi, Naheed; Dhasmana, Devesh J; Feneley, Andrew; Hancock, Carole; Hill, Adam T; Rudran, Banu; Ruiz‐Buitrago, Silvia; Campbell, Marion; Whitaker, Paul; Youzguin, Alexander; Singanayagam, Anika; Allen, Karen S; Brito, Veronica; Dietz, Jessica; Dysart, Claire E.; Kellie, Susan M.; Franco‐Sadud, Ricardo A; Meier, Garnet; Gaga, Mina; Holland, Thomas L.; Bergin, Stephen P.; Kheir, Fayez; Landmeier, Mark; Lois, Manuel; Nair, Girish B; Patel, Hemali; Reyes, Katherine; Rodriguez‐Cintron, William; Saito, Shigeki; Noda, Julio; Hinojosa, Cecilia I.; Levine, Stephanie M.; Angel, Luis F.; Anzueto, Antonio; Whitlow, K. Scott; Hipskind, John; Sukhija, Kunal; Totten, Vicken; Shah, Ray D.; Mateyo, Kondwelani John; Noriega, Lorena; Alvarado, Ezequiel; Aman, Mohamed; Labra, Lucía; GLIMP Investigators, missing |
| Source: |
RESPIROLOGY ; ISSN: 1323-7799 ; ISSN: 1440-1843 |
| Publication Year: |
2019 |
| Collection: |
Ghent University Academic Bibliography |
| Subject Terms: |
Medicine and Health Sciences; Pulmonary and Respiratory Medicine; ANTIBIOTIC-RESISTANT PATHOGENS; INFECTIOUS-DISEASES-SOCIETY; GUIDELINES; AERUGINOSA; MANAGEMENT; ADULTS; community-acquired pneumonia; Enterobacteriaceae; multidrug-resistance; prevalence; risk factors |
| Description: |
Background and objective Enterobacteriaceae (EB) spp. family is known to include potentially multidrug-resistant (MDR) microorganisms, and remains as an important cause of community-acquired pneumonia (CAP) associated with high mortality. The aim of this study was to determine the prevalence and specific risk factors associated with EB and MDR-EB in a cohort of hospitalized adults with CAP. Methods We performed a multinational, point-prevalence study of adult patients hospitalized with CAP. MDR-EB was defined when >= 3 antimicrobial classes were identified as non-susceptible. Risk factors assessment was also performed for patients with EB and MDR-EB infection. Results Of the 3193 patients enrolled with CAP, 197 (6%) had a positive culture with EB. Fifty-one percent (n = 100) of EB were resistant to at least one antibiotic and 19% (n = 38) had MDR-EB. The most commonly EB identified were Klebsiella pneumoniae (n = 111, 56%) and Escherichia coli (n = 56, 28%). The risk factors that were independently associated with EB CAP were male gender, severe CAP, underweight (body mass index (BMI) < 18.5) and prior extended-spectrum beta-lactamase (ESBL) infection. Additionally, prior ESBL infection, being underweight, cardiovascular diseases and hospitalization in the last 12 months were independently associated with MDR-EB CAP. Conclusion This study of adults hospitalized with CAP found a prevalence of EB of 6% and MDR-EB of 1.2%, respectively. The presence of specific risk factors, such as prior ESBL infection and being underweight, should raise the clinical suspicion for EB and MDR-EB in patients hospitalized with CAP. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://biblio.ugent.be/publication/8641985; https://doi.org/10.1111/resp.13663; https://biblio.ugent.be/publication/8641985/file/8667545 |
| DOI: |
10.1111/resp.13663 |
| Availability: |
https://biblio.ugent.be/publication/8641985; https://hdl.handle.net/1854/LU-8641985; https://doi.org/10.1111/resp.13663; https://biblio.ugent.be/publication/8641985/file/8667545 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| Accession Number: |
edsbas.4F8E79F7 |
| Database: |
BASE |