| Title: |
Comparison of inter- and intra-cycle variability of anti-Mullerian hormone and antral follicle counts |
| Authors: |
van Disseldorp, J; Lambalk, CB; Kwee, J; Looman, Caspar; Eijkemans, Rene; Fauser, BC; Broekmans, FJ |
| Source: |
van Disseldorp, J, Lambalk, CB, Kwee, J, Looman, C, Eijkemans, R, Fauser, BC & Broekmans, FJ 2010, 'Comparison of inter- and intra-cycle variability of anti-Mullerian hormone and antral follicle counts', Human Reproduction, vol. 25, no. 1, pp. 221-227. https://doi.org/10.1093/humrep/dep366 |
| Publication Year: |
2010 |
| Subject Terms: |
/dk/atira/pure/keywords/researchprograms/AFL001000/EMCNIHES026501; name=EMC NIHES-02-65-01 |
| Description: |
The antral follicle count (AFC) and anti-Mullerian hormone (AMH) both represent age-related follicular decline quite accurately, although long-term follow-up studies are still lacking. The best ovarian reserve test would need only a single, cycle-independent measurement to be representative. To compare the inter- and intra-cycle stability of AFC and AMH, we used age-adjusted intra-class correlation coefficients (ICCs). To measure inter-cycle stability across a number of up to four menstrual cycles, we used data, prospectively collected for the purpose of an other study, from 77 regularly cycling, infertile women aged 24-40 years. AMH and AFC values were measured on cycle day 3. To study intra-cycle variability, we used data from a prospective cohort study of 44 regularly cycling volunteers, aged 25-46 years and measured AMH and assessed the AFC (2-10 mm) every 1-3 cycle days. Between menstrual cycles, AFC and AMH varied between 0 and 25 follicles (median 10), and 0.3 and 27.1 ng/ml (median 4.64). The difference in age-adjusted ICC between AMH [ICC, 0.89 (95% CI, 0.84-0.94)] and AFC [ICC, 0.71 (95% CI, 0.63-0.77)] was 0.18 (95% CI, 0.12-0.27). For the intra-cycle variation, 0-43 antral follicles (median 7) were counted per volunteer. The difference in age-adjusted ICC between AMH [ICC, 0.87 (95% CI, 0.82-0.91)] and AFC [ICC, 0.69 (95% CI, 0.46-0.82)] was 0.18 (95% CI, 0.034-0.42). Serum AMH demonstrated less individual intra- and inter-cycle variation than AFCs and may therefore be considered a more reliable and robust means of assessing ovarian reserve in subfertile women. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| ISSN: |
0268-1161; 1460-2350 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/19840990; info:eu-repo/semantics/altIdentifier/pissn/0268-1161; info:eu-repo/semantics/altIdentifier/eissn/1460-2350 |
| DOI: |
10.1093/humrep/dep366 |
| Availability: |
https://pure.eur.nl/en/publications/e0be02bb-eba6-4b94-925d-05e9d274878a; https://doi.org/10.1093/humrep/dep366; https://hdl.handle.net/1765/27835 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.4F9B2F77 |
| Database: |
BASE |