| Title: |
Poster session 3 |
| Authors: |
Kokinas, K.C.; Fragakis, N.; Pagourelias, E.; Rossios, K.; Tanos, D.; Kyriakou, P.; Skeberis, V.; Katritsis, D.; Vassilikos, V.; Rodriguez Manero, M.; Otero-Ravina, F.; Garcia-Seara, J.; Garcia-Castelo, A.; Lado, M.; Vidal, J.M.; Vidal Perez, R.; Gonzalez Juanatey, J.R.; AFBAR study; Grigoryan, S.V.; Makaryan, Y.S.; Kuchmin, A.; Cherkashin, D.; Figueroa, J.A.; Estrada, A.; Doiny, D.; Castrejon-Castrejon, S.; Filgueiras, D.; De Pablos, L.; Battle, M.; Ortega, M.; Delgado, R.; Merino, J.L.; Vergara, P.; Oloriz Sanjuan, T.; Cireddu, M.; Fassini, G.; Rancoita, P.; Maccabelli, G.; Della Bella, P.; Castrejon, S.; De Juan, J.; Shachar, J.; Gang, E.; Mechakra, A.; Yang, Y-Q. YS.; Footz, T.F.; Walter, M.W.; Aranega-Jimenez, A. A-J.; Hernandez-Torres, F.; Morel, E.M.; Mllat, G.M.; Chevalier, P.C.; Christe, G.C.; Swarup, V.; Krummen, D.; Miller, J.; Shivkumar, K.; Narayan, S.; Multicenter Atrial Fibrillation Rotor Core Group; Kusayama, T.; Furusho, H.; Kanamori, N.; Chikata, A.; Kaneko, S.; Yamagishi, M.; Takamura, M.; Rubanenko, A.; Shchukin, Y.; Germanov, A.; Tereshina, O.; Rix, T.A.; Joensen, A.M.; Lundbye-Christensen, S.; Riahi, S.; Schmidt, E.B.; Overvad, K.; Paiva, L.V.; Providencia, R.; Barra, S.; Faustino, A.C.; Dinis, P.; Nascimento, J.; Botelho, A.M.; Leitao-Marques, A.; Caldwell, J.C.; Koppikar, S.; Barake, W.; Redfearn, D.; Michael, K.; Simpson, C.; Hopman, W.; Baranchuk, A.; Ramos, V.; Braga, C.; Martins, J.; Arantes, C.; Vieira, C.; Marques, J.; Gaspar, A.; Azevedo, P.; Alvares Pereira, M.; Correia, A.; Koziolova, N.; Shilova, Y.; Nikonova, J.; Polyanskaya, E.; Arbelo, E.; Berne, P.M.; Guiu, E.; Ramos, P.; Cabanas, P.; Andreu, D.; Bisbal, F.; Brugada, J.; Mont, L.L.; Spitzer, S.G.; Verma, A.; Debruyne, P.; Nardi, S.; Deneke, T.; De Greef, Y.; Balzer, J.; Boersma, L.; ERACE investigators; Acena, M.; Regoli, F.; Faletra, F.; Faragasso, E.; Klersy, C.; Auricchio, A.; Gabus, V.; Rollin, A.; Roux, Y.; Graf, D.; Schlaepfer, J.; Fromer, M.; Maury, P.; Pascale, P.; Forclaz, A.; Pruvot, E.; Kornej, J.; Kosiuk, J.; Arya, A.; Piorkowski, C.; Sommer, P.; Rolf, S.; Husser, D.; Hindricks, G.; Lip, G.; Bollmann, A.; De Buck, S.; Alzand, BSN.; Wielandts, J-Y.; Garweg, C.; Phlips, T.; Ector, J.; Nuyens, D.; Heidbuchel, H.; Shah, N.; Grover, P.; Patel, N.; Chothani, A.; Mehta, K.; Deshmukh, A.; Badheka, A.; Paydak, H.; Mitrani, R.D.; Viles-Gonzalez, J.; Piers, SRD.; Tao, Q.; Schalij, MJ.; Van Der Geest, RJ.; Zeppenfeld, K.; Piers, S.R.D.; Van Huls Van Taxis, C.F.B.; Schalij, M.J.; Van Der Geest, R.J.; Castrejon Castrejon, S.; Alejandro Estrada Mucci, A.E.M.; Marta Ortega Molina, M.O.M.; Jorge Figueroa, J.F.; David Doiny, D.D.; David Filgueiras Rama, D.F.; Jose Luis Lopez Sendon, J.L.S.; Jose Luis Merino Llorens, J.L.M.L.; Acena Ramos, M.; Dequarti, M.C.; Drasutiene, A.; Pasotti, E.; Moccetti, T.; Figueroa, JA.; Johnson, D.; Peinado, R.; Arrascaite, M.; Gonzalez-Torrecilla, E.; Arias-Palomares, M.A.; Tercedor, L.; Filgueiras-Rama, D.; Pachon, M.A.; Tortajada, G.; Garofalo, D.; Gomez Gallanti, A.; Matia, R.; Madrid, A.H.; Carrizo, L.; Delgado, A.; Del Castillo-Carnevalli, H.; Fernandez-Santos, S.; Lazaro, C.; Pindado, C.; Moro, C.; Zamorano, J.; Gonzalez-Zuelgaray, J.; De Valais, F.; Perez, A.; Szyszko, A.; Muratore, C.; Sciegata, A.; Hallon, L.; Carmo, P.; Adragao, P.; Cavaco, D.; Costa, F.; Santos, G.; Quaresma, R.; Teixeira, T.; Marques, M.; Abecasis, M.; Li, T.; Zhan, X.Z.; Xue, Y.-M.; Fang, X.H.; Liao, H.T.; Wu, S.L.; Zarse, M.; Bogossian, H.; Suleimann, H.; Ninios, I.; Mijic, D.; Karosiene, Z.; Hasan, F.; Kloppe, A.; Lemke, B.; Park, Y.M.; Sung, J.Y.; Lim, R.S.; Ko, K.J.; Lee, H.S.; Ban, J.E.; Choi, J.I.; Lim, H.E.; Park, S.W.; Kim, Y.H.; Muessigbrodt, A.; Dinov, B.; Fiedler, L.; Richter, S.; Breithardt, O.; Fichtner, S.; Estner, H.; Dzijan-Horn, M.; Herber, J.; Reents, T.; Ammar, S.; Semmler, V.; Dillier, R.; Hessling, G.; Deisenhofer, I.; Schoenbauer, R.; Bertagnolli, L.; Halianishcha, V.; Mrochek, A.; Goncharik, D.; Chasnoits, A.; Kovalenko, O.; Savchenko, A.; Rebeko, E.; Plashchinskaya, L.; Bandarchuk, A.; Sivak, S.; Watanabe, M.; Yokoshiki, H.; Mitsuyama, H.; Mizukami, K.; Tsutsui, H.; Kapel, G.F.L.; Brouwer, C.; De Riva Silva, M.; Thijssen, J.; Piers, S.R.; Van Der Heijden, A.C.; Meuwese, C.L.; Van Erven, L.; Biermann, J.; Haller, B.; Jilek, C.; Sarafoff, N.; Lennerz, C.; Vrazic, H.; Zrenner, B.; Asbach, S.; Kolb, C.; Suleiman, M.; The Israeli Working Group on Pacing and Electrophysiology; Cabrera Gomez, S.; Alonso Martin, C.; Guerra Ramos, J.; Rodriguez Font, E.; Mendez Zurita, F.; Sobre, M.; Magnani, S.; Vinolas Prat, X.; Rijnierse, M.T.; Allaart, C.P.; De Haan, S.; Harms, H.J.; Wu, L.; Danad, I.; Van Rossum, A.C.; Lammertsma, A.A.; Knaapen, P.; Arsenos, P.; Gatzoulis, K.; Manis, G.; Dilaveris, P.; Gialernios, T.; Kefala, A.; Tsiachris, D.; Aggelis, A.; Archontakis, S.; Stefanadis, C.; Vouliotis, A.; Johansen, J.B.; Kirkfeldt, R.E.; Nielsen, J.C.; Knops, R.; Nordekamp, L.O.; Lambiase, P.; Carter, N.; Reeve, H.; Theuns, D.; Olde Nordkamp, L.R.A.; Warnaars, J.L.F.; Wilde, A.A.M.; Knops, R.E.; Silva Cunha, P.; Martins Oliveira, M.; Nogueira Da Silva, M.; Agapito, A.; Sousa, L.; Trigo, C.; Fragata, J.; Cruz Ferreira, R.; Larsen, J.M.; Videbaek, R.; Haarbo, J.; Due, K.M.; Theuns, D.A.M.J.; Galvao Santos, P.; Mogado, F.; Mendes, M.; Zeb, M.; Chande, S.; Kwok, S.; Roberts, P.; Morgan, J.; Sanchez-Huete, G.; Del Castillo-Carnevali, H.; Kolodzinska, A.; Kutarski, A.; Wilczek, E.; Grabowski, M.; Koperski, L.; Kozlowska, M.; Gornicka, B.; Opolski, G.; Boehmer, J.; An, Q.; Zhang, Y.; Shih, A.; Moeller, V.; Seifert, M.; Schau, T.H.; Hoelschermann, F.; Butter, C.H.; Brahmbhatt, D H.; Watson, T J.; Prasad, R.; Ladwiniec, A.; Rafiq, I.; Nayar, V.; Chan, D.; Price, R.; Belham, M R D.; Pugh, P J.; Seifer, C.M.; Farag, A.; Cao, M.; Fischer, A.; Karst, E.; Sloman, L.; Desmond, M.; Turakhia, M.; Polewczyk, A.; Tomaszewski, A.; Boczar, K.; Janion, M.; Novikov, D.; Kandinsky, M.; Popov, S.; Vyskubova, E.; Yuriev, S.; Samoilov, A.; Latkin, M.; Mazza, A.; Bendini, M.G.; Leggio, M.; Riva, U.; Ciardiello, C.; De Cristofaro, R.; Giordano, G.; Kabutoya, T.; Mitsuhashi, T.; Watanabe, H.; Watanabe, T.; Nakagami, R.; Hata, Y.; Kario, K.; Brough, C.E.P.; Mcgee, C.; Rao, A.; Wright, D.J.; Alonso-Martin, C.; Guerra, J.; Rodriguez-Font, E.; Mendez, F.; Cabrera, S.; Varela, M.C.; Paz, E.; Vinolas, X.; Gulati, V.; Bhavnani, S.; Nair, S.U.; Friedman, M.; Kluger, J.; Almenar, L.; Sancho-Tello, M.; Fernandez-Lozano, I.; Cardiac resynchronization spanish working group; Dan, D.; Wickliffe, A.; Deering, T.; Kosmidou, I.; Renesto, F.; Cazeau, S.; ACCESS study investigators; Mollo, R.; Coviello, I.; Battipaglia, I.; Russo, G.; Villano, A.; Di Franco, A.; Careri, G.; Sestito, A.; Lanza, G.A.; Crea, F.; Covino, G.; Volpicelli, M.; Belli, P.; Ratti, G.; Tammaro, P.; Provvisiero, C.; Auricchio, L.; Fiorentino, C.; Capogrosso, P.; Geller, L.; Molnar, L.; Szilagyi, S.Z.; Tahin, T.; Kutyifa, V.; Solymossy, K.; Szeplaki, G.; Osztheimer, I.; Zima, E.; Merkely, B.; Sacchi, S.; Ricceri, I.; Attana', P.; Giomi, A.; Rossi, A.; Pieragnoli, P.; Ricciardi, G.; Perrotta, L.; Piacenti, M.; Padeletti, L.; Bakos, Z.; Markstad, H.; Ostenfeldt, E.; Carlsson, M.; Roijer, A.; Borgquist, R.; Simeonidou, E.; Vlami, K.; Ntai, K.; Koniari, K.; Iliodromitis, E.; Anastasiou-Nana, M.; Sturmer, M.; Dahl, K.; Vinet, A.; Jacquemet, V.; Dube, B.; Mahiddine, O.; Becker, G.; Kus, T.; Nadeau, R.; Sredniawa, B.; Cebula, S.; Mitrega, K.; Wozniak, A.; Musialik-Lydka, A.; Kowalczyk, J.; Kalarus, Z.; Gwizdala, A.; Straburzynska-Migaj, E.; Krauze, T.; Grajek, S.; Ochotny, R.; Szydlo, K.; Filipecki, A.; Orszulak, W.; Kwasniewski, W.; Urbanczyk, D.; Trusz-Gluza, M.; Mizia-Stec, K.; Cabanas Grandio, P.; Garcia Seara, J.; Martinez Sande, J.L.; Fernandez Lopez, X.A.; Berruezo, A.; Mont, L.; Lee, D.H.; Park, J.S.; Seo, J.M.; Choi, J.H.; Park, K.I.; Park, T.H.; Kim, M.H.; Kim, Y.D.; Choi, S.Y.; Rodriguez-Olivares, R.; Cozar Leon, R.; Francisco Aparicio, F.; Diaz-Infante, E.; Havranek, S.; Ambroz, D.; Wichterle, D.; Jansa, P.; Benjamin, M.N.; Olmedo, J.A.; Abello, M.S.; Moltedo, J.M.; El Mahmoudy, A.M.; Kawasaki, M.; Yamada, T.; Morita, T.; Furukawa, Y.; Iwasaki, Y.; Kikuchi, A.; Fukunami, M.; Boev, A.; Levitchi, A.; Josan, D. |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2013 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Monday 24 June 2013 |
| Description: |
Background: In experimental models, ranolazine exerts a synergistic effect which enhances amiodarone's potential to suppress atrial fibrillation (AF). The clinical effect of ranolazine added to amiodarone for AF conversion has only undergone minimal investigation. Purpose: This study compared the safety and effectiveness of ranolazine in combination with amiodarone versus amiodarone alone for conversion of paroxysmal AF. Methods: We prospectively enrolled all consecutive patients with paroxysmal AF who were deemed eligible for pharmacologic cardioversion. Exclusion criteria were QTc>440msec, hepatic, renal, or thyroid disorders, acute coronary syndrome, prior use of ranolazine, and use of strong CYP3A inhibitors which could affect ranolazine's metabolism. Patients were randomized to either iv amiodarone alone (loading dose of 5md/kg followed by a maintenance dose of 50mg/h for 24h), or to the combination of iv amiodarone plus a single oral dose of ranolazine 1500mg. Patients remained on continuous ECG monitoring. We measured the time to conversion to sinus rhythm, and the proportion of patients with AF conversion within 12h and within 24h. Results: 72 patients were enrolled (mean age 59±7 years): 35 in the amiodarone-only group and 37 in the amiodarone plus ranolazine combination group. The two groups did not differ in terms of clinical characteristics and echocardiographic parameters, including left atrium diameter. Time to conversion was shorter in the combination group compared with the amiodarone-only group (8.4±3.8h vs.15.1±4.8 h; p550msec) and no proarrhythmic events in either treatment group. Conclusions: The addition of ranolazine to standard amiodarone treatment is safe, and it leads to faster conversion of paroxysmal AF. Consistent with ... |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://europace.oxfordjournals.org/cgi/content/short/15/suppl_2/ii82; http://dx.doi.org/10.1093/europace/eut173 |
| DOI: |
10.1093/europace/eut173 |
| Availability: |
http://europace.oxfordjournals.org/cgi/content/short/15/suppl_2/ii82; https://doi.org/10.1093/europace/eut173 |
| Rights: |
Copyright (C) 2013, European Heart Rhythm Association of the European Society of Cardiology (ESC) |
| Accession Number: |
edsbas.4FA306C8 |
| Database: |
BASE |