Additional file 5 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma
| Title: | Additional file 5 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma |
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| Authors: | Benjamin Lin; Abigail K. Shelton; Erin Smithberger; Julia Ziebro; Kasey R. Skinner; Ryan E. Bash; Richard Kirkman; Allie Stamper; Madison Butler; Alex Flores; Steven P. Angus; Michael P. East; Timothy F. Cloughesy; David A. Nathanson; Michael E. Berens; Jann N. Sarkaria; Zev A. Binder; Donald M. O’Rourke; Timothy C. Howton; Brittany N. Lasseigne; Christopher D. Willey; Gary L. Johnson; Anita B. Hjelmeland; Frank B. Furnari; C. Ryan Miller |
| Publication Year: | 2025 |
| Collection: | The University of Auckland: Figshare |
| Subject Terms: | Biochemistry; Medicine; Genetics; Pharmacology; Biotechnology; Marine Biology; Cancer; Hematology; Virology; Computational Biology; Biological Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; EGFR; Glioblastoma; Synthetic lethality; Kinome rewiring; Upfront combinatorial therapy |
| Description: | Supplementary Material 5: Fig. S4 DE kinases in acquired resistant cell lines cultured in full serum. Volcano plots of DE kinases (limma FDR < 0.05) are shown for the following resistant lines compared to parental CEv3 cells: E4 (A), E5 (B), G1 (C), G5 (D), G8 (E), and G12 (F). Volcano plots show genes upregulated in acquired resistance on the right and genes upregulated in sensitive CEv3 cells on the left |
| Document Type: | still image |
| Language: | unknown |
| DOI: | 10.6084/m9.figshare.29431984.v1 |
| Availability: | https://doi.org/10.6084/m9.figshare.29431984.v1; https://figshare.com/articles/figure/Additional_file_5_of_Identifying_and_exploiting_combinatorial_synthetic_lethality_by_characterizing_adaptive_kinome_rewiring_of_EGFRvIII-driven_glioblastoma/29431984 |
| Rights: | CC BY |
| Accession Number: | edsbas.4FB18D4 |
| Database: | BASE |