Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study
| Title: | Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study |
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| Authors: | Bruno R. M.; Badhwar S.; Abid L.; Agharazii M.; Anastasio F.; Bellien J.; Burghuber O.; Faconti L.; Filipovsky J.; Ghiadoni L.; Giannattasio C.; Hametner B.; Hughes A. D.; Jeroncic A.; Ikonomidis I.; Lonnebakken M. T.; Maloberti A.; Mayer C. C.; Muiesan M. L.; Paini A.; Panayiotou A.; Park C.; Rajkumar C.; Becerra C. R.; Spronck B.; Terentes-Printzios D.; Tuncok Y.; Weber T.; Boutouyrie P.; Almhofer H.; Danninga K.; Algner M.; Wernhart M.; Azizzadeh M.; Breyer M. -K.; Bortolotto L.; Vilela-Martin J. F.; Toshiro Passos Okawa R.; Lyrio Bermudes Okawa J.; Sebba Barroso W. K.; Gomes Ciolac E.; do Amaral V. T.; Fernandez B.; Goupil R.; Fortier C.; Photiou G.; Mayer O.; Seidlerova J.; Pazdiora P.; Hirmerova J.; Sustkova L.; Bilkova S.; Gelzinsky J.; Kordikova V.; Mares S.; Cifkova R.; Wohlfahrt P.; Kavalirova J.; Khettab H.; Justin J.; Moriconi D.; Fabbri S.; Hulot J. S.; Fayol A.; Courbebaisse M.; Parfait B.; Lebeaux D.; Friedlander G.; Joannides R.; Iacob M.; Leroi A. -M.; Benetos A.; Georgiopoulos I.; Christopoulou G.; Tsioufis K.; Gardikioti V.; Vlachopoulos C.; Lambadiari V.; Kountouri A.; Katogiannis K.; Podrug M.; Pavicic-Ivelja M.; Koren P.; Salvetti M.; Cacciatore M.; Pucci G.; Scarnecchia E.; Alessandro M.; Algeri M.; Moreo A.; Tognola C.; Grillo A.; Fabris B.; Bernardi S.; Rovina M.; Di Pierro G.; Armenia S.; Bianchini E.; Zanoli L.; Castellino P.; Montineri A.; Sciuto A.; Grassi D.; Badariene J.; Ryliskyte L.; Laucyte-Cibulskiene A.; Jancoriene L.; Ryliskiene K.; Juceviciene A.; Kovaite M.; Balkeviciene L.; Alanis-Sanchez G.; Martinez-Ayala P.; Cardona-Munoz E. G.; Cardona-Muller D.; Berge C. A.; Bohn L.; Oliveira J.; Alves E.; Costa S. P.; Pereira T.; Caseiro A.; Lira F.; Bernal Lopez M. R.; Ruiz Moreno M. I.; Gomez Huelgas R.; Lopez Sampalo A.; Sanz Canovas J.; Vargas Cancela V. A.; Cobos Palacios L.; Mancebo Sevilla J. J.; Zeka A. N.; Ozpelit E.; Incir C.; Baris M. M.; Canturk A.; Cimilli H. C.; Abdessalem S.; Charfeddine S.; Bahloul A.; Hammami R.; Walha M.; Jamieson A.; Chowienczyk P. J.; Farukh B.; Akhtar R.; Shantsila A.; Lip G.; Gurovich A. N.; Gomez M.; Stoner L.; Meyer M.; Hanson E.; Zieff G.; Lassalle P. P.; Bates L. |
| Contributors: | Bruno, R; Badhwar, S; Abid, L; Agharazii, M; Anastasio, F; Bellien, J; Burghuber, O; Faconti, L; Filipovsky, J; Ghiadoni, L; Giannattasio, C; Hametner, B; Hughes, A; Jeroncic, A; Ikonomidis, I; Lonnebakken, M; Maloberti, A; Mayer, C; Muiesan, M; Paini, A; Panayiotou, A; Park, C; Rajkumar, C; Becerra, C; Spronck, B; Terentes-Printzios, D; Tuncok, Y; Weber, T; Boutouyrie, P; Almhofer, H; Danninga, K; Algner, M; Wernhart, M; Azizzadeh, M; Breyer, M; Bortolotto, L; Vilela-Martin, J; Toshiro Passos Okawa, R; Lyrio Bermudes Okawa, J; Sebba Barroso, W; Gomes Ciolac, E; Do Amaral, V; Fernandez, B; Goupil, R; Fortier, C; Photiou, G; Mayer, O; Seidlerova, J; Pazdiora, P; Hirmerova, J; Sustkova, L; Bilkova, S; Gelzinsky, J; Kordikova, V; Mares, S; Cifkova, R; Wohlfahrt, P; Kavalirova, J; Khettab, H; Justin, J; Moriconi, D; Fabbri, S; Hulot, J; Fayol, A; Courbebaisse, M; Parfait, B; Lebeaux, D; Friedlander, G; Joannides, R; Iacob, M; Leroi, A; Benetos, A; Georgiopoulos, I; Christopoulou, G; Tsioufis, K; Gardikioti, V; Vlachopoulos, C; Lambadiari, V; Kountouri, A; Katogiannis, K; Podrug, M; Pavicic-Ivelja, M; Koren, P; Salvetti, M; Cacciatore, M; Pucci, G; Scarnecchia, E; Alessandro, M; Algeri, M; Moreo, A; Tognola, C; Grillo, A; Fabris, B; Bernardi, S; Rovina, M; Di Pierro, G; Armenia, S; Bianchini, E |
| Publisher Information: | GB; Oxford University Press |
| Publication Year: | 2025 |
| Collection: | Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: | Arterial stiffne; COVID-19; Long COVID; Sex difference; Vascular ageing |
| Description: | Background and Increasing evidence suggests that COVID-19 survivors experience long-term cardiovascular complications possibly through Aims development of vascular damage. The study aimed to investigate whether accelerated vascular ageing occurs after COVID-19 infection, and if so, identify its determinants. Methods This prospective, multicentric, cohort study, included 34 centres in 16 countries worldwide, in 4 groups of participants—COVID-19-negative controls (i) and three groups of individuals with recent (6 ± 3 months) exposure to SARS-CoV-2: not hospitalized (ii), hospitalized in general wards (iii), and hospitalized in intensive care units (iv). The main outcome was carotid-femoral pulse wave velocity (PWV), an established biomarker of large artery stiffness. Results 2390 individuals (age 50 ± 15 years, 49.2% women) were recruited. After adjustment for confounders, all COVID-19-positive groups showed higher PWV (+0.41, +0.37, and +0.40 m/s for groups 2–4, P < .001, P = .001 and P = .003) vs. controls [PWV 7.53 (7.09; 7.97) m/s adjusted mean (95% CI)]. In sex-stratified analyses, PWV differences were significant in women [PWV (+0.55, +0.60, and +1.09 m/s for groups 2–4, P < .001 for all)], but not in men. Among COVID-19 positive women, persistent symptoms were associated with higher PWV, regardless of disease severity and cardiovascular confounders [adjusted PWV 7.52 (95% CI 7.09; 7.96) vs. 7.13 (95% CI 6.67; 7.59) m/s, P < .001]. A stable or improved PWV after 12 months was found in the COVID+ groups, whereas a progression was observed in the COVID− group. Conclusions COVID-19 is associated with early vascular ageing in the long term, especially in women. |
| Document Type: | article in journal/newspaper |
| File Description: | STAMPA |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/40819656; info:eu-repo/semantics/altIdentifier/wos/WOS:001552455800001; volume:46; issue:39; firstpage:3905; lastpage:3918; numberofpages:14; journal:EUROPEAN HEART JOURNAL; https://hdl.handle.net/10281/578186 |
| DOI: | 10.1093/eurheartj/ehaf430 |
| Availability: | https://hdl.handle.net/10281/578186; https://doi.org/10.1093/eurheartj/ehaf430 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative Commons ; license uri:http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: | edsbas.4FFBB2B9 |
| Database: | BASE |