| Title: |
Predictive value for intravenous immunoglobulin resistance of Kobayashi and Kawanet scores in 722 children with Kawasaki disease across diverse ethnic backgrounds (KIWI study): an international cohort studyResearch in context |
| Authors: |
Maria Vincenza Mastrolia; Vignesh Pandiarajan; Marco Cattalini; Andrea Taddio; Stefania Vergnano; Jordi Anton; Watchareewan Sontichai; Betul Sozeri; Seza Ozen; Silvia Rosina; Judith Sánchez-Manubens; Ruby Haviv; Priyankar Pal; Adriana Rodrigues Fonseca; Alenka Gagro; Narendra Kumar Bagri; Lucio Verdoni; Davide Montin; Maria Cristina Maggio; Abarna Thangaraj; Rakesh Pilania; Manuel Mosquera; Joan Calzada; Rekwan Sittiwangkul; Kadir Ulu; Zeynep Balik; Yelda Bilginer; Marco Garrone; Elisa Patrone; Elisa Barbi; Giulia Ciacci; Andrea Barucci; Nicolino Ruperto; Gabriele Simonini |
| Source: |
EClinicalMedicine, Vol 93, Iss , Pp 103813- (2026) |
| Publisher Information: |
Elsevier |
| Publication Year: |
2026 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Kawasaki disease; IVIg-resistance; Kobayashi score; Kawanet score; Medicine (General); R5-920 |
| Description: |
Summary: Background: Intravenous immunoglobulin (IVIg) resistance affects 15–25% of children with Kawasaki disease (KD) and increases the risk of coronary artery abnormalities (CAA). The Kobayashi score has shown good predictive value in Japanese cohorts but limited accuracy in non-Asian populations. The Kawanet model was proposed as an alternative with improved applicability in non-Asian settings. Methods: A retrospective–prospective, observational, multicentre cohort study including children fulfilling the American Heart Association criteria for KD was conducted. The availability of all clinical and laboratory variables required to calculate both the Kobayashi and Kawanet IVIg-resistance scores was mandatory for inclusion (sodium, neutrophil percentage, AST, platelet count, CRP, age, illness days at first IVIg administration, ALT, hepatomegaly, lymphocyte count, time to treatment). All included patients were aged |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISBN: |
978-2-589-53702-3; 2-589-53702-6 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S258953702600060X; https://doaj.org/toc/2589-5370; https://doaj.org/article/e65c86956d5f4618ba2ad5aae703b53c |
| DOI: |
10.1016/j.eclinm.2026.103813 |
| Availability: |
https://doi.org/10.1016/j.eclinm.2026.103813; https://doaj.org/article/e65c86956d5f4618ba2ad5aae703b53c |
| Accession Number: |
edsbas.500DE3E6 |
| Database: |
BASE |