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Outcome of COVID-19 in Patients with Mantle Cell Lymphoma—Report from the European MCL Registry

Title: Outcome of COVID-19 in Patients with Mantle Cell Lymphoma—Report from the European MCL Registry
Authors: Tilch, Marie Kristin; Visco, Carlo; Kinda, Sandra Bašić; Hermine, Olivier; Kohn, Milena; Besson, Caroline M.; Lamure, Sylvain; Duléry, Rémy; Ragaini, Simone; Eyre, Toby Andrew; van Meerten, Tom; Ohler, Anke; Eckerle, Steffen; Dreyling, Martin H.; Hess, Geoŗge R.; Giné, Eva; da Silva, Maria Gomes
Contributors: Universitätsmedizin der Johannes Gutenberg-Universität Mainz - University Medical Center of the Johannes Gutenberg-University Mainz Germany; Università degli studi di Verona = University of Verona (UNIVR); University Hospital Centre Zagreb; Partenaires INRAE; Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Centre Hospitalier de Versailles André Mignot (CHV); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ); Institut de Génétique Moléculaire de Montpellier (IGMM); Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Centre de Recherche Saint-Antoine (CRSA); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Università degli studi di Torino = University of Turin (UNITO); Churchill Hospital Breast Care Unit; Churchill Hospital Oxford Centre for Haematology; University of Groningen Groningen; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Universitat de Barcelona (UB); Novartis; Roche; Sanofi; Gilead Sciences; Alexion Pharmaceuticals; Celgene; AbbVie; Janssen Pharmaceuticals; M-KT received speakers’ honoraria from Astra Zeneca, Shire Takeda, Hexal. CV served as a advisory board or scientific advisor for Roche, Gilead, Incyte, Beigene, AbbVie, Janssen, Takeda, Novartis, and received research funding from Jannsen, Gentili. SK received honoraria and advisory board for Roche, Sandoz, and Octapharm/Celtrion. OH received grants from Celgene, Alexion, AB Science, and Inatherys. SL received miscellaneous support from Janssen, Gilead, Roche, Abbvie, Sanofi, Novartis, Actelion, Pfizer, honorarium from Gilead, and a research grant from Janssen. RD received personal fees from Takeda, Novartis, and Biotest, nonfinancial support from Gilead. MGdS received research support, travel to scientific conferences, advisory boards from Gilead; research support from Astrazeneca; travel to scientific conferences, advisory boards from Abbvie; advisory boards from JC; travel to scientific conferences, advisory boards, trial steering committee from Roche; advisory boards from Takeda; advisory boards from Bristol Myers Squibb; advisory boards from ADC Therapeutics; and advisory board from Celgene. EG received honoraria from Gilead/Kite, Janssen, Genmab; served as consulting or advisory role in Gilead/Kite; and research Funding from Janssen. TE received honorarium, advisory board honorarium from Roche; received honorarium; research support; and travel to scientific conferences from Gilead; advisory board honorarium from KITE; honorarium from Janssen; honorarium and Travel to scientific conferences from Abbvie; AstraZeneca: Honorarium, Research funding, Loxo Oncology: Advisory Board Honorarium, Trial steering committee, Beigene: Advisory Board Honorarium, Research funding, Incyte: Advisory Board Honorarium, Secura Bio: Advisory Board Honorarium. MD is a HemaSphere editor, receives funding by Abbvie, Bayer, Celgene, Gilead/Kite, Janssen; speaker’s honoraria from Amgen, Astra Zeneca, Bayer, Celgene, Gilead/Kite, Incyte, Janssen, Novartis, Roche; advisory honoraria from Astra Zeneca, Bayer, Beigene, Celgene, Genmab, Gilead/Kite, Incyte, Janssen, Lilly/Loxo, Morphosys, Novartis, Roche. GH receives funding by Roche, Janssen Pharmaceuticals, Celgene and Gilead and speaker’s or advisory honoraria from Janssen, Roche, Celgene, Gilead, Novartis, Incyte, Genmab, Morphosys, Abbvie, and Astra. All the other authors have no conflicts of interest to disclose.
Source: ISSN: 2572-9241 ; HemaSphere ; https://hal.science/hal-03673380 ; HemaSphere, 2022, 6 (5), pp.e0711. ⟨10.1097/HS9.0000000000000711⟩.
Publisher Information: CCSD; Lippincott, Williams & Wilkins
Publication Year: 2022
Collection: Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ
Subject Terms: [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology
Description: International audience ; Data on outcome of patients with mantle cell lymphoma (MCL) and COVID-19 infection are limited. The European MCL (EMCL) registry is a centralized registry of the EMCL network, collecting real-world information about treatments and disease courses. During the COVID-19 pandemic, additional data on MCL patients with COVID-19 infection were collected, aiming to identify risk factors for mortality from COVID-19. In our retrospective, multicenter, international study, we collected data from 63 MCL patients with a median age of 64 years (range, 44–84) in 9 countries with evidence of a COVID-19 infection between February 2020 and October 2021. The overall mortality rate was high (44.4%), especially in hospitalized patients (61%) and in patients with need for intensive care unit care (94%). Patients receiving rituximab had significantly poorer survival than patients not receiving rituximab (P=0.04). Our data highlight the importance of prevention strategies and underline the need for effective vaccination in this vulnerable cohort.
Document Type: article in journal/newspaper
Language: English
Relation: PUBMEDCENTRAL: PMC9000040
DOI: 10.1097/HS9.0000000000000711
Availability: https://hal.science/hal-03673380; https://hal.science/hal-03673380v1/document; https://hal.science/hal-03673380v1/file/hs9-6-e0711.pdf; https://doi.org/10.1097/HS9.0000000000000711
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess
Accession Number: edsbas.50F11AF9
Database: BASE