| Title: |
Pharmacotherapy of Traumatic Childhood Aphasia: Beneficial Effects of Donepezil Alone and Combined With Intensive Naming Therapy |
| Authors: |
Dávila, Guadalupe; Moyano, María Pilar; Edelkraut, Lisa; Moreno-Campos, Lorena; Berthier, Marcelo L.; Torres-Prioris, María José; López-Barroso, Diana |
| Contributors: |
Dávila,G; Moyano,MP; Edelkraut,L; Moreno-Campos,L; Berthier,ML; Torres-Prioris,MJ; López-Barroso,D Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, University of Malaga, Malaga, Spain. Dávila,G; López-Barroso,D Instituto de Investigación Biomédica de Málaga - IBIMA, Málaga, Spain. Dávila,G; López-Barroso,D Department of Psychobiology and Methodology of Behavioural Sciences, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain. Dávila,G; López-Barroso,D Language Neuroscience Research Laboratory, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga, Spain.; MM has been funded by I Plan for Research and Transfer of the University of Malaga (Introduction to Research Scholarship for Undergraduate and Master’s Students, 107/2018). LM-C has been supported by funds from the European Social Fund (E-29-201-0705972). LE has been funded by a PhD scholarship from the Spanish Ministry of Education, Culture, and Sport under the FPU program (FPU17/04136). MT-P has been funded by a postdoctoral fellowship from the University of Malaga. DL-B has been supported by a I+D+i Project, Andalucia and European Union Funds (FEDER) (UMA18-FEDERJA-221). The work was supported in part by the Ministerio de Economía, Industria y Competitividad, Instituto de Salud Carlos III, Madrid, Spain under Grant: PI16/01514. |
| Publisher Information: |
Frontiers |
| Publication Year: |
2020 |
| Collection: |
Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| Subject Terms: |
Language; Childhood aphasia; Anomia; Traumatic brain injury; Donepezil; Pharmacological treatment; Intensive naming therapy; Lenguaje; Afasia; Lesiones traumáticas del encéfalo; Donepezilo; Preparaciones farmacéuticas; Infancia; Pruebas del lenguaje; Niño; Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Communication::Language; Medical Subject Headings::Diseases::Pathological Conditions; Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Neurobehavioral Manifestations::Communication Disorders::Language Disorders::Anomia; Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations; Medical Subject Headings::Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Language Tests; Medical Subject Headings::Persons::Persons::Age Groups::Child; Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans; Medical Subject Headings::Analytical; Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Rehabilitation::Rehabilitation of Speech and Language Disorders::Speech Therapy; Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Nervous System Physiological Processes::Speech; Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Rehabilitation::Rehabilitation of Speech and Language Disorders::Language Therapy; Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition::Comprehension; Medical Subject Headings::Diseases::Nervous System Diseases::Neurologic Manifestations::Neurobehavioral Manifestations::Communication Disorders::Language Disorders::Speech Disorders::Aphasia; Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Psychophysiology::Arousal::Attention; Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Neurotransmitter Agents::Cholinergic Agents |
| Description: |
At present, language therapy is the only available treatment for childhood aphasia (CA). Studying new interventions to augment and hasten the benefits provided by language therapy in children is strongly needed. CA frequently emerges as a consequence of traumatic brain injury and, as in the case of adults, it may be associated with dysfunctional activity of neurotransmitter systems. The use of cognitive-enhancing drugs, alone or combined with aphasia therapy, promotes improvement of language deficits in aphasic adults. In this study we report the case of a 9-year-old right-handed girl, subject P, who had chronic anomic aphasia associated with traumatic lesions in the left temporal-parietal cortex. We performed a single-subject, open-label study encompassing administration of the cholinergic agent donepezil (DP) alone during 12 weeks, followed by a combination of DP and intensive naming therapy (INT) for 2 weeks and thereafter by a continued treatment of DP alone during 12 weeks, a 4-week washout period, and another 2 weeks of INT. Four comprehensive language and neuropsychological evaluations were performed at different timepoints along the study, and multiple naming evaluations were performed after each INT in order to assess performance in treated and untreated words. Structural magnetic resonance imaging (MRI) was performed at baseline. MRI revealed two focal lesions in the left hemisphere, one large involving the posterior inferior and middle temporal gyri and another comprising the angular gyrus. Overall, baseline evaluation disclosed marked impairment in naming with mild-to-moderate compromise of spontaneous speech, repetition, and auditory comprehension. Executive and attention functions were also affected, but memory, visuoconstructive, and visuoperceptive functions were preserved. Treatment with DP alone significantly improved spontaneous speech, auditory comprehension, repetition, and picture naming, in addition to processing speed, selective, and sustained attention. Combined DP-INT further improved ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| Language: |
English |
| ISSN: |
32848757; 1663-9812 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fphar.2020.01144/full; Dávila G, Moyano MP, Edelkraut L, Moreno-Campos L, Berthier ML, Torres-Prioris MJ, López-Barroso D. Pharmacotherapy of Traumatic Childhood Aphasia: Beneficial Effects of Donepezil Alone and Combined With Intensive Naming Therapy. Front Pharmacol. 2020 Jul 31;11:1144; http://hdl.handle.net/10668/3652; PMC7411310 |
| DOI: |
10.3389/fphar.2020.01144 |
| Availability: |
http://hdl.handle.net/10668/3652; https://doi.org/10.3389/fphar.2020.01144 |
| Rights: |
Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0/ ; Acceso abierto |
| Accession Number: |
edsbas.513EF6F2 |
| Database: |
BASE |