| Title: |
Molecular docking and dynamics simulation of some dual CK2/HDAC inhibitors targeting histone deacetylase1 |
| Authors: |
Klenina , O. V.; Márquez Cantudo, Laura; Coderch, Claire; Fernandez, Beatriz de Pascual-Teresa |
| Source: |
Current chemical problems; 2025; 55-55 ; Хімічні проблеми сьогодення; 2025; 55-55 ; 2708-0544 ; 2708-0536 |
| Publisher Information: |
Current chemical problems; Хімічні проблеми сьогодення |
| Publication Year: |
2025 |
| Description: |
Histone deacetylases (HDACs) are a family of epigenetic proteins that control gene transcription and regulation, alongside cell proliferation, differentiation, migration, death, and angiogenesis [1]. Histone deacetylase inhibitors (HDACi) have vast potential as therapeutic agents for the treatment of cancer and have demonstrated anticancer efficacy across a range of cancers, most impressively in haematological malignancies [2]. One of the rapidly growing fields of research in anticancer therapy is the construction of dual HDAC/kinase inhibitors, a few of them are currently in preclinical and clinical trials [3]. Some novel CK2/HDAC inhibitors were synthesized at the Department of Chemistry and Biochemistry, San Pablo CEU University, Madrid, Spain, through combining the distinct pharmacophores of Tucidinostat and CX-4945. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://jhps.donnu.edu.ua/article/view/17391/17282; https://jhps.donnu.edu.ua/article/view/17391 |
| Availability: |
https://jhps.donnu.edu.ua/article/view/17391 |
| Accession Number: |
edsbas.518164F3 |
| Database: |
BASE |