| Title: |
The role of palladin in pancreatic cancer |
| Authors: |
Stack, Christianna. |
| Contributors: |
Otey, Carol A. |
| Publisher Information: |
University of North Carolina at Chapel Hill. Library; University of North Carolina at Chapel Hill |
| Publication Year: |
2008 |
| Collection: |
University of North Carolina: UNC Digital Collections |
| Description: |
Palladin is a phosphoprotein with a role in regulating the actin cytoskeleton. Recently, palladin was identified as being overexpressed and mutated in a form of familial pancreatic cancer, an extremely lethal disease. Protein expression studies indicated that palladin was overexpressed in the tumor cells, but immunohistochemistry data from a separate study showed that palladin was actually overexpressed in the non-neoplastic stroma of a pancreatic tumor. The goal of this study was to determine which cell type overexpressed palladin using various palladin antibodies. We found that the fibroblasts in the stroma of a pancreatic tumor overexpressed multiple isoforms of palladin. The palladin expression occurs in a population of fibroblasts in the tumor microenvironment known as tumor-associated fibroblasts. These cells resemble the fibroblasts present in healing wounds, a cell type where palladin is also expressed. The consequence of palladin upregulation in these cells in the context of a pancreatic tumor is unknown. |
| Document Type: |
thesis |
| File Description: |
987.69 KB |
| Language: |
English |
| Relation: |
http://dc.lib.unc.edu/u?/etd,2072 |
| Availability: |
http://dc.lib.unc.edu/u?/etd,2072 |
| Rights: |
Author ; The author has granted the University of North Carolina at Chapel Hill a limited, non-exclusive right to make this publication available to the public. The author retains all other rights. |
| Accession Number: |
edsbas.51A518B5 |
| Database: |
BASE |