| Title: |
Use of a biomimetic scaffold for the treatment of osteochondral lesions in early osteoarthritis |
| Authors: |
Condello V; Filardo G; Madonna V; Andriolo L; Screpis D; Bonomo M; Zappia M; Giudici LD; Zorzi C |
| Contributors: |
Condello, V; Filardo, G; Madonna, V; Andriolo, L; Screpis, D; Bonomo, M; Zappia, M; Giudici, Ld; Zorzi, C |
| Publication Year: |
2018 |
| Collection: |
Università degli Studi del Molise: IRIS |
| Description: |
The aim of this study is to investigate clinical and radiographic outcomes of a biomimetic scaffold for the treatment of osteochondral knee lesions in patients with early OA. Study population was represented by 26 patients with a mean age of 44 years affected by early OA. Inclusion criteria were two episodes of knee pain for more than 10 days in the last year, Kellgren-Lawrence OA grade 0 or I or II, and arthroscopic findings of cartilage defects. Nineteen patients had a previous surgery, 11 of which were revision surgeries of osteochondral unit. All patients were treated with a biomimetic scaffold with a tri-layered structure of type I equine collagen and magnesium-enriched hydroxyapatite. Clinical outcomes were evaluated using the IKDC, Lysholm, VAS, KOOS, and Tegner scores at baseline and at an average follow-up of 35 months. Magnetic resonance imaging (MRI) was performed at follow-up time in 19 patients. Clinical outcomes showed significant improvement in VAS, Lysholm, IKDC subjective score, and KOOS subscales in 69% of the patients. Complication rate of this cases series was 11%, with no surgical failure, although 31% of patients did not reach a significant improvement and were thus considered as clinical failure. MRI analysis showed integration of the scaffold only in 47% of the patients, with partial regeneration of the subchondral bone. No correlation between clinics and radiological images was found. The use of a biomimetic osteochondral scaffold in the setting of an early OA, alone or associated with other procedures, appeared to be a valid and safe option, able to provide good and stable clinical outcomes with high patient’s satisfaction and low complication rate. Copyright © 2018 Vincenzo Condello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
journal:BIOMED RESEARCH INTERNATIONAL; https://hdl.handle.net/11695/106907 |
| DOI: |
10.1155/2018/7937089 |
| DOI: |
10.1155/2018/7937089&partnerID=40&md5=a67f7b180e8511ad20c0d741685d30bd |
| Availability: |
https://hdl.handle.net/11695/106907; https://doi.org/10.1155/2018/7937089; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062859222&doi=10.1155/2018/7937089&partnerID=40&md5=a67f7b180e8511ad20c0d741685d30bd |
| Accession Number: |
edsbas.51C681EC |
| Database: |
BASE |