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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Title: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Authors: Okbay, Aysu; Baselmans, BML; De Neve, JE; Turley, P; Nivard, MG; Fontana, MA; Meddens, SFW; Linner, RK; Rietveld, CA; Derringer, J; Gratten, J; Lee, JJ; Liu, JZ; de Vlaming, R; Ahluwalia, TS; Buchwald, J; Cavadino, A; Frazier-Wood, AC; Furlotte, NA; Garfield, V; Geisel, MH; Gonzalez, JR; Haitjema, S; Karlsson, R; Laan, Sander; Ladwig, KH; Lahti, J; van der Lee, Sven; Lind, PA; Liu, T; Matteson, L; Mihailov, E; Miller, MB; Minica, CC; Nolte, IM (Ilja); Mook-Kanamori, D; van der Most, PJ; Oldmeadow, C; Qian, Y; Raitakari, O; Rawal, R; Realo, A; Rueedi, R; Schmidt, B; Smith, AV; Stergiakouli, E; Tanaka, T; Taylor, K; Wedenoja, J; Wellmann, J; Westra, HJ; Willems, SM; Zhao, W; Amin, Najaf; Bakshi, A; Boyle, PA; Cherney, S; Cox, SR; Davies, G; Davis, OSP; Ding, J; Direk, Nese; Eibich, P; Emeny, RT; Fatemifar, G; Faul, JD; Ferrucci, L; Forstner, A; Gieger, C; Gupta, R; Harris, TB; Harris, JM; Holliday, EG; Hottenga, JJ (Jouke Jan); De Jager, PL; Kaakinen, MA; Kajantie, E; Karhunen, V; Kolcic, I; Kumari, M; Launer, LJ (Lenore); Franke, L; Li-Gao, R; Koini, M; Loukola, A; Marques-Vidal, P; Montgomery, GW; Mosing, MA; Paternoster, L; Pattie, A; Petrovic, KE; Pulkki-Raback, L; Quaye, L; Raikkonen, K; Rudan, I; Scott, RJ; Smith, JA; Sutin, AR; Trzaskowski, M; Vinkhuyzen, AE; Yu, L; Zabaneh, D; Attia, JR; Bennett, DA; Berger, K; Bertram, L; Boomsma, DI; Snieder, H; Chang, SC; Cucca, F; Deary, IJ; Duijn, Cornelia; Eriksson, JG; Bultmann, U; de Geus, EJC; Groenen, PJF; Gudnason, V; Hansen, T; Hartman, CA; Haworth, CMA; Hayward, C; Heath, AC; Hinds, DA; Hypponen, E; Iacono, WG; Jarvelin, MR; Jockel, KH; Kaprio, J; Kardia, SLR; Keltikangas-Jarvinen, L; Kraft, P; Kubzansky, LD; Lehtimaki, T; Magnusson, PKE; Martin, NG; McGue, M; Metspalu, A; Mills, M; de Mutsert, R; Oldehinkel, AJ (A.); Pasterkamp, G; Pedersen, NL; Plomin, R; Polasek, O; Power, C; Rich, SS; Rosendaal, FR; den Ruijter, HM; Schlessinger, D; Schmidt, Heléna; Svento, R; Schmidt, R; Alizadeh, BZ; Sorensen, TIA; Spector, TD; Steptoe, A; Terracciano, A; Thurik, AR; Timpson, NJ; Tiemeier, Henning; Uitterlinden, André; Vollenweider, P; Wagner, GG; Weir, DR; Yang, Jiaqi; Conley, DC; Smith, GD; Hofman, Bert; Johannesson, M; Laibson, DI; Medland, SE; Meyer, MN; Pickrell, JK; Esko, T; Krueger, RF; Beauchamp, JP; Koellinger, PD; Benjamin, DJ; Bartels, MC; Cesarini, D
Source: Okbay, A, Baselmans, BML, De Neve, JE, Turley, P, Nivard, MG, Fontana, MA, Meddens, SFW, Linner, RK, Rietveld, CA, Derringer, J, Gratten, J, Lee, JJ, Liu, JZ, de Vlaming, R, Ahluwalia, TS, Buchwald, J, Cavadino, A, Frazier-Wood, AC, Furlotte, NA, Garfield, V, Geisel, MH, Gonzalez, JR, Haitjema, S, Karlsson, R, Laan, S, Ladwig, KH, Lahti, J, van der Lee, S, Lind, PA, Liu, T, Matteson, L, Mihailov, E, Miller, MB, Minica, CC, Nolte, IM, Mook-Kanamori, D, van der Most, PJ, Oldmeadow, C, Qian, Y, Raitakari, O, Rawal, R, Realo, A, Rueedi, R, Schmidt, B, Smith, AV, Stergiakouli, E, Tanaka, ....
Publication Year: 2016
Subject Terms: /dk/atira/pure/keywords/researchprograms/AFL000300/EURESE31; name=EUR ESE 31; /dk/atira/pure/keywords/researchprograms/AFL001000/EMCMM013909A; name=EMC MM-01-39-09-A; /dk/atira/pure/keywords/researchprograms/AFL001000/EMCNIHES016401; name=EMC NIHES-01-64-01; /dk/atira/pure/keywords/researchprograms/AFL001000/EMCNIHES045501; name=EMC NIHES-04-55-01; /dk/atira/pure/keywords/researchprograms/AFL001000/EMCONWAR015802; name=EMC ONWAR-01-58-02
Description: Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (vertical bar(p) over cap vertical bar approximate to 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
Document Type: article in journal/newspaper
Language: English
ISSN: 1061-4036; 1546-1718
Relation: info:eu-repo/semantics/altIdentifier/pmid/27089181; info:eu-repo/semantics/altIdentifier/pissn/1061-4036; info:eu-repo/semantics/altIdentifier/eissn/1546-1718
DOI: 10.1038/ng.3552
Availability: https://pure.eur.nl/en/publications/b2323d9c-8034-401c-90f4-4529aab359a8; https://doi.org/10.1038/ng.3552; https://hdl.handle.net/1765/96418
Rights: info:eu-repo/semantics/closedAccess
Accession Number: edsbas.51D0C8F5
Database: BASE