| Title: |
Protection from environmental enteric dysfunction and growth improvement in malnourished newborns by amplification of secretory IgA |
| Authors: |
Perruzza L.; Rezzonico Jost T.; Raneri M.; Gargari G.; Palatella M.; De Ponte Conti B.; Seehusen F.; Heckmann J.; Viemann D.; Guglielmetti S.; Grassi F. |
| Contributors: |
Perruzza, L; Rezzonico Jost, T; Raneri, M; Gargari, G; Palatella, M; De Ponte Conti, B; Seehusen, F; Heckmann, J; Viemann, D; Guglielmetti, S; Grassi, F |
| Publisher Information: |
Cell Press; US |
| Publication Year: |
2024 |
| Collection: |
Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: |
breast milk; environmental enteric dysfunction; live biotherapeutic; malnutrition; microbiota; mucosal immunity; purinergic signaling; secretory immunoglobulin; T follicular helper cell |
| Description: |
Environmental enteric dysfunction (EED) is a condition associated with malnutrition that can progress to malabsorption and villous atrophy. Severe EED results in linear growth stunting, slowed neurocognitive development, and unresponsiveness to oral vaccines. Prenatal exposure to malnutrition and breast feeding by malnourished mothers replicates EED. Pups are characterized by deprivation of secretory IgA (SIgA) and altered development of the gut immune system and microbiota. Extracellular ATP (eATP) released by microbiota limits T follicular helper (Tfh) cell activity and SIgA generation in Peyer's patches (PPs). Administration of a live biotherapeutic releasing the ATP-degrading enzyme apyrase to malnourished pups restores SIgA levels and ameliorates stunted growth. SIgA is instrumental in improving the growth and intestinal immune competence of mice while they are continuously fed a malnourished diet. The analysis of microbiota composition suggests that amplification of endogenous SIgA may exert a dominant function in correcting malnourishment dysbiosis and its consequences on host organisms, irrespective of the actual microbial ecology. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38959887; info:eu-repo/semantics/altIdentifier/wos/WOS:001273584600001; volume:5; issue:7; journal:CELL REPORTS MEDICINE; https://hdl.handle.net/10281/509520 |
| DOI: |
10.1016/j.xcrm.2024.101639 |
| Availability: |
https://hdl.handle.net/10281/509520; https://doi.org/10.1016/j.xcrm.2024.101639 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative Commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.51E2ECAF |
| Database: |
BASE |