| Title: |
Adipocytokine plasma concentrations reflect influence of inflammation but not body mass index (BMI) on clinical outcomes of COVID-19 patients:A prospective observational study from the Netherlands |
| Authors: |
de Nooijer, AH; Kooistra, EJ; Grondman, I; Janssen, NAF; Joosten, LAB; van de Veerdonk, FL; Kox, M; Pickkers, P; Netea, MG |
| Source: |
RCI-COVID-19 Study Grp, de Nooijer, AH, Kooistra, EJ, Grondman, I, Janssen, NAF, Joosten, LAB, van de Veerdonk, FL, Kox, M, Pickkers, P & Netea, MG 2023, 'Adipocytokine plasma concentrations reflect influence of inflammation but not body mass index (BMI) on clinical outcomes of COVID-19 patients : A prospective observational study from the Netherlands', Clinical obesity, vol. 13, no. 2, e12568. https://doi.org/10.1111/cob.12568 |
| Publication Year: |
2023 |
| Subject Terms: |
/dk/atira/pure/keywords/researchprograms/AFL000400/EURESSB19; name=ESSB PSY; /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being |
| Description: |
Obesity is recognized as a risk factor for adverse outcome in COVID-19, but the molecular mechanisms underlying this relationship remain unknown. Adipose tissue functions as an endocrine organ by secreting multiple pro-inflammatory and anti-inflammatory factors, known as adipocytokines, which could be involved in COVID-19 severity. We explored the role of adipocytokines in COVID-19 and its association with BMI, clinical outcome, and inflammation. This is an observational study in 195 hospitalized COVID-19 patients. Serial plasma concentrations of the adipocytokines leptin, adiponectin, resistin, and various inflammatory cytokines were assessed. Adipocytokines were compared between patients with normal weight (BMI: 18.5–24.9 kg/m2), overweight (BMI: 25.0–29.9 kg/m2), and obesity (BMI ≥ 30 kg/m2), between patients admitted to the ICU and to non-ICU clinical wards, and between survivors and non-survivors. Patients with overweight and obesity displayed higher leptin concentrations and lower adiponectin concentrations throughout hospital admission (p < .001), whereas resistin concentrations were not different from patients with normal weight (p = .12). Resistin concentrations correlated with inflammatory markers and were persistently higher in ICU patients and non-survivors compared to non-ICU patients and survivors, respectively (both p < .001), whereas no such relationships were found for the other adipocytokines. In conclusion, leptin and adiponectin are associated with BMI, but not with clinical outcomes and inflammation in COVID-19 patients. In contrast, resistin is not associated with BMI, but high concentrations are associated with worse clinical outcomes and more pronounced inflammation. Therefore, it is unlikely that BMI-related adipocytokines or differences in the inflammatory response underlie obesity as a risk factor for severe COVID-19. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1758-8103; 1758-8111 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36426776; info:eu-repo/semantics/altIdentifier/wos/000890755900001; info:eu-repo/semantics/altIdentifier/pissn/1758-8103; info:eu-repo/semantics/altIdentifier/eissn/1758-8111 |
| DOI: |
10.1111/cob.12568 |
| Availability: |
https://pure.eur.nl/en/publications/10de6114-752a-45e3-903a-9b073aa7d305; https://doi.org/10.1111/cob.12568; https://pure.eur.nl/ws/files/98849453/Clinical_Obesity_-_2022_-_Nooijer.pdf; https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=eur_pure&SrcAuth=WosAPI&KeyUT=WOS:000890755900001&DestLinkType=FullRecord&DestApp=WOS; https://www.scopus.com/pages/publications/85146820960 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.52351D44 |
| Database: |
BASE |