| Title: |
Abstracts from the 2011 BNOS Conference, June 29 - July 1, 2011, Homerton College, Cambridge |
| Authors: |
Ammoun, S; Zhou, L; Barczyk, M; Hilton, D; Hafizi, S; Hanemann, CO; Lehnus, Kristina S; Donovan, Laura K; Pilkington, Geoffrey J; An, Qian; Anderson, Ian A; Thomson, Simon; Bailey, M; Lekka, E; Law, J; Davis, C; Banfill, KE; Loughrey, C; Hatfield, P; Bax, Dorine; Elliott, Richard; Bishop, Ryan; Taylor, Katy; Marshall, Lynley; Gaspar, Nathalie; Viana-Pereira, Marta; Reis, Rui; Renshaw, Jane; Ashworth, Alan; Lord, Chris; Jones, Chris; Bellamy, CA; Shaw, L; Alder, JE; Shorrocks, AJ; Lea, RW; Birks, Suzanne; Burnet, Michael; Pilkington, Geoffrey; Bruch, Julius D; Ho, Jasmine; Watts, Colin; Price, Stephen J; Camp, SJ; Apostolopoulos, V; Mehta, A; Roncaroli, F; Nandi, D; Clark, B; Mackinnon, M; MacLeod, N; Stewart, W; Chalmers, A; Cole, AJ; Hanna, GG; Bailie, K; Conkey, DS; Harney, JA; Darlow, CA; Chapman, S; Mohsen, LA; Price, SJ; Donovan, Laura; Dyer, Helen; Lord, Hannah; Fletcher, Kimberley; das Nair, Roshan; MacNiven, Jamie; Basu, Surajit; Byrne, Paul; Glancz, LJ; Critchley, G; Grech-Sollars, M; Saunders, D; Phipps, K; Clayden, JD; Clark, CA; Greco, Azzura; Acquati, Serena; Marino, Silvia; Hammouche, Salah; Wilkins, Simone P; Smith, Trevor; Brodbelt, Andrew; Clark, Simon; Wong, Alex Hie Lin; Eldridge, Paul; Farah, Jibril Osman; Ho, J; Bruch, J; Watts, C; Lamb, G; Smith, S; James, A; Glegg, M; Jeffcote, T; Boulos, S; Robbins, P; Knuckey, N; Banigo, Adonye; Brodbelt, Andrew R; Jenkinson, Michael D; Jeyapalan, Jennie N; Mumin, Muhammad A; Forshew, Tim; Lawson, Andrew RJ; Tatevossian, Ruth G; Jacques, Thomas S; Sheer, Denise; Kilday, JP; Wright, K; Leavy, S; Lowe, J; Schwalbe, EC; Clifford, SC; Gilbertson, R; Coyle, B; Grundy, RG; Kinsella, Paula; Clynes, Martin; Amberger-Murphy, Verena; Barron, Niall; Lambert, S.R.; Jones, DTW; Pearson, D; Ichimura, I; Collins, VP; Steele, LP; Sinha, P; Chumas, P; Tyler, J; Ogawa, D; Chiocca, EA; DeLay, M; Bronisz, A; Nowicki, M; Godlewski, J; Lawler, SE; Lee, Maggie K; Javadpour, Mohsen; Abel, P; Dawson, T; Lea, B; Lim, Christina Sae-Kyung; Grundy, Paul L; Pendleton, M; Lord, HK; Mackinnon, Mairi; Williamson, Aoife; James, Allan; Stewart, Willie; Clark, Brian; Chalmers, Anthony; Merve, A; Zhang, X; Marino, S; Miller, Suzanne; Rogers, Hazel A; Lyon, Paul; Rand, Vikki; Adamowicz-Brice, Martyna; Clifford, Steven C; Hayden, James T; Dyer, Sara; Pfister, Stefan; Korshunov, Andrey; Brundler, Marie-Anne; Lowe, James; Coyle, Beth; Grundy, Richard G; Nankivell, Matthew; Mulvenna, Paula; Barton, Rachael; Wilson, Paula; Faivre-Finn, Corinne; Pugh, Cheryl; Langley, Ruth; Ngoga, D; Tennant, D; Williams, A; Moss, P; Cruickshank, G; Owusu-Agyemang, K; Bell, S; St.George, J; Piccirillo, Sara GM; Qadri, SRM; Pirola, E; Jenkinson, MD; Brodbelt, A; Rahman, R; Rahman, C; MacArthur, D; Rose, F; Shakesheff, K; Carroll, Cliodhna; Watson, Peter; Hawkins, Mike; Spoudeas, Helen; Walker, David; Holland, Tony; Ring, Howard; Rooney, AG; McNamara, S; Fraser, M; Rampling, R; Carson, A; Grant, R; Royds, JA; Al Nadaf, S; Ahn, A; Chen, Y-J; Wiles, A; Jellinek, D; Braithwaite, AW; Baguley, BC; MacFarlane, MR; Hung, NA; Slatter, TL; Rusbridge, SL; Walmsley, NC; Griffiths, SB; Wilford, PA; Rees, JH; Ryan, D; Liu, P; Galavotti, Sara; Shaked-Rabi, Maya; Tulchinsky, Eugene; Brandner, Sebastian; Salomoni, Paolo; Schulte, Alexander; Günther, Hauke S; Zapf, Svenja; Riethdorf, Sabine; Westphal, Manfred; Lamszus, Katrin; Selvanathan, Senthil K; Salminen, Heidi J; Setua, Sonali; Welland, Mark E; Shevtsov, MA; Khachatryan, WA; Kim, AV; Samochernych, KA; Pozdnyakov, AV; Guzhova, I.V.; Romanova, I.V.; Margulis, BA; Smith, SJ; Barrow, JH; Macarthur, DC; Long, A; Maherally, Zaynah; Smith, James R; Dickson, Luke; Prabhu, Saurabh; Harris, Frederick; Lea, Robert; Snape, Timothy J; Sussman, Maya; Wilne, Sophie; Whitehouse, William; Chow, Gabby; Liu, Jo-Fen; Snape, TJ; Karakoula, A; Rowther, F; Warr, TJ; Zisakis, AK; Varsos, V; Panteli, A; Karypidou, O; Zampethanis, AM; Fotovati, Abbas; Abu-Ali, Samah; Wang, Pei-Shan; Deleyrolle, Loic; Lee, Cathy; Triscott, Joanna; Chen, James Y; Franciosi, Sonia; Nakamura, Yasuhiro; Sugita, Yasuo; Uchiumi, Takeshi; Kuwano, Michihiko; Leavitt, Blair R; Singh, Sheila K; Jury, Alexa; Wakimoto, Hiroaki; Reynolds, Brent A; Pallen, Catherine J; Dunn, Sandra E; Shepherd, SC; Scott, SE; Bowyer, D; Wallace, LM; Hacking, B; Jena, R; Gillard, JH; Lee, C; Fotovati, A; Verraeult, M; Wakimoto, H; Reynolds, B; Dunham, C; Bally, M; Hukin, J; Singhal, S; Singh, S; Dunn, SE |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2011 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Abstracts |
| Description: |
INTRODUCTION: Tumour suppressor merlin deficiency leads to the development of schwannomas, meningiomas and ependymomas. Using our in vitro model of human schwannoma we have demonstrated that merlin-deficiency leads to increased cell proliferation, cell-matrix adhesion and survival involving ErbB2/3, platelet-derived-growth-factor-receptor-β (PDGFR-β), and Insulin-like growth factor receptor-I (IGF-IR) acting via extracellular-signal-regulated-kinase 1/2 (ERK1/2), AKT and JNK. We have inhibited increased proliferation of schwannoma by AZD6244, sorafenib 2, nilotinib, lapatinib 1 and BEZ-235. Since, schwannoma overexpress multiple receptors/signalling pathways the inhibition of a single target is not sufficient. Therefore, all relevant receptors/signalling pathways must be revealed. AXL subfamily RTKs (AXL, SKY, MER and Ron) are over-expressed in cancers correlating with poor prognosis. Expression profiling and phosphoprotein arrays showed that Axl-family receptors are overexpressed/activated in human schwannoma. METHODS: Western blotting, immunohistochemistry, primary human cell culture, proliferation/adhesion assays. RESULTS: AXL, SKY and their ligand Gas-6 are over-expressed as well as activated in human schwannoma cells and tissues leading to increased proliferation and adhesion. CONCLUSIONS: Axl, SKY and Gas-6 constitute new potential therapeutic targets in merlin- deficient tumours. |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://neuro-oncology.oxfordjournals.org/cgi/content/short/13/suppl_2/ii1; http://dx.doi.org/10.1093/neuonc/nor144 |
| DOI: |
10.1093/neuonc/nor144 |
| Availability: |
http://neuro-oncology.oxfordjournals.org/cgi/content/short/13/suppl_2/ii1; https://doi.org/10.1093/neuonc/nor144 |
| Rights: |
Copyright (C) 2011, Society for Neuro-Oncology (SNO) |
| Accession Number: |
edsbas.523A4A7A |
| Database: |
BASE |