| Title: |
Similar 5-year HCC occurrence in Tenofovir- and Entecavir-treated HBV chronic infection in the French AFEF/ANRS CO22 Hepather cohort. |
| Authors: |
Pol, Stanislas; Bonnet, Delphine; Payssan-Sicart, Virginie; Pomes, Chloe; Bailly, François; Beaudoin, Marjolaine; Giboz, Dominique; Hartig-Lavie, Kerstin; Maynard, Marianne; Billaud, Eric; Boutoille, David; Cavellec, Morane; Chevalier, Caroline; Hubert, Isabelle; Goepfert, Pierre; Lannes, Adrien; Lunel, François; Boursier, Jérôme; Boyer, Nathalie; Giuily, Nathalie; Castelnau, Corinne; Scoazec, Giovanna; Chibah, Aziza; Keser, Sylvie; Bonardi, Karim; Vallet-Pichard, Anaïs; Sogni, Philippe; Foucher, Juliette; Hiriart, Jean-Baptiste; Legendre, Amandine; Chermak, Faiza; Irlès-Depé, Marie; Ahmed, Si Nafa Si; Ansaldi, Christelle; Amara, Nisserine Ben; Oules, Valérie; Dunette, Jacqueline; Anty, Rodolphe; Gelsi, Eve; Truchi, Régin; Luckina, Elena; Messaoudi, Nadia; Moussali, Joseph; Dieuleveult, Barbara De; Goin, Héloïse; Labarrière, Damien; Potier, Pascal; Grando-Lemaire, Véronique; Nahon, Pierre; Brulé, Séverin; Monard, Rym; Jezequel, Caroline; Brener, Audrey; Laligant, Anne; Rabot, Aline; Renard, Isabelle; Baumert, Thomas F; Dofföel, Michel; Mutter, Catherine; Simo-Noumbissie, Pauline; Razi, Esma; Barraud, Hélène; Bensenane, Mouni; Nani, Abdelbasset; Hassani-Nani, Sarah; Bernard, Marie-Albertine; Pageaux, Georges-Philippe; Bismuth, Michael; Caillo, Ludovic; Faure, Stéphani; Ripault, Marie Pierre; Bureau, Christophe; Launay, Sarah; Peron, Jean Marie; Robic, Marie Angèl; Tarallo, Lé; Faure, Marine; Froissart, Bruno; Hilleret, Marie-Noelle; Zarski, Jean-Pierre; Goria, Odile; Grard, Victorien; E Montialoux, Hélè; François, Muriel; Ouedraogo, Christian; Pauleau, Christelle; Varault, Anne; Andreani, Tony; E Angoulevant, Bénédic; Chevance, Azeline; Serfaty, Lawrence; Antonini, Teresa; Coilly, Audrey; Vallée, Jean-Charles Duclos; Tateo, Mariagrazia; Bonny, Corinne; Brigitte, Chanteranne; Lamblin, Géraldin; Muti, Léo; Babouri, Abdenour; Filipe, Virginie; Barrault, Camille; Costes, Laurent; Merbah, Soraya; Carrier, Paul; Debette-Gratien, Maryline; Jacques, Jérémie; Lassailly, Guillaume; Artu, Florent; Canva, Valérie; Dharancy, Sébastie; Louvet, Alexandre; Latournerie, Marianne; Bardou, Marc; Mouillot, Thomas; Bacq, Yannick; Barbereau, Didier; Nicolas, Charlotte; Archambeaud, Isabelle; Habes, Sarah; Botta-Fridlund, Danièl; Saillard, Eric; Lafrance, Marie-José; Nzinga, Clovis Luzivika; Dorival, Céline; Zoulim, Fabien; Cagnot, Carole; Decaens, Thomas; Thabut, Dominique; Asselah, Tarik; Mathurin, Philippe; Ganne, Nathalie; Samuel, Didier; Habersetzer, Françoi; Bronowicki, Jean-Pierre; Guyader, Dominique; Rosa, Isabelle; Leroy, Vincent; Chazouilleres, Olivier; Ledinghen, Victor De; Bourliere, Marc; Causse, Xavier; Cales, Paul; Metivier, Sophie; Loustaud-Ratti, Véroniqu; Abergel, Armand; Fontaine, Hélène; Carrat, Fabrice |
| Contributors: |
Département d'hépatologie CHU Cochin; Hôpital Cochin AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM); Physiopathologie du système immunitaire (Inserm U1223); Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM); Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); ANR-19-COHO-0002,Hepather (COHORTES),Therapeutic options for hepatitis B and/or C: a French nationwide cohort study(2019) |
| Source: |
ISSN: 0953-0673. |
| Publisher Information: |
CCSD |
| Publication Year: |
2021 |
| Subject Terms: |
MESH: Antiviral Agents; MESH: Carcinoma; Hepatocellular; MESH: Guanine; MESH: Hepatitis B virus; MESH: Hepatitis B; Chronic; MESH: Humans; MESH: Liver Neoplasms; MESH: Prospective Studies; MESH: Tenofovir; MESH: Treatment Outcome; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Description: |
International audience ; Background: Chronic hepatitis B virus (HBV) infection results in a high risk of cirrhosis and its complications, cirrhosis decompensation (DC), hepatocellular carcinoma (HCC), liver transplantation (LT), death or any of these outcomes (composite endpoint [CE]). Nucleos(t)ide analogues (NUCs) such as tenofovir or entecavir are associated with a reduction in these complications.Aim: To compare the impact of tenofovir and entecavir on these outcomes in patients treated for HBV infection and included in the prospective Hepather cohort.Methods: All patients with HBV infection who had received tenofovir or entecavir for more than 6 months at or after entry in the ANRS CO22 cohort were selected. Patients with HDV and HCV co-infection or prior liver event were excluded. Incidence rates of events were compared using inverse probability of treatment weighting (IPW).Results: The cohort included 1800 patients (986 tenofovir and 814 entecavir). Median follow-up was 4.2 years. The incidences of HCC, DC, LT, ACD, LRD and CE were not different between tenofovir- (1.8 (0.9; 3.2), 0.6 (0.2; 1.6), 0.2 (0.0; 0.8), 1.7 (0.8; 3.0), 0.8 (0.2, 1.8) and 4.1 (3.0; 5.4) per 1000 person-years) and entecavir-treated patients (1.6 (0.7; 3.0), 0.7 (0.2; 1.8), 0.2 (0.0; 1.0), 3.0 (1.7, 4.8), 0.5 (0.1; 1.5) and 5.0 (3.3; 7.2)) per 1000 person-years, respectively.Conclusion: The risk of liver-related events or death was not different between tenofovir- and entecavir-treated patients in this large prospective cohort of predominantly non-cirrhotic French patients.Trial registration number: NCT019553458. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33464621; PUBMED: 33464621 |
| DOI: |
10.1111/apt.16197 |
| Availability: |
https://hal.sorbonne-universite.fr/hal-03784807; https://hal.sorbonne-universite.fr/hal-03784807v1/document; https://hal.sorbonne-universite.fr/hal-03784807v1/file/Pol%20et%20Group%20-%202021%20-%20Similar%205-year%20HCC%20occurrence%20in%20Tenofovir-%20and%20En.pdf; https://doi.org/10.1111/apt.16197 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.5257C07A |
| Database: |
BASE |