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Biological interpretation of genome-wide association studies using predicted gene functions

Title:	Biological interpretation of genome-wide association studies using predicted gene functions
Authors:	Pers TH; Karjalainen JM; Chan Y; Westra HJ; Wood AR; Yang J; Lui JC; Vedantam S; Gustafsson S; Esko T; Frayling T; Speliotes EK; Boehnke M; Raychaudhuri S; Fehrmann RS; Hirschhorn JN; Franke L; Chu AY; Estrada K; Luan J; Kutalik Z; Amin N; Buchkovich ML; Croteau Chonka DC; Day FR; Duan Y; Fall T; Fehrmann R; Ferreira T; Jackson AU; Karjalainen J; Lo KS; Locke AE; Mägi R; Mihailov E; Porcu E; Randall JC; Scherag A; Vinkhuyzen AA; Winkler TW; Workalemahu T; Zhao JH; Absher D; Albrecht E; Anderson D; Baron J; Beekman M; Demirkan A; Ehret GB; Feenstra B; Feitosa MF; Fischer K; Fraser RM; Goel A; Gong J; Justice E; Kanoni S; Kleber ME; Kristiansson K; Lim U; Lotay V; Mangino M; Mateo Leach I; Medina Gomez C; Nalls MA; Nyholt DR; Palmer CD; Pasko D; Pechlivanis S; Prokopenko I; Ried JS; Ripke S; Shungin D; Stancáková A; Strawbridge RJ; Sung YJ; Tanaka T; Teumer A; Trompet S; van der Laan SW; van Setten J; Van Vliet Ostaptchouk JV; Wang Z; Yengo L; Zhang W; Afzal U; Ärnlöv J; Arscott GM; Bandinelli S; Barrett A; Bellis C; Bennett AJ; Berne C; Blüher M; Bolton JL; Böttcher Y; Boyd HA; Bruinenberg M; Buckley BM; Buyske S; Caspersen IH; Chines PS; Clarke R; Claudi Boehm S; Cooper M; Daw EW; De Jong A; Deelen J; Delgado G; Denny JC; Dhonukshe Rutten R; Dimitriou M; Doney AS; Dörr M; Eklund N; Eury E; Folkersen L; Garcia ME; Geller F; Giedraitis V; Go AS; Grallert H; Grammer TB; Gräßler J; Grönberg H; de Groot LC; Groves CJ; Haessler J; Haller T; Hallmans G; Hannemann A; Hartman CA; Hassinen M; Hayward C; Heard Costa NL; Helmer Q; Hemani G; Henders AK; Hillege HL; Hlatky MA; Hoffmann W; Hoffmann P; Holmen O; Houwing Duistermaat JJ; Illig T; Isaacs A; James AL; Jeff J; Johansen B; Johansson Å; Jolley J; Juliusdottir T; Junttila J; Kho AN; Kinnunen L; Klopp N; Kocher T; Kratzer W; Lichtner P; Lind L; Lindström J; Lobbens S; Lorentzon M; Lu Y; Lyssenko V; Magnusson PK; Mahajan A; Maillard M; McArdle WL; McKenzie CA; McLachlan S; McLaren PJ; Menni C; Merger S; Milani L; Moayyeri A; Monda KL; Morken MA; Müller G; Müller Nurasyid M; Musk AW; Narisu N; Nauck M; Nolte IM; Nöthen MM; Oozageer L; Pilz S; Rayner NW; Renstrom F; Robertson NR; Rose LM; Roussel R; Sanna S; Scharnagl H; Scholtens S; Schumacher FR; Schunkert H; Scott RA; Sehmi J; Seufferlein T; Shi J; Silventoinen K; Smit JH; Smith AV; Smolonska J; Stanton AV; Stirrups K; Stott DJ; Stringham HM; Sundström J; Swertz MA; Syvänen AC; Tayo BO; Thorleifsson G; Tyrer JP; van Dijk S; van Schoor NM; van der Velde N; van Heemst D; van Oort FV; Vermeulen SH; Verweij N; Vonk JM; Waite LL; Waldenberger M; Wennauer R; Wilkens LR; Willenborg C; Wilsgaard T; Wojczynski MK; Wong A; Wright AF; Zhang Q; Arveiler D; Bakker SJ; Beilby J; Bergman RN; Bergmann S; Biffar R; Blangero J; Boomsma I; Bornstein SR; Bovet P; BRAMBILLA, PAOLO; Brown MJ; Campbell H; Caulfield MJ; Chakravarti A; Collins R; Collins FS; Crawford DC; Cupples LA; Danesh J; de Faire U; den Ruijter HM; Erbel R; Erdmann J; Eriksson JG; Farrall M; Ferrannini E; Ferrières J; Ford I; Forouhi NG; Forrester T; Gansevoort RT; Gejman PV; Gieger C; Golay A; Gottesman O; Gudnason V; Gyllensten U; Haas DW; Hall AS; Harris TB; Hattersley AT; Heath AC; Hengstenberg C; Hicks AA; Hindorff LA; Hingorani AD; Hofman A; Hovingh GK; Humphries SE; Hunt SC; Hypponen E; Jacobs KB; Jarvelin MR; Jousilahti P; Jula AM; Kaprio J; Kastelein JJ; Kayser M; Kee F; Keinanen Kiukaanniemi SM; Kiemeney LA; Kooner JS; Kooperberg C; Koskinen S; Kovacs P; Kraja AT; Kumari M; Kuusisto J; Lakka TA; Langenberg C; Le Marchand L; Lehtimäki T; Lupoli S; Madden PA; Männistö S; Manunta P; Marette A; Matise TC; McKnight B; Meitinger T; Moll FL; Montgomery GW; Morris AD; Morris AP; Murray JC; Nelis M; Ohlsson C; Oldehinkel AJ; Ong KK; Ouwehand WH; Pasterkamp G; Peters A; Pramstaller PP; Price JF; Qi L; Raitakari OT; Rankinen T; Rao DC; Rice TK; Ritchie M; Rudan I; Salomaa V; Samani NJ; Saramies J; Sarzynski MA; Schwarz PE; Sebert S; Sever P; Shuldiner AR; Sinisalo J; Steinthorsdottir V; Stolk RP; Tardif JC; Tönjes A; Tremblay A; Tremoli E; Virtamo J; Vohl MC; Amouyel P; Asselbergs FW; Assimes TL; Bochud M; Boehm BO; Boerwinkle E; Bottinger EP; Bouchard C; Cauchi S; Chambers JC; Chanock SJ; Cooper RS; de Bakker PI; Dedoussis G; Ferrucci L; Franks PW; Froguel P; Groop LC; Haiman CA; Hamsten A; Hayes MG; Hui J; Hunter DJ; Hveem K; Jukema JW; Kaplan RC; Kivimaki M; Kuh D; Laakso M; Liu Y; Martin NG; März W; Melbye M; Moebus S; Munroe PB; Njølstad I; Oostra BA; Palmer CN; Pedersen NL; Perola M; Pérusse L; Peters U; Powell JE; Power C; Quertermous T; Rauramaa R; Reinmaa E; Ridker PM; Rivadeneira F; Rotter JI; Saaristo TE; Saleheen D; Schlessinger D; Slagboom PE; Snieder H; Spector TD; Strauch K; Stumvoll M; Tuomilehto J; Uusitupa M; van der Harst P; Völzke H; Walker M; Wareham NJ; Watkins H; Wichmann HE; Wilson JF; Zanen P; Deloukas P; Heid IM; Lindgren CM; Mohlke KL; Thorsteinsdottir U; Barroso I; Fox CS; North KE; Strachan DP; Beckmann JS; Berndt SI; Borecki IB; McCarthy MI; Metspalu A; Stefansson K; Uitterlinden AG; van Duijn CM; Willer CJ; Price AL; Lettre G; Loos RJ; Weedon MN; Ingelsson E; O'Connell JR; Abecasis GR; Chasman DI; Goddard ME; Visscher PM; Frayling T.M.
Contributors:	Pers, T; Karjalainen, J; Chan, Y; Westra, H; Wood, A; Yang, J; Lui, J; Vedantam, S; Gustafsson, S; Esko, T; Frayling, T; Speliotes, E; Boehnke, M; Raychaudhuri, S; Fehrmann, R; Hirschhorn, J; Franke, L; Chu, A; Estrada, K; Luan, J; Kutalik, Z; Amin, N; Buchkovich, M; Croteau Chonka, D; Day, F; Duan, Y; Fall, T; Ferreira, T; Jackson, A; Lo, K; Locke, A; Mägi, R; Mihailov, E; Porcu, E; Randall, J; Scherag, A; Vinkhuyzen, A; Winkler, T; Workalemahu, T; Zhao, J; Absher, D; Albrecht, E; Anderson, D; Baron, J; Beekman, M; Demirkan, A; Ehret, G; Feenstra, B; Feitosa, M; Fischer, K; Fraser, R; Goel, A; Gong, J; Justice, E; Kanoni, S; Kleber, M; Kristiansson, K; Lim, U; Lotay, V; Mangino, M; Mateo Leach, I; Medina Gomez, C; Nalls, M; Nyholt, D; Palmer, C; Pasko, D; Pechlivanis, S; Prokopenko, I; Ried, J; Ripke, S; Shungin, D; Stancáková, A; Strawbridge, R; Sung, Y; Tanaka, T; Teumer, A; Trompet, S; van der Laan, S; van Setten, J; Van Vliet Ostaptchouk, J; Wang, Z; Yengo, L; Zhang, W; Afzal, U; Ärnlöv, J; Arscott, G; Bandinelli, S; Barrett, A; Bellis, C; Bennett, A
Publisher Information:	Nature Research; GB
Publication Year:	2015
Collection:	Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive)
Subject Terms:	Biochemistry; Genetics and Molecular Biology (all); Settore BIOS-09/A - Biochimica clinica e biologia molecolare clinica
Description:	The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.
Document Type:	article in journal/newspaper
File Description:	STAMPA
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/25597830; info:eu-repo/semantics/altIdentifier/wos/WOS:000348741300001; volume:6; journal:NATURE COMMUNICATIONS; https://hdl.handle.net/10281/79443; http://www.nature.com/ncomms/index.html
DOI:	10.1038/ncomms6890
Availability:	https://hdl.handle.net/10281/79443; https://doi.org/10.1038/ncomms6890; http://www.nature.com/ncomms/index.html
Rights:	info:eu-repo/semantics/openAccess
Accession Number:	edsbas.528A6B49
Database:	BASE